Review by Nihar Desai – 11/03/2020 – 12:35pm

Data Request Number: 2020-4417 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Yes, or it’s highly likely Please use this space to provide any comments, feedback or concerns (optional):

Very interesting analysis, I am not sure I am well positioned to comment on the methods. That said, there is now a very large body of evidence of support SGLT2 inhibitors for patients with type 2 DM and cardiovascular disease or congestive heart failure (regardless of diabetes status).

Recommendation for this data request: Approve