Samnani S, Wong ECL, Hamam H, Dulai PS, Marshall JK, Jairath V, Reinisch W, Narula N. Outcomes of patients with prior biologic intolerance are better than those with biologic failure in clinical trials of inflammatory bowel disease. J Crohns Colitis. 2024 Sep 20:jjae151. doi: 10.1093/ecco-jcc/jjae151. Epub ahead of print. PMID: 39302135.
Featured Articles
No Impact of Concomitant Medications on Efficacy and Safety of Biologics and Small Molecules for Ulcerative Colitis
Ahuja D, Zou G, Solitano V, Syal G, Lee HH, Ma C, Jairath V, Singh S. No Impact of Concomitant Medications on Efficacy and Safety of Biologics and Small Molecules for Ulcerative Colitis. Clin Gastroenterol Hepatol. 2024 Oct 10:S1542-3565(24)00877-2. doi: 10.1016/j.cgh.2024.08.040. Epub ahead of print. PMID: 39395572.
Examining the Effect of Missing Data and Unmeasured Confounding on External Comparator Studies: Case Studies and Simulations
Rippin G, Sanz H, Hoogendoorn WE, Ballarini NM, Largent JA, Demas E, Postmus D, Framke T, Dávila LMA, Quinten C, Pignatti F. Examining the Effect of Missing Data and Unmeasured Confounding on External Comparator Studies: Case Studies and Simulations. Drug Saf. 2024 Aug 5. doi: 10.1007/s40264-024-01467-9. Epub ahead of print. PMID: 39102176.
Pooling Alzheimer’s disease clinical trial data to develop personalized medicine approaches is easier said than done: A proof-of-principle study and call to action
Dubbelman MA, Vromen EM, Tijms BM, Berkhof J, Ottenhoff L, Vijverberg EGB, Prins ND, van der Flier WM, Sikkes SAM. Pooling Alzheimer’s disease clinical trial data to develop personalized medicine approaches is easier said than done: A proof-of-principle study and call to action. Alzheimers Dement (N Y). 2024 Aug 7;10(3):e12485. doi: 10.1002/trc2.12485. PMID: 39114370; PMCID: PMC11303826.
Demonstration of Group-Level and Individual-Level Efficacy Using Time-to-Event Designs for Clinical Trials of Antiseizure Medications
Kerr WT, Kok N, Reddy AS, McFarlane KN, Stern JM, Pennell PB, Stacey W, French J. Demonstration of Group-Level and Individual-Level Efficacy Using Time-to-Event Designs for Clinical Trials of Antiseizure Medications. Neurology. 2024 Aug 27;103(4):e209713. doi: 10.1212/WNL.0000000000209713. Epub 2024 Jul 25. PMID: 39052963; PMCID: PMC11271390.
Assessing trial representativeness using serious adverse events: an observational analysis using aggregate and individual-level data from clinical trials and routine healthcare data
Hanlon P, Butterly E, Shah ASV, Hannigan LJ, Wild SH, Guthrie B, Mair FS, Dias S, Welton NJ, McAllister DA. Assessing trial representativeness using serious adverse events: an observational analysis using aggregate and individual-level data from clinical trials and routine healthcare data. BMC Med. 2022 Oct 28;20(1):410. doi: 10.1186/s12916-022-02594-9. PMID: 36303169; PMCID: PMC9615407.
Higher Postinduction Infliximab Concentrations Are Associated With Favorable Clinical Outcomes in Pediatric Crohn’s Disease: A Post Hoc Analysis of the REACH Trial
Cheifetz AS, Vande Casteele N, Wang Z, Dubinsky MC, Papamichael K. Higher Postinduction Infliximab Concentrations Are Associated With Favorable Clinical Outcomes in Pediatric Crohn’s Disease: A Post Hoc Analysis of the REACH Trial. Am J Gastroenterol. 2023 Mar 1;118(3):485-490. doi: 10.14309/ajg.0000000000002096. Epub 2022 Dec 23. PMID: 36624036; PMCID: PMC9991960.
Modeling First-Line Daratumumab Use for Newly Diagnosed, Transplant-Ineligible, Multiple Myeloma: A Cost-Effectiveness and Risk Analysis for Healthcare Payers
Bayani DB, Lin YC, Nagarajan C, Ooi MG, Tso ACY, Cairns J, Wee HL. Modeling First-Line Daratumumab Use for Newly Diagnosed, Transplant-Ineligible, Multiple Myeloma: A Cost-Effectiveness and Risk Analysis for Healthcare Payers. Pharmacoecon Open. 2024 Sep;8(5):651-664. doi: 10.1007/s41669-024-00503-9. Epub 2024 Jun 20. PMID: 38900407; PMCID: PMC11362436.
Differential efficacy of medical therapies for ulcerative colitis according to disease extent: patient-level analysis from multiple randomized controlled trials
Vuyyuru SK, Ma C, Nguyen TM, Zou G, Peyrin-Biroulet L, Danese S, Dulai P, Narula N, Singh S, Jairath V. Differential efficacy of medical therapies for ulcerative colitis according to disease extent: patient-level analysis from multiple randomized controlled trials. EClinicalMedicine. 2024 May 4;72:102621. doi: 10.1016/j.eclinm.2024.102621. PMID: 38726222; PMCID: PMC11079462.
Characterizing Treatment Non-responders vs. Responders in Completed Alzheimer’s Disease Clinical Trials
Wang D, Ling Y, Harris K, Schulz PE, Jiang X, Kim Y. Characterizing Treatment Non-responders vs. Responders in Completed Alzheimer’s Disease Clinical Trials. medRxiv [Preprint]. 2023 Oct 30:2023.10.27.23297685. doi: 10.1101/2023.10.27.23297685. PMID: 37961216; PMCID: PMC10635230.
Personalizing treatment selection in Crohn’s disease: a meta-analysis of individual participant data from fifteen randomized controlled trials
Rudrapatna VA, Ravindranath VG, Arneson DV, Mosenia A, Butte AJ, Wang S. Personalizing treatment selection in Crohn’s disease: a meta-analysis of individual participant data from fifteen randomized controlled trials. medRxiv [Preprint]. 2023 Nov 12:2023.11.10.23291837. doi: 10.1101/2023.11.10.23291837. PMID: 37986977; PMCID: PMC10659518.
Quantifying proportion of treatment effect by surrogate endpoint under heterogeneity
Guo X, Bourgeois FT, Cai T. Quantifying proportion of treatment effect by surrogate endpoint under heterogeneity. Stat Methods Med Res. 2024 Jul;33(7):1152-1162. doi: 10.1177/09622802241247719. Epub 2024 May 8. PMID: 38717356.
Baseline Patient-reported Symptoms Less Predictive Than MM-SES-CD for Endoscopic Remission in Crohn’s Disease
Narula N, Wong ECL, Aruljothy A, Dulai PS, Colombel JF, Marshall JK, Ferrante M, Reinisch W. Baseline Patient-reported Symptoms Less Predictive Than MM-SES-CD for Endoscopic Remission in Crohn’s Disease. J Clin Gastroenterol. 2023 Oct 1;57(9):913-919. doi: 10.1097/MCG.0000000000001774. PMID: 36227009.
Predictors of Clinical Remission to Placebo in Clinical Trials of Crohn’s Disease
Wong ECL, Dulai PS, Marshall JK, Jairath V, Reinisch W, Narula N. Predictors of Clinical Remission to Placebo in Clinical Trials of Crohn’s Disease. Inflamm Bowel Dis. 2023 Sep 1;29(9):1390-1398. doi: 10.1093/ibd/izac231. PMID: 36426810.
Ulcer Size After Induction Therapy Performs Better Than Symptom Assessment for Prediction of One Year Endoscopic Remission in Crohn’s Disease: A Post Hoc Analysis
Pray C, Wong ECL, Aruljothy A, Dulai PS, Marshall JK, Reinisch W, Narula N. Ulcer Size After Induction Therapy Performs Better Than Symptom Assessment for Prediction of One Year Endoscopic Remission in Crohn’s Disease: A Post Hoc Analysis. Inflamm Bowel Dis. 2023 Aug 1;29(8):1263-1271. doi: 10.1093/ibd/izac210. PMID: 36179118.
Calibrated meta-analysis to estimate the efficacy of mental health treatments in target populations: an application to paliperidone trials for treatment of schizophrenia
Hong H, Liu L, Mojtabai R, Stuart EA. Calibrated meta-analysis to estimate the efficacy of mental health treatments in target populations: an application to paliperidone trials for treatment of schizophrenia. BMC Med Res Methodol. 2023 Jun 26;23(1):150. doi: 10.1186/s12874-023-01958-w. PMID: 37365521; PMCID: PMC10294408.
Development of a treatment selection algorithm for SGLT2 and DPP-4 inhibitor therapies in people with type 2 diabetes: a retrospective cohort study
Dennis JM, Young KG, McGovern AP, Mateen BA, Vollmer SJ, Simpson MD, Henley WE, Holman RR, Sattar N, Pearson ER, Hattersley AT, Jones AG, Shields BM; MASTERMIND consortium. Development of a treatment selection algorithm for SGLT2 and DPP-4 inhibitor therapies in people with type 2 diabetes: a retrospective cohort study. Lancet Digit Health. 2022 Dec;4(12):e873-e883. doi: 10.1016/S2589-7500(22)00174-1. PMID: 36427949.
Heterogeneity of Radiological Progression Patterns and Association with Outcomes in Patients with Metastatic Prostate Cancer
Ni X, Wu J, Pan J, Li X, Fang B, Wei Y, Ye D, Liang F, Zhu Y. Heterogeneity of Radiological Progression Patterns and Association with Outcomes in Patients with Metastatic Prostate Cancer. Eur Urol Oncol. 2024 Aug;7(4):897-905. doi: 10.1016/j.euo.2023.11.019. Epub 2023 Dec 26. PMID: 38151441.
Comorbidity and health-related quality of life in people with a chronic medical condition in randomised clinical trials: An individual participant data meta-analysis
Butterly EW, Hanlon P, Shah ASV, Hannigan LJ, McIntosh E, Lewsey J, Wild SH, Guthrie B, Mair FS, Kent DM, Dias S, Welton NJ, McAllister DA. Comorbidity and health-related quality of life in people with a chronic medical condition in randomised clinical trials: An individual participant data meta-analysis. PLoS Med. 2023 Jan 17;20(1):e1004154. doi: 10.1371/journal.pmed.1004154. PMID: 36649256; PMCID: PMC9844862.
Effect of age, sex, and morbidity count on trial attrition: meta-analysis of individual participant level data from phase 3/4 industry funded clinical trials
Lees JS, Hanlon P, Butterly EW, Wild SH, Mair FS, Taylor RS, Guthrie B, Gillies K, Dias S, Welton NJ, McAllister DA. Effect of age, sex, and morbidity count on trial attrition: meta-analysis of individual participant level data from phase 3/4 industry funded clinical trials. BMJ Med. 2022 Sep 1;1(1):e000217. doi: 10.1136/bmjmed-2022-000217. PMID: 36936559; PMCID: PMC9978693.
Frailty in randomised controlled trials for dementia or mild cognitive impairment measured via the frailty index: prevalence and prediction of serious adverse events and attrition
Wightman H, Quinn TJ, Mair FS, Lewsey J, McAllister DA, Hanlon P. Frailty in randomised controlled trials for dementia or mild cognitive impairment measured via the frailty index: prevalence and prediction of serious adverse events and attrition. Alzheimers Res Ther. 2023 Jun 13;15(1):110. doi: 10.1186/s13195-023-01260-3. PMID: 37312157; PMCID: PMC10262528.
Early Prostate-Specific Antigen Response by 6 Months Is Predictive of Treatment Effect in Metastatic Hormone Sensitive Prostate Cancer: An Exploratory Analysis of TITAN Trial
Roy S, Sun Y, Chi KN, Ong M, Malone S, Wallis CJD, Kishan AU, Malone J, Swami U, Gebrael G, Brown JR, Jia AY, Morgan SC, Saad F, Chowdhury S, Agarwal N, Spratt DE. Early Prostate-Specific Antigen Response by 6 Months Is Predictive of Treatment Effect in Metastatic Hormone Sensitive Prostate Cancer: An Exploratory Analysis of TITAN Trial. J Urol. 2024 Jul 26:101097JU0000000000004158. doi: 10.1097/JU.0000000000004158. Epub ahead of print. PMID: 39058790.
Antithrombotic utilization, adverse events, and associations with treatment outcomes in multiple myeloma: pooled analysis of three clinical trials
Almansour SA, Alqudah MAY, Abuhelwa Z, Al-Shamsi HO, Alhuraiji A, Semreen MH, Bustanji Y, Alzoubi KH, Modi ND, Mckinnon RA, Sorich MJ, Hopkins AM, Abuhelwa AY. Antithrombotic utilization, adverse events, and associations with treatment outcomes in multiple myeloma: pooled analysis of three clinical trials. Ther Adv Med Oncol. 2024 Sep 2;16:17588359241275387. doi: 10.1177/17588359241275387. PMID: 39229471; PMCID: PMC11369879.
Sequential covariate-adjusted randomization via hierarchically minimizing Mahalanobis distance and marginal imbalance
Yang H, Qin Y, Li Y, Hu F. Sequential covariate-adjusted randomization via hierarchically minimizing Mahalanobis distance and marginal imbalance. Biometrics. 2024 Mar 27;80(2):ujae047. doi: 10.1093/biomtc/ujae047. PMID: 38801258.
Balancing covariates in multi-arm trials via adaptive randomization
Yang, Haoyu; Qin, Yichen; Wang, Fan; Li, Yang; Hu, Feifang. Balancing covariates in multi-arm trials via adaptive randomization. Comput.Stat.Data Anal. 2023 March; 179:107642. doi: 10.1016/j.csda.2022.107642.
Bone-Modifying Agents in Patients With High-Risk Metastatic Castration-Sensitive Prostate Cancer Treated With Abiraterone Acetate
Fukuokaya W, Mori K, Urabe F, Igarashi T, Yanagisawa T, Tsuzuki S, Honda M, Miki K, Kimura T. Bone-Modifying Agents in Patients With High-Risk Metastatic Castration-Sensitive Prostate Cancer Treated With Abiraterone Acetate. JAMA Netw Open. 2024 Mar 4;7(3):e242467. doi: 10.1001/jamanetworkopen.2024.2467. PMID: 38488793; PMCID: PMC10943414.
Effect of Concomitant Medications on Treatment Response and Survival in De Novo Metastatic Prostate Cancer: Secondary Analysis of the LATITUDE Study
Roy S, Saad F, Wallis CJD, Sun Y, Spratt DE, Akilla R, Kishan AU, Malone S, Morgan SC. Effect of Concomitant Medications on Treatment Response and Survival in De Novo Metastatic Prostate Cancer: Secondary Analysis of the LATITUDE Study. Eur J Cancer. 2024 Mar;199:113348. doi: 10.1016/j.ejca.2023.113348. Epub 2023 Sep 20. PMID: 38262848.
Relapse in clinically stable adult patients with schizophrenia or schizoaffective disorder: evidence-based criteria derived by equipercentile linking and diagnostic test accuracy meta-analysis
Siafis S, Brandt L, McCutcheon RA, Gutwinski S, Schneider-Thoma J, Bighelli I, Kane JM, Arango C, Kahn RS, Fleischhacker WW, McGorry P, Carpenter WT, Falkai P, Hasan A, Marder SR, Schooler N, Engel RR, Honer WG, Buchanan RW, Davidson M, Weiser M, Priller J, Davis JM, Howes OD, Correll CU, Leucht S. Relapse in clinically stable adult patients with schizophrenia or schizoaffective disorder: evidence-based criteria derived by equipercentile linking and diagnostic test accuracy meta-analysis. Lancet Psychiatry. 2024 Jan;11(1):36-46. doi: 10.1016/S2215-0366(23)00364-4. Epub 2023 Nov 30. PMID: 38043562.
Implications of metastatic stage at presentation in docetaxel naïve metastatic castrate resistant prostate cancer
Roy S, Wallis CJD, Morgan SC, Kishan AU, Le ATT, Malone J, Sun Y, Spratt DE, Saad F, Malone S. Implications of metastatic stage at presentation in docetaxel naïve metastatic castrate resistant prostate cancer. Prostate. 2023 Jul;83(10):912-921. doi: 10.1002/pros.24512. Epub 2023 Apr 18. PMID: 37071764.
Treatment effect modification due to comorbidity: Individual participant data meta-analyses of 120 randomised controlled trials
Hanlon P, Butterly EW, Shah AS, Hannigan LJ, Lewsey J, Mair FS, Kent DM, Guthrie B, Wild SH, Welton NJ, Dias S, McAllister DA. Treatment effect modification due to comorbidity: Individual participant data meta-analyses of 120 randomised controlled trials. PLoS Med. 2023 Jun 6;20(6):e1004176. doi: 10.1371/journal.pmed.1004176. PMID: 37279199; PMCID: PMC10243630.
Development and validation of a multivariable prognostic model in de novo metastatic castrate sensitive prostate cancer
Roy S, Sun Y, Wallis CJD, Morgan SC, Grimes S, Malone J, Kishan AU, Mukherjee D, Spratt DE, Saad F, Malone S. Development and validation of a multivariable prognostic model in de novo metastatic castrate sensitive prostate cancer. Prostate Cancer Prostatic Dis. 2023 Mar;26(1):119-125. doi: 10.1038/s41391-022-00560-3. Epub 2022 Jul 5. PMID: 35790787.
Radiographic Progression Without Corresponding Prostate-specific Antigen Progression in Patients with Metastatic Castration-sensitive Prostate Cancer Receiving Apalutamide: Secondary Analysis of the TITAN Trial
Fukuokaya W, Yanagisawa T, Mori K, Urabe F, Rajwa P, Briganti A, Shariat SF, Kimura T. Radiographic Progression Without Corresponding Prostate-specific Antigen Progression in Patients with Metastatic Castration-sensitive Prostate Cancer Receiving Apalutamide: Secondary Analysis of the TITAN Trial. Eur Urol Oncol. 2024 Apr 29:S2588-9311(24)00101-9. doi: 10.1016/j.euo.2024.04.009. Epub ahead of print. PMID: 38688767.
Adaptive steroid tapering impedes corticosteroid-free remissions compared to forced tapering in clinical trials of ulcerative colitis
Neeraj Narula, Hasan Hamam, Jasmine Liu, Emily C L Wong, John K Marshall, Vipul Jairath, Stephen B Hanauer, Walter Reinisch, Parambir S Dulai, Adaptive steroid tapering impedes corticosteroid-free remissions compared to forced tapering in clinical trials of ulcerative colitis, Journal of Crohn’s and Colitis, 2024;, jjae092, https://doi.org/10.1093/ecco-jcc/jjae092
Platelet-to-lymphocyte percentage ratio for assessing disease activity and predicting therapeutic outcomes in ulcerative colitis
Zheng J, Wang Y, Li L, Chen M, Chen R, Zhang S. Platelet-to-lymphocyte percentage ratio for assessing disease activity and predicting therapeutic outcomes in ulcerative colitis. Int Immunopharmacol. 2024 Jun 23;137:112506. doi: 10.1016/j.intimp.2024.112506. Epub ahead of print. PMID: 38914032.
Effects of newer anti-hyperglycemic agents on cardiovascular outcomes in older adults: Systematic review and meta-analysis
Bilal A, Yi F, Gonzalez GR, Ali M, Im K, Ruff CT, Thethi TK, Pratley RE. Effects of newer anti-hyperglycemic agents on cardiovascular outcomes in older adults: Systematic review and meta-analysis. J Diabetes Complications. 2024 Jun 8;38(8):108783. doi: 10.1016/j.jdiacomp.2024.108783. Epub ahead of print. PMID: 38870731.
Does Slow and Steady Win the Race? Rates of Antipsychotic Discontinuation, Antipsychotic Dose, and Risk of Psychotic Relapse
McCutcheon RA, Taylor D, Rubio J, Nour J, Pillinger T, Murray RM, Jauhar S. Does Slow and Steady Win the Race? Rates of Antipsychotic Discontinuation, Antipsychotic Dose, and Risk of Psychotic Relapse. Schizophr Bull. 2024 Apr 30;50(3):513-520. doi: 10.1093/schbul/sbad139. PMID: 37797288; PMCID: PMC11059789.
The impact of autoantibodies on the efficacy of biological disease-modifying anti-rheumatic drugs in rheumatoid arthritis: meta-analysis of randomized controlled trials
Takase-Minegishi K, Böhringer S, Nam JL, Kaneko Y, Behrens F, Saevarsdottir S, Detert J, Leirisalo-Repo M, van der Heijde D, Landewé R, Ramiro S, van der Woude D. The impact of autoantibodies on the efficacy of biological disease-modifying anti-rheumatic drugs in rheumatoid arthritis: meta-analysis of randomized controlled trials. Rheumatology (Oxford). 2024 Feb 16:keae113. doi: 10.1093/rheumatology/keae113. Epub ahead of print. PMID: 38366945.
Effect of Canagliflozin on Heart Failure Hospitalization in Diabetes According to Baseline Heart Failure Risk
Khan MS, Segar MW, Usman MS, Patel KV, Van Spall HGC, DeVore AD, Vaduganathan M, Lam CSP, Zannad F, Verma S, Butler J, Tang WHW, Pandey A. Effect of Canagliflozin on Heart Failure Hospitalization in Diabetes According to Baseline Heart Failure Risk. JACC Heart Fail. 2023 Jul;11(7):825-835. doi: 10.1016/j.jchf.2023.03.025. Epub 2023 May 24. PMID: 37227388.
Bedaquiline exposure in people with drug-resistant TB treatedfor diabetes: analysis of two phase 2 trials
Bolhuis MS, Akkerman OW, Sturkenboom MGG, van Boven JFM, Alffenaar JC, Stevens J. Bedaquiline exposure in people with drug-resistant TB treated for diabetes: analysis of two phase 2 trials. Int J Tuberc Lung Dis. 2023 Apr 1;27(4):335-337. doi: 10.5588/ijtld.22.0581. PMID: 37035978.
Identifying surrogate markers in real-world comparativeeffectiveness research
Han L, Wang X, Cai T. Identifying surrogate markers in real-world comparative effectiveness research. Stat Med. 2022 Nov 20;41(26):5290-5304. doi: 10.1002/sim.9569. Epub 2022 Sep 5. PMID: 36062392.
Radiographic Progression Without Corresponding Prostate-specific Antigen Progression in Patients with Metastatic Castration-sensitive Prostate Cancer Receiving Apalutamide: Secondary Analysis of the TITAN Trial
Fukuokaya W, Yanagisawa T, Mori K, Urabe F, Rajwa P, Briganti A, Shariat SF, Kimura T. Radiographic Progression Without Corresponding Prostate-specific Antigen Progression in Patients with Metastatic Castration-sensitive Prostate Cancer Receiving Apalutamide: Secondary Analysis of the TITAN Trial. Eur Urol Oncol. 2024 Apr 29:S2588-9311(24)00101-9. doi: 10.1016/j.euo.2024.04.009. Epub ahead of print. PMID: 38688767
Impact of Asian Race on Prognosis in De Novo Metastatic Prostate Cancer
Ni X, Luu M, Ma W, Zhang T, Wei Y, Freedland SJ, Ye D, Daskivich TJ, Zhu Y. Impact of Asian Race on Prognosis in De Novo Metastatic Prostate Cancer. J Natl Compr Canc Netw. 2023 Jul;21(7):733-741.e3. doi: 10.6004/jnccn.2023.7027. PMID: 37433430.
Heterogeneity and Utility of Pharmaceutical Company Sharing of Individual-Participant Data Packages
Hopkins AM, Modi ND, Abuhelwa AY, Kichenadasse G, Kuderer NM, Lyman GH, Wiese MD, McKinnon RA, Rockhold FW, Mann A, Rowland A, Sorich MJ. Heterogeneity and Utility of Pharmaceutical Company Sharing of Individual-Participant Data Packages. JAMA Oncol. 2023 Dec 1;9(12):1621-1626. doi: 10.1001/jamaoncol.2023.3996. PMID: 37796495; PMCID: PMC10557028.
Association of proton pump inhibitor use with survival and adverse effects outcomes in patients with multiple myeloma: pooled analysis of three clinical trials
Almansour SA, Alqudah MAY, Abuhelwa Z, Al-Shamsi HO, Semreen MH, Bustanji Y, Soare NC, McKinnon RA, Sorich MJ, Hopkins AM, Abuhelwa AY. Association of proton pump inhibitor use with survival and adverse effects outcomes in patients with multiple myeloma: pooled analysis of three clinical trials. Sci Rep. 2024 Jan 5;14(1):591. doi: 10.1038/s41598-023-48640-1. PMID: 38182614; PMCID: PMC10770405.
Rapidly achieving clinical remission in ulcerative colitis indicates better endoscopic and histological outcomes
Chen R, Tie Y, Huang Y, Zhang X, Zeng Z, Chen M, Li L, Zhang S. Rapidly achieving clinical remission in ulcerative colitis indicates better endoscopic and histological outcomes. United European Gastroenterol J. 2023 Dec 30. doi: 10.1002/ueg2.12515. Epub ahead of print. PMID: 38159047.
Illusory generalizability of clinical prediction models
Chekroud AM, Hawrilenko M, Loho H, Bondar J, Gueorguieva R, Hasan A, Kambeitz J, Corlett PR, Koutsouleris N, Krumholz HM, Krystal JH, Paulus M. Illusory generalizability of clinical prediction models. Science. 2024 Jan 12;383(6679):164-167. doi: 10.1126/science.adg8538. Epub 2024 Jan 11. PMID: 38207039.
Combining Real-World and Randomized Control Trial Data Using Data-Adaptive Weighting via the On-Trial Score
Harton J, Segal B, Mamtani R, Mitra N, Hubbard RA. Combining real-world and randomized control trial data using data-adaptive weighting via the on-trial score. Statistics in Biopharmaceutical Research. 2022;15(2):408–20. doi:10.1080/19466315.2022.2071982
Association between concomitant proton pump inhibitor use and survival of patients with metastatic prostate cancer receiving abiraterone acetate: a post-hoc analysis of pooled data from three randomized controlled trials
Fukuokaya W, Mori K, Yanagisawa T, Akazawa K, Shimomura T, Kimura T. Association between concomitant proton pump inhibitor use and survival of patients with metastatic prostate cancer receiving abiraterone acetate: a post-hoc analysis of pooled data from three randomized controlled trials. Prostate Cancer Prostatic Dis. 2023 Jul 18. doi: 10.1038/s41391-023-00695-x. Epub ahead of print. PMID: 37464102.
A powerful partnership: researchers and patients working together to develop a patient-facing summary of clinical trial outcome data
Ruzich E, Ritchie J, Ginchereau Sowell F, et al. A powerful partnership: researchers and patients working together to develop a patient-facing summary of clinical trial outcome data. Journal of the American Medical Informatics Association : JAMIA. 2023 Jun:ocad099. DOI: 10.1093/jamia/ocad099. PMID: 37341698.
Linkage of Young Mania Rating Scale to Clinical Global Impression Scale to Enhance Utility in Clinical Practice and Research Trials
Samara MT, Levine SZ, Leucht S. Linkage of Young Mania Rating Scale to Clinical Global Impression Scale to Enhance Utility in Clinical Practice and Research Trials. Pharmacopsychiatry. 2023 Jan;56(1):18-24. doi: 10.1055/a-1841-6672. Epub 2022 Jul 27. PMID: 35896419.
Ketamine for the treatment of major depression: a systematic review and meta-analysis
Nikolin S, Rodgers A, Schwaab A, Bahji A, Zarate C Jr, Vazquez G, Loo C. Ketamine for the treatment of major depression: a systematic review and meta-analysis. EClinicalMedicine. 2023 Aug 3;62:102127. doi: 10.1016/j.eclinm.2023.102127. PMID: 37593223; PMCID: PMC10430179.
Trajectory of fecal lactoferrin for predicting prognosis in ulcerative colitis
Chen R, Li L, Tie Y, Chen M, Zhang S. Trajectory of fecal lactoferrin for predicting prognosis in ulcerative colitis. Precis Clin Med. 2023 Sep 5;6(3):pbad022. doi: 10.1093/pcmedi/pbad022. PMID: 38025971; PMCID: PMC10680133.
Prognostic Role of Dynamic Changes in Serological Markers in Metastatic Hormone Naïve Prostate Cancer
Roy S, Sun Y, Wallis CJD, Kishan AU, Morgan SC, Spratt DE, Malone S, Saad F. Prognostic Role of Dynamic Changes in Serological Markers in Metastatic Hormone Naïve Prostate Cancer. Cancers (Basel). 2023 Sep 2;15(17):4392. doi: 10.3390/cancers15174392. PMID: 37686668; PMCID: PMC10486494.
Psychiatric Adverse Events of Acetylcholinesterase Inhibitors in Alzheimer’s Disease and Parkinson’s Dementia: Systematic Review and Meta-Analysis
Bittner N, Funk CSM, Schmidt A, Bermpohl F, Brandl EJ, Algharably EEA, Kreutz R, Riemer TG. Psychiatric Adverse Events of Acetylcholinesterase Inhibitors in Alzheimer’s Disease and Parkinson’s Dementia: Systematic Review and Meta-Analysis. Drugs Aging. 2023 Nov;40(11):953-964. doi: 10.1007/s40266-023-01065-x. Epub 2023 Sep 8. PMID: 37682445; PMCID: PMC10600312.
Reconsidering “dissociation” as a predictor of antidepressant efficacy for esketamine
Mathai DS, Nayak SM, Yaden DB, Garcia-Romeu A. Reconsidering “dissociation” as a predictor of antidepressant efficacy for esketamine. Psychopharmacology (Berl). 2023 Apr;240(4):827-836. doi: 10.1007/s00213-023-06324-8. Epub 2023 Feb 2. PMID: 36729145.
Predicting Endoscopic Improvement in Ulcerative Colitis Using the Ulcerative Colitis Severity Index
Wong ECL, Dulai PS, Marshall JK, Jairath V, Reinisch W, Narula N. Predicting Endoscopic Improvement in Ulcerative Colitis Using the Ulcerative Colitis Severity Index. Inflamm Bowel Dis. 2023 Apr 28:izad074. doi: 10.1093/ibd/izad074. Epub ahead of print. PMID: 37116893.
Delayed Ustekinumab Responders in Ulcerative Colitis Have Greater Inflammatory Burden but Similar Outcomes as Early Responders
Wong ECL, Dulai PS, Marshall JK, Jairath V, Reinisch W, Narula N. Delayed Ustekinumab Responders in Ulcerative Colitis Have Greater Inflammatory Burden but Similar Outcomes as Early Responders. Clin Gastroenterol Hepatol. 2023 Jun 29:S1542-3565(23)00496-2. doi: 10.1016/j.cgh.2023.06.011. Epub ahead of print. PMID: 37391059.
Mediators between canagliflozin and renoprotection vary depending on patient characteristics: Insights from the CREDENCE trial
Doi Y, Hamano T, Yamaguchi S, Sakaguchi Y, Kaimori JY, Isaka Y. Mediators between canagliflozin and renoprotection vary depending on patient characteristics: Insights from the CREDENCE trial. Diabetes Obes Metab. 2023 Jun 29. doi: 10.1111/dom.15191. Epub ahead of print. PMID: 37385955.
Phenomapping-Derived Tool to Individualize the Effect of Canagliflozin on Cardiovascular Risk in Type 2 Diabetes
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