Neeraj Narula, Hasan Hamam, Jasmine Liu, Emily C L Wong, John K Marshall, Vipul Jairath, Stephen B Hanauer, Walter Reinisch, Parambir S Dulai, Adaptive steroid tapering impedes corticosteroid-free remissions compared to forced tapering in clinical trials of ulcerative colitis, Journal of Crohn’s and Colitis, 2024;, jjae092, https://doi.org/10.1093/ecco-jcc/jjae092
Featured Articles
Platelet-to-lymphocyte percentage ratio for assessing disease activity and predicting therapeutic outcomes in ulcerative colitis
Zheng J, Wang Y, Li L, Chen M, Chen R, Zhang S. Platelet-to-lymphocyte percentage ratio for assessing disease activity and predicting therapeutic outcomes in ulcerative colitis. Int Immunopharmacol. 2024 Jun 23;137:112506. doi: 10.1016/j.intimp.2024.112506. Epub ahead of print. PMID: 38914032.
Effects of newer anti-hyperglycemic agents on cardiovascular outcomes in older adults: Systematic review and meta-analysis
Bilal A, Yi F, Gonzalez GR, Ali M, Im K, Ruff CT, Thethi TK, Pratley RE. Effects of newer anti-hyperglycemic agents on cardiovascular outcomes in older adults: Systematic review and meta-analysis. J Diabetes Complications. 2024 Jun 8;38(8):108783. doi: 10.1016/j.jdiacomp.2024.108783. Epub ahead of print. PMID: 38870731.
Does Slow and Steady Win the Race? Rates of Antipsychotic Discontinuation, Antipsychotic Dose, and Risk of Psychotic Relapse
McCutcheon RA, Taylor D, Rubio J, Nour J, Pillinger T, Murray RM, Jauhar S. Does Slow and Steady Win the Race? Rates of Antipsychotic Discontinuation, Antipsychotic Dose, and Risk of Psychotic Relapse. Schizophr Bull. 2024 Apr 30;50(3):513-520. doi: 10.1093/schbul/sbad139. PMID: 37797288; PMCID: PMC11059789.
The impact of autoantibodies on the efficacy of biological disease-modifying anti-rheumatic drugs in rheumatoid arthritis: meta-analysis of randomized controlled trials
Takase-Minegishi K, Böhringer S, Nam JL, Kaneko Y, Behrens F, Saevarsdottir S, Detert J, Leirisalo-Repo M, van der Heijde D, Landewé R, Ramiro S, van der Woude D. The impact of autoantibodies on the efficacy of biological disease-modifying anti-rheumatic drugs in rheumatoid arthritis: meta-analysis of randomized controlled trials. Rheumatology (Oxford). 2024 Feb 16:keae113. doi: 10.1093/rheumatology/keae113. Epub ahead of print. PMID: 38366945.
Effect of Canagliflozin on Heart Failure Hospitalization in Diabetes According to Baseline Heart Failure Risk
Khan MS, Segar MW, Usman MS, Patel KV, Van Spall HGC, DeVore AD, Vaduganathan M, Lam CSP, Zannad F, Verma S, Butler J, Tang WHW, Pandey A. Effect of Canagliflozin on Heart Failure Hospitalization in Diabetes According to Baseline Heart Failure Risk. JACC Heart Fail. 2023 Jul;11(7):825-835. doi: 10.1016/j.jchf.2023.03.025. Epub 2023 May 24. PMID: 37227388.
Bedaquiline exposure in people with drug-resistant TB treatedfor diabetes: analysis of two phase 2 trials
Bolhuis MS, Akkerman OW, Sturkenboom MGG, van Boven JFM, Alffenaar JC, Stevens J. Bedaquiline exposure in people with drug-resistant TB treated for diabetes: analysis of two phase 2 trials. Int J Tuberc Lung Dis. 2023 Apr 1;27(4):335-337. doi: 10.5588/ijtld.22.0581. PMID: 37035978.
Identifying surrogate markers in real-world comparativeeffectiveness research
Han L, Wang X, Cai T. Identifying surrogate markers in real-world comparative effectiveness research. Stat Med. 2022 Nov 20;41(26):5290-5304. doi: 10.1002/sim.9569. Epub 2022 Sep 5. PMID: 36062392.
Impact of Asian Race on Prognosis inDe Novo Metastatic Prostate Cancer
Freedland SJ, Samjoo IA, Rosta E, Lansing A, Worthington E, Niyazov A, Nazari J, Arondekar B. The impact of race on survival in metastatic prostate cancer: a systematic literature review. Prostate Cancer Prostatic Dis. 2023 Sep;26(3):461-474. doi: 10.1038/s41391-023-00710-1. Epub 2023 Aug 17. PMID: 37592001; PMCID: PMC10449629.
Radiographic Progression Without Corresponding Prostate-specific Antigen Progression in Patients with Metastatic Castration-sensitive Prostate Cancer Receiving Apalutamide: Secondary Analysis of the TITAN Trial
Fukuokaya W, Yanagisawa T, Mori K, Urabe F, Rajwa P, Briganti A, Shariat SF, Kimura T. Radiographic Progression Without Corresponding Prostate-specific Antigen Progression in Patients with Metastatic Castration-sensitive Prostate Cancer Receiving Apalutamide: Secondary Analysis of the TITAN Trial. Eur Urol Oncol. 2024 Apr 29:S2588-9311(24)00101-9. doi: 10.1016/j.euo.2024.04.009. Epub ahead of print. PMID: 38688767
Impact of Asian Race on Prognosis in De Novo Metastatic Prostate Cancer
Ni X, Luu M, Ma W, Zhang T, Wei Y, Freedland SJ, Ye D, Daskivich TJ, Zhu Y. Impact of Asian Race on Prognosis in De Novo Metastatic Prostate Cancer. J Natl Compr Canc Netw. 2023 Jul;21(7):733-741.e3. doi: 10.6004/jnccn.2023.7027. PMID: 37433430.
Heterogeneity and Utility of Pharmaceutical Company Sharing of Individual-Participant Data Packages
Hopkins AM, Modi ND, Abuhelwa AY, Kichenadasse G, Kuderer NM, Lyman GH, Wiese MD, McKinnon RA, Rockhold FW, Mann A, Rowland A, Sorich MJ. Heterogeneity and Utility of Pharmaceutical Company Sharing of Individual-Participant Data Packages. JAMA Oncol. 2023 Dec 1;9(12):1621-1626. doi: 10.1001/jamaoncol.2023.3996. PMID: 37796495; PMCID: PMC10557028.
Association of proton pump inhibitor use with survival and adverse effects outcomes in patients with multiple myeloma: pooled analysis of three clinical trials
Almansour SA, Alqudah MAY, Abuhelwa Z, Al-Shamsi HO, Semreen MH, Bustanji Y, Soare NC, McKinnon RA, Sorich MJ, Hopkins AM, Abuhelwa AY. Association of proton pump inhibitor use with survival and adverse effects outcomes in patients with multiple myeloma: pooled analysis of three clinical trials. Sci Rep. 2024 Jan 5;14(1):591. doi: 10.1038/s41598-023-48640-1. PMID: 38182614; PMCID: PMC10770405.
Rapidly achieving clinical remission in ulcerative colitis indicates better endoscopic and histological outcomes
Chen R, Tie Y, Huang Y, Zhang X, Zeng Z, Chen M, Li L, Zhang S. Rapidly achieving clinical remission in ulcerative colitis indicates better endoscopic and histological outcomes. United European Gastroenterol J. 2023 Dec 30. doi: 10.1002/ueg2.12515. Epub ahead of print. PMID: 38159047.
Illusory generalizability of clinical prediction models
Chekroud AM, Hawrilenko M, Loho H, Bondar J, Gueorguieva R, Hasan A, Kambeitz J, Corlett PR, Koutsouleris N, Krumholz HM, Krystal JH, Paulus M. Illusory generalizability of clinical prediction models. Science. 2024 Jan 12;383(6679):164-167. doi: 10.1126/science.adg8538. Epub 2024 Jan 11. PMID: 38207039.
Combining Real-World and Randomized Control Trial Data Using Data-Adaptive
Harton J, Segal B, Mamtani R, Mitra N, Hubbard RA. Combining real-world and randomized control trial data using data-adaptive weighting via the on-trial score. Statistics in Biopharmaceutical Research. 2022;15(2):408–20. doi:10.1080/19466315.2022.2071982
Association between concomitant proton pump inhibitor use and survival of patients with metastatic prostate cancer receiving abiraterone acetate: a post-hoc analysis of pooled data from three randomized controlled trials
Fukuokaya W, Mori K, Yanagisawa T, Akazawa K, Shimomura T, Kimura T. Association between concomitant proton pump inhibitor use and survival of patients with metastatic prostate cancer receiving abiraterone acetate: a post-hoc analysis of pooled data from three randomized controlled trials. Prostate Cancer Prostatic Dis. 2023 Jul 18. doi: 10.1038/s41391-023-00695-x. Epub ahead of print. PMID: 37464102.
A powerful partnership: researchers and patients working together to develop a patient-facing summary of clinical trial outcome data
Ruzich E, Ritchie J, Ginchereau Sowell F, et al. A powerful partnership: researchers and patients working together to develop a patient-facing summary of clinical trial outcome data. Journal of the American Medical Informatics Association : JAMIA. 2023 Jun:ocad099. DOI: 10.1093/jamia/ocad099. PMID: 37341698.
Linkage of Young Mania Rating Scale to Clinical Global Impression Scale to Enhance Utility in Clinical Practice and Research Trials
Samara MT, Levine SZ, Leucht S. Linkage of Young Mania Rating Scale to Clinical Global Impression Scale to Enhance Utility in Clinical Practice and Research Trials. Pharmacopsychiatry. 2023 Jan;56(1):18-24. doi: 10.1055/a-1841-6672. Epub 2022 Jul 27. PMID: 35896419.
Ketamine for the treatment of major depression: a systematic review and meta-analysis
Nikolin S, Rodgers A, Schwaab A, Bahji A, Zarate C Jr, Vazquez G, Loo C. Ketamine for the treatment of major depression: a systematic review and meta-analysis. EClinicalMedicine. 2023 Aug 3;62:102127. doi: 10.1016/j.eclinm.2023.102127. PMID: 37593223; PMCID: PMC10430179.
Trajectory of fecal lactoferrin for predicting prognosis in ulcerative colitis
Chen R, Li L, Tie Y, Chen M, Zhang S. Trajectory of fecal lactoferrin for predicting prognosis in ulcerative colitis. Precis Clin Med. 2023 Sep 5;6(3):pbad022. doi: 10.1093/pcmedi/pbad022. PMID: 38025971; PMCID: PMC10680133.
Prognostic Role of Dynamic Changes in Serological Markers in Metastatic Hormone Naïve Prostate Cancer
Roy S, Sun Y, Wallis CJD, Kishan AU, Morgan SC, Spratt DE, Malone S, Saad F. Prognostic Role of Dynamic Changes in Serological Markers in Metastatic Hormone Naïve Prostate Cancer. Cancers (Basel). 2023 Sep 2;15(17):4392. doi: 10.3390/cancers15174392. PMID: 37686668; PMCID: PMC10486494.
Psychiatric Adverse Events of Acetylcholinesterase Inhibitors in Alzheimer’s Disease and Parkinson’s Dementia: Systematic Review and Meta-Analysis
Bittner N, Funk CSM, Schmidt A, Bermpohl F, Brandl EJ, Algharably EEA, Kreutz R, Riemer TG. Psychiatric Adverse Events of Acetylcholinesterase Inhibitors in Alzheimer’s Disease and Parkinson’s Dementia: Systematic Review and Meta-Analysis. Drugs Aging. 2023 Nov;40(11):953-964. doi: 10.1007/s40266-023-01065-x. Epub 2023 Sep 8. PMID: 37682445; PMCID: PMC10600312.
Reconsidering “dissociation” as a predictor of antidepressant efficacy for esketamine
Mathai DS, Nayak SM, Yaden DB, Garcia-Romeu A. Reconsidering “dissociation” as a predictor of antidepressant efficacy for esketamine. Psychopharmacology (Berl). 2023 Apr;240(4):827-836. doi: 10.1007/s00213-023-06324-8. Epub 2023 Feb 2. PMID: 36729145.
Predicting Endoscopic Improvement in Ulcerative Colitis Using the Ulcerative Colitis Severity Index
Wong ECL, Dulai PS, Marshall JK, Jairath V, Reinisch W, Narula N. Predicting Endoscopic Improvement in Ulcerative Colitis Using the Ulcerative Colitis Severity Index. Inflamm Bowel Dis. 2023 Apr 28:izad074. doi: 10.1093/ibd/izad074. Epub ahead of print. PMID: 37116893.
Delayed Ustekinumab Responders in Ulcerative Colitis Have Greater Inflammatory Burden but Similar Outcomes as Early Responders
Wong ECL, Dulai PS, Marshall JK, Jairath V, Reinisch W, Narula N. Delayed Ustekinumab Responders in Ulcerative Colitis Have Greater Inflammatory Burden but Similar Outcomes as Early Responders. Clin Gastroenterol Hepatol. 2023 Jun 29:S1542-3565(23)00496-2. doi: 10.1016/j.cgh.2023.06.011. Epub ahead of print. PMID: 37391059.
Mediators between canagliflozin and renoprotection vary depending on patient characteristics: Insights from the CREDENCE trial
Doi Y, Hamano T, Yamaguchi S, Sakaguchi Y, Kaimori JY, Isaka Y. Mediators between canagliflozin and renoprotection vary depending on patient characteristics: Insights from the CREDENCE trial. Diabetes Obes Metab. 2023 Jun 29. doi: 10.1111/dom.15191. Epub ahead of print. PMID: 37385955.
Phenomapping-Derived Tool to Individualize the Effect of Canagliflozin on Cardiovascular Risk in Type 2 Diabetes
Oikonomou EK, Suchard MA, McGuire DK, Khera R. Phenomapping-Derived Tool to Individualize the Effect of Canagliflozin on Cardiovascular Risk in Type 2 Diabetes. Diabetes Care. 2022 Apr 1;45(4):965-974. doi: 10.2337/dc21-1765. PMID: 35120199; PMCID: PMC9016734.
Cholinesterase Inhibitors for Treatment of Psychotic Symptoms in Alzheimer Disease and Parkinson Disease
d’Angremont E, Begemann MJH, van Laar T, Sommer IEC. Cholinesterase Inhibitors for Treatment of Psychotic Symptoms in Alzheimer Disease and Parkinson Disease: A Meta-analysis. JAMA Neurol. 2023 Aug 1;80(8):813-823. doi: 10.1001/jamaneurol.2023.1835. PMID: 37358841; PMCID: PMC10294019.
Fecal lactoferrin early predicts long-term outcomes in ulcerative colitis: A post-hoc analysis of the UNIFI and PURSUIT trials
Chen R, Tie Y, Zhang X, Li L, Chen M, Zhang S. Fecal lactoferrin early predicts long-term outcomes in ulcerative colitis: A post-hoc analysis of the UNIFI and PURSUIT trials. United European Gastroenterol J. 2023 Jun 23. doi: 10.1002/ueg2.12431. Epub ahead of print. PMID: 37350349.
Rapidity of Symptom Improvement With Intranasal Esketamine for Major Depressive Disorder: A Systematic Review and Meta-Analysis
Hock RS, Feeney A, Iovieno N, et al. Rapidity of symptom improvement with intranasal esketamine for major depressive disorder: a systematic review and meta-analysis. J Clin Psychiatry. 2023;84(1):21r14086.
Canagliflozin and Metabolic Associated Fatty Liver Disease in Patients with Diabetes Mellitus: New Insights from CANVAS
Borisov AN, Kutz A, Christ ER, Heim MH, Ebrahimi F. Canagliflozin and Metabolic Associated Fatty Liver Disease in Patients with Diabetes Mellitus: New Insights from CANVAS. J Clin Endocrinol Metab. 2023 May 7:dgad249. doi: 10.1210/clinem/dgad249. Epub ahead of print. PMID: 37149821.
Comparative Efficacy of Infliximab Versus Tofacitinib for Inducing Remission in Biologic Naive Ulcerative Colitis: A Propensity Matched Study
Wong, E.C.L., Merat, S., Monaco, C. et al. Comparative Efficacy of Infliximab Versus Tofacitinib for Inducing Remission in Biologic Naive Ulcerative Colitis: A Propensity Matched Study. Dig Dis Sci 68, 2635–2646 (2023). https://doi.org/10.1007/s10620-023-07956-8
External Validation of a Prognostic Model of Overall Survival in Men With Chemotherapy-Naïve Metastatic Castration-Resistant Prostate Cancer
Halabi S, Yang Q, Roy A, Luo B, Araujo JC, Logothetis C, Sternberg CN, Armstrong AJ, Carducci MA, Chi KN, de Bono JS, Petrylak DP, Fizazi K, Higano CS, Morris MJ, Rathkopf DE, Saad F, Ryan CJ, Small EJ, Kelly WK. External Validation of a Prognostic Model of Overall Survival in Men With Chemotherapy-Naïve Metastatic Castration-Resistant Prostate Cancer. J Clin Oncol. 2023 Apr 11:JCO2202661. doi: 10.1200/JCO.22.02661. Epub ahead of print. PMID: 37040594.
Metabolic side effects in persons with schizophrenia during mid- to long-term treatment with antipsychotics: a network meta-analysis of randomized controlled trials.
Burschinski A, Schneider-Thoma J, Chiocchia V, Schestag K, Wang D, Siafis S, Bighelli I, Wu H, Hansen WP, Priller J, Davis JM, Salanti G, Leucht S. Metabolic side effects in persons with schizophrenia during mid- to long-term treatment with antipsychotics: a network meta-analysis of randomized controlled trials. World Psychiatry. 2023 Feb;22(1):116-128. doi: 10.1002/wps.21036. PMID: 36640396; PMCID: PMC9840505.
Guiding safer risperidone prescribing in Alzheimer’s disease with therapeutic drug monitoring
Roughley, M, Mena, C, Howard, R, Reeves, S, Bertrand, J. Guiding safer risperidone prescribing in Alzheimer’s disease with therapeutic drug monitoring. Br J Clin Pharmacol. 2023; 1- 6. doi:10.1111/bcp.15692
External control arm analysis: an evaluation of propensity score approaches, G-computation, and doubly debiased machine learning
Loiseau, N., Trichelair, P., He, M. et al. External control arm analysis: an evaluation of propensity score approaches, G-computation, and doubly debiased machine learning. BMC Med Res Methodol 22, 335 (2022). https://doi.org/10.1186/s12874-022-01799-z
Comparative safety and efficacy of cognitive enhancers for Alzheimer’s dementia: a systematic review with individual patient data network meta-analysis
Veroniki AA, Ashoor HM, Rios P, et al Comparative safety and efficacy of cognitive enhancers for Alzheimer’s dementia: a systematic review with individual patient data network meta-analysis BMJ Open 2022;12:e053012. doi: 10.1136/bmjopen-2021-053012
Depicting Risperidone Safety Profiles in Clinical Trials Across Different Diagnoses Using a Dopamine D2-Based Pharmacological Class Effect Query Defined by FAERS
Hopkins, S.C., Ogirala, A., Zeni, C. et al. Depicting Risperidone Safety Profiles in Clinical Trials Across Different Diagnoses Using a Dopamine D2-Based Pharmacological Class Effect Query Defined by FAERS. Clin Drug Investig 42, 1113–1121 (2022). https://doi.org/10.1007/s40261-022-01218-7
Effect of Prior Local Therapy on Response to First-line Androgen Receptor Axis Targeted Therapy in Metastatic Castrate-resistant Prostate Cancer: A Secondary Analysis of the COU-AA-302 Trial
S. Roy, Y. Sun, S.C. Morgan et al., Effect of Prior Local Therapy on Response to First-line Androgen Receptor Axis Targeted Therapy in Metastatic Castrate-resistant Prostate Cancer: A Secondary Analysis of the COU-AA-302 Trial, Eur Urol (2023), https://doi.org/10.1016/j. eururo.2023.02.017
Predicting psychotic relapse following randomised discontinuation of paliperidone in individuals with schizophrenia or schizoaffective disorder: an individual participant data analysis
Brandt, L., et al. (2023). “Predicting psychotic relapse following randomised discontinuation of paliperidone in individuals with schizophrenia or schizoaffective disorder: an individual participant data analysis.” The Lancet Psychiatry 10(3): 184-196.
Data-sharing and re-analysis for main studies assessed by the European Medicines Agency—a cross-sectional study on European Public Assessment Reports
Siebert M, Gaba J, Renault A, Laviolle B, Locher C, Moher D, Naudet F. Data-sharing and re-analysis for main studies assessed by the European Medicines Agency-a cross-sectional study on European Public Assessment Reports. BMC Med. 2022 May 20;20(1):177. doi: 10.1186/s12916-022-02377-2. PMID: 35590360; PMCID: PMC9119701.
Higher Postinduction Infliximab Concentrations Are Associated With Improved Clinical Outcomes in Fistulizing Crohn’s Disease: An ACCENT-II Post Hoc Analysis
Papamichael K, Vande Casteele N, Jeyarajah J, Jairath V, Osterman MT, Cheifetz AS. Higher Postinduction Infliximab Concentrations Are Associated With Improved Clinical Outcomes in Fistulizing Crohn’s Disease: An ACCENT-II Post Hoc Analysis. Am J Gastroenterol. 2021 May 1;116(5):1007-1014. doi: 10.14309/ajg.0000000000001111. PMID: 33929379; PMCID: PMC8095681.
Higher post-induction infliximab concentrations are associated with improved clinical outcomes in fistulizing Crohn’s disease: an ACCENT-II post-hoc analysis
Papamichael K, Vande Casteele N, Jeyarajah J, Jairath V, Osterman MT, Cheifetz AS. Higher Postinduction Infliximab Concentrations Are Associated With Improved Clinical Outcomes in Fistulizing Crohn’s Disease: An ACCENT-II Post Hoc Analysis. Am J Gastroenterol. 2021 May 1;116(5):1007-1014. doi: 10.14309/ajg.0000000000001111. PMID: 33929379; PMCID: PMC8095681.
A Microsimulation Model to Determine the Cost-Effectiveness of Treat-to-Target Strategies for Crohn’s Disease
Dulai PS, Jairath V, Narula N, Wong E, Kochhar GS, Colombel JF, Sandborn WJ. A Microsimulation Model to Determine the Cost-Effectiveness of Treat-to-Target Strategies for Crohn’s Disease. Am J Gastroenterol. 2021 Aug 1;116(8):1709-1719. doi: 10.14309/ajg.0000000000001263. PMID: 34587127; PMCID: PMC8481677.
Vibration of effect in more than 16 000 pooled analyses of individual participant data from 12 randomised controlled trials comparing canagliflozin and placebo for type 2 diabetes mellitus: multiverse analysis
Gouraud H, Wallach JD, Boussageon R, et al Vibration of effect in more than 16 000 pooled analyses of individual participant data from 12 randomised controlled trials comparing canagliflozin and placebo for type 2 diabetes mellitus: multiverse analysis
BMJ Medicine 2022;1:e000154. doi: 10.1136/bmjmed-2022-000154
Reappraising the variability of effects of antipsychotic medication in schizophrenia: a meta-analysis
McCutcheon RA, Pillinger T, Efthimiou O, Maslej M, Mulsant BH, Young AH, Cipriani A, Howes OD. Reappraising the variability of effects of antipsychotic medication in schizophrenia: a meta-analysis. World Psychiatry. 2022 Jun;21(2):287-294. doi: 10.1002/wps.20977. PMID: 35524614; PMCID: PMC9077611.
Predictors of Placebo Induction Response and Remission in Ulcerative Colitis
Wong ECL, Dulai PS, Marshall JK, Jairath V, Reinisch W, Narula N. Predictors of Placebo Induction Response and Remission in Ulcerative Colitis. Clin Gastroenterol Hepatol. 2022 Aug 24:S1542-3565(22)00811-4. doi: 10.1016/j.cgh.2022.08.015. Epub ahead of print. PMID: 36029969.
Impact of pre-existing background therapy on placebo responses in randomised controlled clinical trials of rheumatoid arthritis
Kerschbaumer A, Rivai ZI, Smolen JS, et al Impact of pre-existing background therapy on placebo responses in randomised controlled clinical trials of rheumatoid arthritis. Annals of the Rheumatic Diseases Published Online First: 20 June 2022. doi: 10.1136/annrheumdis-2021-221807
The efficacy of canagliflozin in diabetes subgroups stratified by data-driven clustering or a supervised machine learning method: a post hoc analysis of canagliflozin clinical trial data
Zou X, Huang Q, Luo Y, Ren Q, Han X, Zhou X, Ji L. The efficacy of canagliflozin in diabetes subgroups stratified by data-driven clustering or a supervised machine learning method: a post hoc analysis of canagliflozin clinical trial data. Diabetologia. 2022 Jul 8. doi: 10.1007/s00125-022-05748-9. Epub ahead of print. PMID: 35802168.
Comparative Effectiveness of Biologics for Endoscopic Healing of the Ileum and Colon in Crohn’s Disease
Narula, Neeraj MD, MPH, FRCPC1; Wong, Emily C.L. BHSc1; Dulai, Parambir S. MD2; Marshall, John K. MD, MSc, FRCPC1; Jairath, Vipul MD, PhD3; Reinisch, Walter MD, PhD4 Comparative Effectiveness of Biologics for Endoscopic Healing of the Ileum and Colon in Crohn’s Disease, The American Journal of Gastroenterology: April 15, 2022 – Volume – Issue – 10.14309/ajg.0000000000001795 doi: 10.14309/ajg.0000000000001795
Gender-Based Differences in Response to Tumor Necrosis Factor Inhibitor Therapies for Ulcerative Colitis: Individual Participant Data Meta-Analyses of Clinical Trials.
Agrawal, Manasi & Petralia, Francesca & Tepler, Adam & Durbin, Laura & Reinisch, Walter & Colombel, Jean-Frederic & Shah, Shailja. (2022). Gender-Based Differences in Response to Tumor Necrosis Factor Inhibitor Therapies for Ulcerative Colitis: Individual Participant Data Meta-Analyses of Clinical Trials. Inflammatory Bowel Diseases. 10.1093/ibd/izac067.
Cardiovascular benefits of GLP-1RA and SGLT-2i in women with type 2 diabetes
Mishriky BM, Cummings DM, Powell JR. Cardiovascular benefits of GLP-1RA and SGLT-2i in women with type 2 diabetes. Prim Care Diabetes. 2022 Apr 5:S1751-9918(22)00073-0. doi: 10.1016/j.pcd.2022.03.012. Epub ahead of print. PMID: 35396200.
Three-Month FVC Change: A Trial Endpoint for IPF Based on Individual Participant Data Meta-Analysis
Khan FA, Stewart I, Moss S, Fabbri L, Robinson KA, Johnson SR, Jenkins RG. Three-Month FVC Change: A Trial Endpoint for IPF Based on Individual Participant Data Meta-Analysis. Am J Respir Crit Care Med. 2022 Jan 12. doi: 10.1164/rccm.202109-2091OC. Epub ahead of print. PMID: 35020580.
Comparing current and emerging practice models for the extrapolation of survival data: a simulation study and case-study
Kearns B, Stevenson MD, Triantafyllopoulos K, Manca A. Comparing current and emerging practice models for the extrapolation of survival data: a simulation study and case-study. BMC Med Res Methodol. 2021 Nov 27;21(1):263. doi: 10.1186/s12874-021-01460-1. PMID: 34837957; PMCID: PMC8627632.
Early Reduction in MM-SES-CD Score After Initiation of Biologic Therapy is Highly Specific for One-Year Endoscopic Remission in Moderate to Severe Crohn’s Disease
Narula N, Wong ECL, Colombel JF, Sandborn WJ, Ferrante M, Marshall JK, Reinisch W, Dulai PS. Early Reduction in MM-SES-CD Score After Initiation of Biologic Therapy is Highly Specific for One-Year Endoscopic Remission in Moderate to Severe Crohn’s Disease. J Crohns Colitis. 2021 Oct 19:jjab183. doi: 10.1093/ecco-jcc/jjab183. Epub ahead of print. PMID: 34664635.
Categorizing Endoscopic Severity of Crohn’s Disease Using the Modified Multiplier SES-CD (MM-SES-CD)
Narula N, Pray C, Wong ECL, Colombel JF, Marshall JK, Daperno M, Reinisch W, Dulai PS. Categorizing Endoscopic Severity of Crohn’s Disease Using the Modified Multiplier SES-CD (MM-SES-CD). J Crohns Colitis. 2022 Feb 3:jjac018. doi: 10.1093/ecco-jcc/jjac018. Epub ahead of print. PMID: 35134140.
Explainable AI enables clinical trial patient selection to retrospectively improve treatment effects in schizophrenia
Mellem MS, Kollada M, Tiller J, Lauritzen T. Explainable AI enables clinical trial patient selection to retrospectively improve treatment effects in schizophrenia. BMC Med Inform Decis Mak. 2021 May 20;21(1):162. doi: 10.1186/s12911-021-01510-0. PMID: 34016112; PMCID: PMC8135147.
Combination of statin/vitamin D and metastatic castration-resistant prostate cancer (CRPC): a post hoc analysis of two randomized clinical trials
Carretero-González A, Lora D, Manneh R, Lorente D, Castellano D, de Velasco G. Combination of statin/vitamin D and metastatic castration-resistant prostate cancer (CRPC): a post hoc analysis of two randomized clinical trials. Clin Transl Oncol. 2020 Nov;22(11):2126-2129. doi: 10.1007/s12094-020-02334-6. Epub 2020 Mar 20. PMID: 32198642.
Predicting Probability of Response to Tumor Necrosis Factor Inhibitors for Individual Patients With Ankylosing Spondylitis
Wang R, Dasgupta A, Ward MM. Predicting Probability of Response to Tumor Necrosis Factor Inhibitors for Individual Patients With Ankylosing Spondylitis. JAMA Netw Open. 2022;5(3):e222312. doi:10.1001/jamanetworkopen.2022.2312
Early versus late response to daratumumab-based triplet therapies in patients with multiple myeloma: a pooled analysis of trials POLLUX, CASTOR and MAIA
Wang J, Arroyo-Suarez R, Dasari S, Sekaran K, Tse W. Early versus late response to daratumumab-based triplet therapies in patients with multiple myeloma: a pooled analysis of trials POLLUX, CASTOR and MAIA. Leuk Lymphoma. 2022 Feb 10:1-9. doi: 10.1080/10428194.2022.2038376. Epub ahead of print. PMID: 35142582.
Resolution of dominant patient-reported outcome at end of induction predicts clinical and endoscopic remission in Crohn’s disease
Wong ECL, Dulai PS, Marshall JK, Jairath V, Reinisch W, Narula N. Resolution of dominant patient-reported outcome at end of induction predicts clinical and endoscopic remission in Crohn’s disease. Aliment Pharmacol Ther. 2022 Feb 15. doi: 10.1111/apt.16805. Epub ahead of print. PMID: 35166396.
Adverse events after antipsychotic discontinuation: an individual participant data meta-analysis
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