Home - The YODA Project

The right to search for truth implies also a duty; one must not conceal any part of what one has recognized to be true.

Albert Einstein

Our Mission

The Yale University Open Data Access (YODA) Project’s mission is to advocate for the responsible sharing of clinical research data, open science, and research transparency. The Project is committed to supporting research focused on improving the health of patients and informing science and public health. The YODA Project can only improve with your feedback. Please share your comments and ideas.

Our Model

The YODA Project seeks mutually beneficial partnerships with Data Partners, promoting independence, responsible conduct of research, good stewardship of data, and the generation of knowledge in the best interest of society. To participate, each Data Partner must transfer full jurisdiction over data access to the YODA Project.

How it works

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Are you ready to request data? To date, 470 trials have been identified as available. The YODA Project and Data Partners continue to identify and add more.

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156 Publications!

Featured Articles

Articles making use of data shared through the YODA Project. Scroll through featured articles below or learn more about approved data requests.

*156 publications from 130 research projects.

View All Featured Articles.

Outcomes of patients with prior biologic intolerance are better than those with biologic failure in clinical trials of inflammatory bowel disease

Samnani S, Wong ECL, Hamam H, Dulai PS, Marshall JK, Jairath V, Reinisch W, Narula N. Outcomes of patients with prior biologic intolerance are better than those with biologic failure in clinical trials of inflammatory bowel disease. J Crohns Colitis. 2024 Sep 20:jjae151. doi: 10.1093/ecco-jcc/jjae151. Epub ahead of print. PMID: 39302135.
No Impact of Concomitant Medications on Efficacy and Safety of Biologics and Small Molecules for Ulcerative Colitis

Ahuja D, Zou G, Solitano V, Syal G, Lee HH, Ma C, Jairath V, Singh S. No Impact of Concomitant Medications on Efficacy and Safety of Biologics and Small Molecules for Ulcerative Colitis. Clin Gastroenterol Hepatol. 2024 Oct 10:S1542-3565(24)00877-2. doi: 10.1016/j.cgh.2024.08.040. Epub ahead of print. PMID: 39395572.
Examining the Effect of Missing Data and Unmeasured Confounding on External Comparator Studies: Case Studies and Simulations

Rippin G, Sanz H, Hoogendoorn WE, Ballarini NM, Largent JA, Demas E, Postmus D, Framke T, Dávila LMA, Quinten C, Pignatti F. Examining the Effect of Missing Data and Unmeasured Confounding on External Comparator Studies: Case Studies and Simulations. Drug Saf. 2024 Aug 5. doi: 10.1007/s40264-024-01467-9. Epub ahead of print. PMID: 39102176.
Pooling Alzheimer’s disease clinical trial data to develop personalized medicine approaches is easier said than done: A proof-of-principle study and call to action

Dubbelman MA, Vromen EM, Tijms BM, Berkhof J, Ottenhoff L, Vijverberg EGB, Prins ND, van der Flier WM, Sikkes SAM. Pooling Alzheimer’s disease clinical trial data to develop personalized medicine approaches is easier said than done: A proof-of-principle study and call to action. Alzheimers Dement (N Y). 2024 Aug 7;10(3):e12485. doi: 10.1002/trc2.12485. PMID: 39114370; PMCID: PMC11303826.
Demonstration of Group-Level and Individual-Level Efficacy Using Time-to-Event Designs for Clinical Trials of Antiseizure Medications

Kerr WT, Kok N, Reddy AS, McFarlane KN, Stern JM, Pennell PB, Stacey W, French J. Demonstration of Group-Level and Individual-Level Efficacy Using Time-to-Event Designs for Clinical Trials of Antiseizure Medications. Neurology. 2024 Aug 27;103(4):e209713. doi: 10.1212/WNL.0000000000209713. Epub 2024 Jul 25. PMID: 39052963; PMCID: PMC11271390.
Assessing trial representativeness using serious adverse events: an observational analysis using aggregate and individual-level data from clinical trials and routine healthcare data

Hanlon P, Butterly E, Shah ASV, Hannigan LJ, Wild SH, Guthrie B, Mair FS, Dias S, Welton NJ, McAllister DA. Assessing trial representativeness using serious adverse events: an observational analysis using aggregate and individual-level data from clinical trials and routine healthcare data. BMC Med. 2022 Oct 28;20(1):410. doi: 10.1186/s12916-022-02594-9. PMID: 36303169; PMCID: PMC9615407.
Higher Postinduction Infliximab Concentrations Are Associated With Favorable Clinical Outcomes in Pediatric Crohn’s Disease: A Post Hoc Analysis of the REACH Trial

Cheifetz AS, Vande Casteele N, Wang Z, Dubinsky MC, Papamichael K. Higher Postinduction Infliximab Concentrations Are Associated With Favorable Clinical Outcomes in Pediatric Crohn’s Disease: A Post Hoc Analysis of the REACH Trial. Am J Gastroenterol. 2023 Mar 1;118(3):485-490. doi: 10.14309/ajg.0000000000002096. Epub 2022 Dec 23. PMID: 36624036; PMCID: PMC9991960.
Modeling First-Line Daratumumab Use for Newly Diagnosed, Transplant-Ineligible, Multiple Myeloma: A Cost-Effectiveness and Risk Analysis for Healthcare Payers

Bayani DB, Lin YC, Nagarajan C, Ooi MG, Tso ACY, Cairns J, Wee HL. Modeling First-Line Daratumumab Use for Newly Diagnosed, Transplant-Ineligible, Multiple Myeloma: A Cost-Effectiveness and Risk Analysis for Healthcare Payers. Pharmacoecon Open. 2024 Sep;8(5):651-664. doi: 10.1007/s41669-024-00503-9. Epub 2024 Jun 20. PMID: 38900407; PMCID: PMC11362436.
Differential efficacy of medical therapies for ulcerative colitis according to disease extent: patient-level analysis from multiple randomized controlled trials

Vuyyuru SK, Ma C, Nguyen TM, Zou G, Peyrin-Biroulet L, Danese S, Dulai P, Narula N, Singh S, Jairath V. Differential efficacy of medical therapies for ulcerative colitis according to disease extent: patient-level analysis from multiple randomized controlled trials. EClinicalMedicine. 2024 May 4;72:102621. doi: 10.1016/j.eclinm.2024.102621. PMID: 38726222; PMCID: PMC11079462.
Characterizing Treatment Non-responders vs. Responders in Completed Alzheimer’s Disease Clinical Trials

Wang D, Ling Y, Harris K, Schulz PE, Jiang X, Kim Y. Characterizing Treatment Non-responders vs. Responders in Completed Alzheimer’s Disease Clinical Trials. medRxiv [Preprint]. 2023 Oct 30:2023.10.27.23297685. doi: 10.1101/2023.10.27.23297685. PMID: 37961216; PMCID: PMC10635230.