array(43) {
  ["project_title"]=>
  string(135) "Development of a Clinical Prediction Tool for Treatment Outcomes in Infliximab-treated Patients with Moderate-Severe Ulcerative Colitis"
  ["project_narrative_summary"]=>
  string(585) "Several biologic and small molecule therapies are available for the management of patients with moderate-severe ulcerative colitis (UC). However, there is limited data to inform optimal positioning and personalization of these therapies. We propose to identify factors predictive of response to infliximab, develop a prediction model and transform it into a simple to use prognostic clinical decision support tool to identify patients most, and least, likely to respond to these therapies. To develop the model, we will analyze phase III, placebo-controlled trials of infliximab in UC."
  ["project_learn_source"]=>
  string(12) "scien_public"
  ["project_learn_source_exp"]=>
  string(0) ""
  ["project_key_personnel"]=>
  array(2) {
    [0]=>
    array(6) {
      ["p_pers_f_name"]=>
      string(8) "Parambir"
      ["p_pers_l_name"]=>
      string(5) "Dulai"
      ["p_pers_degree"]=>
      string(2) "MD"
      ["p_pers_pr_affil"]=>
      string(34) "University of California San Diego"
      ["p_pers_scop_id"]=>
      string(11) "53463435600"
      ["requires_data_access"]=>
      string(0) ""
    }
    [1]=>
    array(6) {
      ["p_pers_f_name"]=>
      string(5) "James"
      ["p_pers_l_name"]=>
      string(9) "Proudfoot"
      ["p_pers_degree"]=>
      string(2) "MS"
      ["p_pers_pr_affil"]=>
      string(34) "University of California San Diego"
      ["p_pers_scop_id"]=>
      string(11) "57038204000"
      ["requires_data_access"]=>
      string(0) ""
    }
  }
  ["project_ext_grants"]=>
  array(2) {
    ["value"]=>
    string(2) "no"
    ["label"]=>
    string(68) "No external grants or funds are being used to support this research."
  }
  ["project_funding_source"]=>
  string(0) ""
  ["project_assoc_trials"]=>
  array(3) {
    [0]=>
    object(WP_Post)#4665 (24) {
      ["ID"]=>
      int(1114)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 10:31:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 10:31:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(159) "NCT00036439 - A Randomized, Placebo-controlled, Double-blind Trial to Evaluate the Safety and Efficacy of Infliximab in Patients With Active Ulcerative Colitis"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(155) "nct00036439-a-randomized-placebo-controlled-double-blind-trial-to-evaluate-the-safety-and-efficacy-of-infliximab-in-patients-with-active-ulcerative-colitis"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-04-22 10:28:16"
      ["post_modified_gmt"]=>
      string(19) "2024-04-22 14:28:16"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(204) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00036439-a-randomized-placebo-controlled-double-blind-trial-to-evaluate-the-safety-and-efficacy-of-infliximab-in-patients-with-active-ulcerative-colitis/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [1]=>
    object(WP_Post)#4664 (24) {
      ["ID"]=>
      int(1117)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 10:36:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 10:36:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(159) "NCT00096655 - A Randomized, Placebo-controlled, Double-blind Trial to Evaluate the Safety and Efficacy of Infliximab in Patients With Active Ulcerative Colitis"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(155) "nct00096655-a-randomized-placebo-controlled-double-blind-trial-to-evaluate-the-safety-and-efficacy-of-infliximab-in-patients-with-active-ulcerative-colitis"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-11-30 15:33:15"
      ["post_modified_gmt"]=>
      string(19) "2023-11-30 20:33:15"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(204) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00096655-a-randomized-placebo-controlled-double-blind-trial-to-evaluate-the-safety-and-efficacy-of-infliximab-in-patients-with-active-ulcerative-colitis/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [2]=>
    object(WP_Post)#4663 (24) {
      ["ID"]=>
      int(1957)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-02-13 13:59:00"
      ["post_date_gmt"]=>
      string(19) "2015-02-13 13:59:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(201) "NCT00537316 - Efficacy & Safety of Infliximab Monotherapy Vs Combination Therapy Vs AZA Monotherapy in Ulcerative Colitis (Part 1) Maintenance Vs Intermittent Therapy for Maintaining Remission (Part 2)"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(5) "draft"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(193) "nct00537316-efficacy-safety-of-infliximab-monotherapy-vs-combination-therapy-vs-aza-monotherapy-in-ulcerative-colitis-part-1-maintenance-vs-intermittent-therapy-for-maintaining-remission-part-2"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:30:16"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:30:16"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(70) "https://dev-yoda.pantheonsite.io/?post_type=clinical_trial&p=1957"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
  }
  ["project_date_type"]=>
  string(18) "full_crs_supp_docs"
  ["property_scientific_abstract"]=>
  string(1262) "Background: Clinical decision support tools Clinical prediction models provide insight into the impact of patient characteristics on treatment outcomes, allowing for a more personalized treatment.

Objective: To identify factors predictive of response to infliximab (IFX), develop a prediction model and transform it into a clinical decision support tool to identify patients most, and least, likely to respond to these therapies

Study Design: Individual participant level pooled analysis of RCTs of IFX in patients with UC

Participants: Patients enrolled in phase III RCTs of IFX in moderate-severe UC

Main Outcome Measures: Clinical remission, endoscopic remission, and deep remission (clinical remission + endoscopic remission) at week 30

Statistical Analysis: We will use multivariable logistic regression to develop models predicting each of the three outcomes at week 30, then transform it into a single model, and develop a simple to use clinical decision support tool, by multiplying the ? coefficient by 10 and rounding to the nearest value. Overall performance of the models was evaluated using area under the ROC curve. This model will then be validated in an external real-world cohort, outside of the YODA platform."
  ["project_brief_bg"]=>
  string(1987) "Several biologic and small molecule therapies are available (or anticipated to be available soon) for the management of patients with moderate-severe UC. However, there is limited data to inform optimal positioning and personalization of these therapies. Clinical prediction models utilize baseline characteristics to provide an estimate of the value of a therapy on treatment outcomes for an individual patient. Furthermore, the transformation of these models into decision support tools facilitates their application as a component of ?precision medicine?. With the evolving landscape of biologic therapy in UC and increasing treatment choice, a validated prognostic tool for treatment outcomes with IFX would be of considerable value. We aim to address this gap by deriving and validating a multivariable clinical prediction model within the ACT-1 and ACT-2 clinical trial dataset. To improve the ease with which this prediction model can be used at the ?bedside?, we will transform it into a prognostic clinical decision support tool (CDST) and validated this tool in a cohort of UC patients treated with IFX in routine clinical practice. We have created a similar CDST to inform use of vedolizumab in patients with moderate-severe UC.

The significance of this work lies in developing and validating an easy-to-use CDST to identify patients with moderate-severe UC most, and least, likely to respond to infliximab. The information generated through this study would be invaluable to inform both science and patient care. From a scientific perspective, it will help identify clinical factors associated with response to infliximab, which can then be used to further understand how these drugs may be effective. From a clinical perspective, information generated from this study on treatment response to infliximab, will be generalizable and directly applicable to patient care, informing clinical guidelines and offering potential for promoting value-based in patients with UC."
  ["project_specific_aims"]=>
  string(461) "Specific aim #1: To identify factors predictive of response to infliximab in patients with UC, through post-hoc analysis of phase III RCTs of IFX in UC.

Specific aim #2: To develop (and subsequently) validate a prediction model to identify patients with UC most, and least, likely to respond to IFX.

Hypothesis: Short disease duration, lower inflammatory burden and higher albumin are associated with increased likelihood of response to infliximab"
  ["project_study_design"]=>
  string(0) ""
  ["project_study_design_exp"]=>
  string(0) ""
  ["project_purposes"]=>
  array(0) {
  }
  ["project_purposes_exp"]=>
  string(0) ""
  ["project_software_used"]=>
  string(0) ""
  ["project_software_used_exp"]=>
  string(0) ""
  ["project_research_methods"]=>
  string(535) "Data sources:

?	Trial of infliximab in ulcerative colitis (C0168T37, C0168T46, C0168T72)

Inclusion criteria:

?	Patients (adults or pediatric) with moderate-severe ulcerative colitis (defined as Mayo Clinic score [MCS] of 6 to 12 points, with an endoscopic sub-score of 2 or 3)

?	Treated with infliximab or placebo for induction and/or maintenance

Exclusion criteria

?	Patients lost to follow-up or did not participate in trial after randomization (without receiving any dose of the medication)"
  ["project_main_outcome_measure"]=>
  string(280) "?	Primary outcome ? clinical remission (MCS?2, with no individual sub-score exceeding 1) at week 30

?	Secondary outcomes ? clinical remission at week 8, endoscopic remission at week 8 and 30 (absolute endoscopy sub-score on MCS of 0 or 1), steroid-free remission at week 30"
  ["project_main_predictor_indep"]=>
  string(73) "?	Main predictor/independent variable will be exposure to IFX vs. placebo"
  ["project_other_variables_interest"]=>
  string(163) "Key confounding variables of interest in our study are:

o	Biochemical measures of disease severity ? baseline C-reactive protein as a categorical variable ("
  ["project_stat_analysis_plan"]=>
  string(183) "A multivariable logistic regression prediction model will be built in the ACT-1 and -2 for the outcome of clinical remission at week 30. All baseline variables found to have a p value"
  ["project_timeline"]=>
  string(257) "o	Project start date: June 1, 2018

o	Analysis completion date: November 1, 2018

o	Manuscript drafted: January 1, 2019

o	Manuscript submitted for publication: January 31, 2019

o	Date results reported back to YODA: January 31, 2019"
  ["project_dissemination_plan"]=>
  string(382) "We anticipate generation of one manuscript from this project on the development and validation of a clinical prediction model for response to infliximab in patients with UC. The target audience would be clinical gastroenterologists. Potentially suitable journals for this manuscript would be: Gastroenterology, Gut, American Journal of Gastroenterology, Inflammatory Bowel Diseases."
  ["project_bibliography"]=>
  string(1114) "
1. Rutgeerts P, Sandborn WJ, Feagan BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2005 Dec 8;353(23):2462-76

2. Dulai PS, Singh S, Jiang X, Peerani F, Narula N, Chaudrey K, et al. The Real-World Effectiveness and Safety of Vedolizumab for Moderate-Severe Crohn’s Disease: Results From the US VICTORY Consortium. Am J Gastroenterol. 2016;111(8):1147-55.

3. Collins GS, Reitsma JB, Altman DG, Moons KG. Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD): the TRIPOD statement. Annals of internal medicine. 2015;162(1):55-63.

4. Steyerberg EW, Vickers AJ, Cook NR, Gerds T, Gonen M, Obuchowski N, et al. Assessing the performance of prediction models: a framework for traditional and novel measures. Epidemiology (Cambridge, Mass). 2010;21(1):128-38.

5. Hu MY, Katchar K, Kyne L, Maroo S, Tummala S, Dreisbach V, et al. Prospective derivation and validation of a clinical prediction rule for recurrent Clostridium difficile infection. Gastroenterology. 2009;136(4):1206-14.
"
  ["project_suppl_material"]=>
  bool(false)
  ["project_coi"]=>
  array(3) {
    [0]=>
    array(1) {
      ["file_coi"]=>
      array(21) {
        ["ID"]=>
        int(8694)
        ["id"]=>
        int(8694)
        ["title"]=>
        string(13) "coi_-_dulaips"
        ["filename"]=>
        string(17) "coi_-_dulaips.pdf"
        ["filesize"]=>
        int(1008367)
        ["url"]=>
        string(66) "https://yoda.yale.edu/wp-content/uploads/2017/09/coi_-_dulaips.pdf"
        ["link"]=>
        string(59) "https://yoda.yale.edu/data-request/2018-3061/coi_-_dulaips/"
        ["alt"]=>
        string(0) ""
        ["author"]=>
        string(4) "1363"
        ["description"]=>
        string(0) ""
        ["caption"]=>
        string(0) ""
        ["name"]=>
        string(13) "coi_-_dulaips"
        ["status"]=>
        string(7) "inherit"
        ["uploaded_to"]=>
        int(4532)
        ["date"]=>
        string(19) "2023-07-31 15:05:51"
        ["modified"]=>
        string(19) "2023-08-01 01:08:38"
        ["menu_order"]=>
        int(0)
        ["mime_type"]=>
        string(15) "application/pdf"
        ["type"]=>
        string(11) "application"
        ["subtype"]=>
        string(3) "pdf"
        ["icon"]=>
        string(62) "https://yoda.yale.edu/wp/wp-includes/images/media/document.png"
      }
    }
    [1]=>
    array(1) {
      ["file_coi"]=>
      array(21) {
        ["ID"]=>
        int(8701)
        ["id"]=>
        int(8701)
        ["title"]=>
        string(12) "coi_-_singhs"
        ["filename"]=>
        string(16) "coi_-_singhs.pdf"
        ["filesize"]=>
        int(199145)
        ["url"]=>
        string(65) "https://yoda.yale.edu/wp-content/uploads/2017/05/coi_-_singhs.pdf"
        ["link"]=>
        string(58) "https://yoda.yale.edu/data-request/2018-3061/coi_-_singhs/"
        ["alt"]=>
        string(0) ""
        ["author"]=>
        string(4) "1363"
        ["description"]=>
        string(0) ""
        ["caption"]=>
        string(0) ""
        ["name"]=>
        string(12) "coi_-_singhs"
        ["status"]=>
        string(7) "inherit"
        ["uploaded_to"]=>
        int(4532)
        ["date"]=>
        string(19) "2023-07-31 15:06:11"
        ["modified"]=>
        string(19) "2023-08-01 01:08:38"
        ["menu_order"]=>
        int(0)
        ["mime_type"]=>
        string(15) "application/pdf"
        ["type"]=>
        string(11) "application"
        ["subtype"]=>
        string(3) "pdf"
        ["icon"]=>
        string(62) "https://yoda.yale.edu/wp/wp-includes/images/media/document.png"
      }
    }
    [2]=>
    array(1) {
      ["file_coi"]=>
      array(21) {
        ["ID"]=>
        int(8699)
        ["id"]=>
        int(8699)
        ["title"]=>
        string(17) "coi_-_proudfootja"
        ["filename"]=>
        string(21) "coi_-_proudfootja.pdf"
        ["filesize"]=>
        int(156345)
        ["url"]=>
        string(70) "https://yoda.yale.edu/wp-content/uploads/2017/07/coi_-_proudfootja.pdf"
        ["link"]=>
        string(63) "https://yoda.yale.edu/data-request/2018-3061/coi_-_proudfootja/"
        ["alt"]=>
        string(0) ""
        ["author"]=>
        string(4) "1363"
        ["description"]=>
        string(0) ""
        ["caption"]=>
        string(0) ""
        ["name"]=>
        string(17) "coi_-_proudfootja"
        ["status"]=>
        string(7) "inherit"
        ["uploaded_to"]=>
        int(4532)
        ["date"]=>
        string(19) "2023-07-31 15:06:06"
        ["modified"]=>
        string(19) "2023-08-01 01:08:38"
        ["menu_order"]=>
        int(0)
        ["mime_type"]=>
        string(15) "application/pdf"
        ["type"]=>
        string(11) "application"
        ["subtype"]=>
        string(3) "pdf"
        ["icon"]=>
        string(62) "https://yoda.yale.edu/wp/wp-includes/images/media/document.png"
      }
    }
  }
  ["data_use_agreement_training"]=>
  bool(true)
  ["certification"]=>
  bool(true)
  ["project_send_email_updates"]=>
  bool(true)
  ["project_status"]=>
  string(9) "concluded"
  ["project_publ_available"]=>
  bool(true)
  ["project_year_access"]=>
  string(4) "2018"
  ["project_rep_publ"]=>
  array(1) {
    [0]=>
    array(1) {
      ["publication_link"]=>
      array(3) {
        ["title"]=>
        string(152) "Project Summary: Development of a Clinical Prediction Tool for Treatment Outcomes in Infliximab-treated Patients with Moderate-Severe Ulcerative Colitis"
        ["url"]=>
        string(88) "https://yoda.yale.edu/sites/default/files/files/Report%20YODA%20Protocol%202018-3061.pdf"
        ["target"]=>
        string(6) "_blank"
      }
    }
  }
  ["project_assoc_data"]=>
  array(1) {
    [0]=>
    string(9) "proj_summ"
  }
  ["project_due_dil_assessment"]=>
  array(21) {
    ["ID"]=>
    int(11297)
    ["id"]=>
    int(11297)
    ["title"]=>
    string(47) "yoda_project_due_diligence_assessment_2018-3061"
    ["filename"]=>
    string(51) "yoda_project_due_diligence_assessment_2018-3061.pdf"
    ["filesize"]=>
    int(201521)
    ["url"]=>
    string(100) "https://yoda.yale.edu/wp-content/uploads/2023/08/yoda_project_due_diligence_assessment_2018-3061.pdf"
    ["link"]=>
    string(93) "https://yoda.yale.edu/data-request/2018-3061/yoda_project_due_diligence_assessment_2018-3061/"
    ["alt"]=>
    string(0) ""
    ["author"]=>
    string(4) "1363"
    ["description"]=>
    string(0) ""
    ["caption"]=>
    string(0) ""
    ["name"]=>
    string(47) "yoda_project_due_diligence_assessment_2018-3061"
    ["status"]=>
    string(7) "inherit"
    ["uploaded_to"]=>
    int(4532)
    ["date"]=>
    string(19) "2023-08-09 17:35:04"
    ["modified"]=>
    string(19) "2023-08-09 19:21:05"
    ["menu_order"]=>
    int(0)
    ["mime_type"]=>
    string(15) "application/pdf"
    ["type"]=>
    string(11) "application"
    ["subtype"]=>
    string(3) "pdf"
    ["icon"]=>
    string(62) "https://yoda.yale.edu/wp/wp-includes/images/media/document.png"
  }
  ["project_title_link"]=>
  array(21) {
    ["ID"]=>
    int(10956)
    ["id"]=>
    int(10956)
    ["title"]=>
    string(42) "yoda_project_protocol_2018-3061_-_18-05-07"
    ["filename"]=>
    string(46) "yoda_project_protocol_2018-3061_-_18-05-07.pdf"
    ["filesize"]=>
    int(23013)
    ["url"]=>
    string(95) "https://yoda.yale.edu/wp-content/uploads/2023/08/yoda_project_protocol_2018-3061_-_18-05-07.pdf"
    ["link"]=>
    string(88) "https://yoda.yale.edu/data-request/2018-3061/yoda_project_protocol_2018-3061_-_18-05-07/"
    ["alt"]=>
    string(0) ""
    ["author"]=>
    string(4) "1363"
    ["description"]=>
    string(0) ""
    ["caption"]=>
    string(0) ""
    ["name"]=>
    string(42) "yoda_project_protocol_2018-3061_-_18-05-07"
    ["status"]=>
    string(7) "inherit"
    ["uploaded_to"]=>
    int(4532)
    ["date"]=>
    string(19) "2023-08-09 17:18:49"
    ["modified"]=>
    string(19) "2023-08-09 19:21:05"
    ["menu_order"]=>
    int(0)
    ["mime_type"]=>
    string(15) "application/pdf"
    ["type"]=>
    string(11) "application"
    ["subtype"]=>
    string(3) "pdf"
    ["icon"]=>
    string(62) "https://yoda.yale.edu/wp/wp-includes/images/media/document.png"
  }
  ["project_review_link"]=>
  array(21) {
    ["ID"]=>
    int(10683)
    ["id"]=>
    int(10683)
    ["title"]=>
    string(36) "yoda_project_review_-_2018-3061_site"
    ["filename"]=>
    string(40) "yoda_project_review_-_2018-3061_site.pdf"
    ["filesize"]=>
    int(958913)
    ["url"]=>
    string(89) "https://yoda.yale.edu/wp-content/uploads/2023/08/yoda_project_review_-_2018-3061_site.pdf"
    ["link"]=>
    string(82) "https://yoda.yale.edu/data-request/2018-3061/yoda_project_review_-_2018-3061_site/"
    ["alt"]=>
    string(0) ""
    ["author"]=>
    string(4) "1363"
    ["description"]=>
    string(0) ""
    ["caption"]=>
    string(0) ""
    ["name"]=>
    string(36) "yoda_project_review_-_2018-3061_site"
    ["status"]=>
    string(7) "inherit"
    ["uploaded_to"]=>
    int(4532)
    ["date"]=>
    string(19) "2023-08-09 17:07:29"
    ["modified"]=>
    string(19) "2023-08-09 19:21:05"
    ["menu_order"]=>
    int(0)
    ["mime_type"]=>
    string(15) "application/pdf"
    ["type"]=>
    string(11) "application"
    ["subtype"]=>
    string(3) "pdf"
    ["icon"]=>
    string(62) "https://yoda.yale.edu/wp/wp-includes/images/media/document.png"
  }
  ["project_highlight_button"]=>
  string(0) ""
  ["request_data_partner"]=>
  string(15) "johnson-johnson"
  ["search_order"]=>
  string(5) "-9070"
  ["request_overridden_res"]=>
  string(1) "2"
}
data partner
array(1) {
  [0]=>
  string(15) "johnson-johnson"
}


pi country
array(1) {
  [0]=>
  string(13) "United States"
}


pi affil
array(1) {
  [0]=>
  string(8) "Academia"
}


products
array(1) {
  [0]=>
  string(8) "remicade"
}


num of trials
array(1) {
  [0]=>
  string(1) "3"
}


res
array(1) {
  [0]=>
  string(1) "2"
}