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  string(122) "Incidence of visceral metastasis at time of progression on abiraterone for metastatic castration-resistant prostate cancer"
  ["project_narrative_summary"]=>
  string(700) "Treatments for prostate cancer can be effective whether patients have metastatic disease in bones, lymph nodes, or organs (lung or liver). However, the prognosis is poor for patients with organ metastases at the start of treatment. It is not known whether the location of metastases is changed after therapy for medications like abiraterone. Some patients may develop more aggressive disease after treatment. We will determine if organ metastases are increased at the time of progression by comparing the sites/sizes of metastasis before and after therapy. The data from this project is important to future studies, in particularly as these medicines are being trialed in early in the disease course."
  ["project_learn_source"]=>
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      ["p_pers_f_name"]=>
      string(6) "Samuel"
      ["p_pers_l_name"]=>
      string(8) "Denmeade"
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      string(2) "MD"
      ["p_pers_pr_affil"]=>
      string(24) "Johns Hopkins University"
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      string(4) "Fang"
      ["p_pers_l_name"]=>
      string(3) "Qui"
      ["p_pers_degree"]=>
      string(2) "MS"
      ["p_pers_pr_affil"]=>
      string(37) "University of Nebraska Medical Center"
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    ["value"]=>
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    ["label"]=>
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      string(233) "NCT00638690 - A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Abiraterone Acetate (CB7630) Plus Prednisone in Patients With Metastatic Castration-Resistant Prostate Cancer Who Have Failed Docetaxel-Based Chemotherapy"
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      string(223) "NCT00887198 - A Phase 3, Randomized, Double-blind, Placebo-Controlled Study of Abiraterone Acetate (CB7630) Plus Prednisone in Asymptomatic or Mildly Symptomatic Patients With Metastatic Castration-Resistant Prostate Cancer"
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  ["project_date_type"]=>
  string(91) "Individual Participant-Level Data, which includes Full CSR and all supporting documentation"
  ["property_scientific_abstract"]=>
  string(1623) "Background: Abiraterone is a life-prolonging treatment for patients with metastatic castration-resistant prostate cancer (CRPC), yet at the time of progression the tumors are often rendered clinically resistant to further androgen-directed therapy. In some patients, these tumors may be driven to an aggressive phenotype, in-part characterized by the development of visceral metastatic disease. We hypothesize that visceral metastases are increased at the time of progression on abiraterone.

Objective: Our primary objective is to estimate the incidence of visceral metastatic disease at the time of progression on abiraterone. Secondary objectives include comparing incidence of visceral metastatic disease between subjects treated with abiraterone or placebo, calculate visceral metastasis-free survival, and identify factors associated with development of visceral metastatic disease.

Study Design: We will analyze the distribution of metastatic disease for subjects who participated in the COU-AA-301, comparing baseline distributions to distribution at time of progression for cohorts of patients treated with abiraterone and placebo.

Participants: Our analysis will include all subjects available in the dataset from COU-AA-301.

Main Outcome Measure: The primary endpoint is incidence of visceral metastatic disease, calculated by analysis of disease distribution at baseline versus at time of progression.

Statistical Analysis: The primary endpoint will be analyzed by comparing pre- and post-treatment proportions of site-specific metastasis using McNemar?s test of paired proportions."
  ["project_brief_bg"]=>
  string(2832) "Abiraterone is a life-prolonging treatment for patients with metastatic castration-resistant prostate cancer (CRPC), yet the potent antiandrogen activity of the drug often yields tumors that are clinically resistant to further androgen-directed therapy at the time of progression [1]. Anecdotally, we have observed more clinically aggressive CRPC upon progression on abiraterone in some patients, including the development of life-threatening liver metastases. In this study, we are analyzing differences in the distribution of metastatic disease at the time of initiation and progression on abiraterone, with a particular interest in whether visceral metastatic disease is increased.

The distribution of sites of metastatic disease is important for CRPC because the pattern of disease influences survival [2].  For example, in analyses of patients treated with chemotherapy, patients with node-only disease have superior survival to those with bone disease or visceral disease.  Liver metastatic disease portends the worst prognosis [3, 4]. The negative prognostic implications of visceral metastases have been confirmed in meta-analyses of patients treated with chemotherapy or hormonal therapy [5]. 

There are currently no published data describing the change disease distribution at the time of radiographic progression on novel hormonal agents (including abiraterone) or cabazitaxel. Chemotherapy with docetaxel has been previously reported to not change the distribution of metastatic disease?namely, patients with bone disease progress in bone, patients with nodal disease progress in nodes, and patients with visceral disease progress in those viscera [6]. However, given the unique mechanism of action of abiraterone, it is possible that disease distribution is significantly altered after exposure to abiraterone and similar agents.

Based upon this understanding of abiraterone?s mechanism of action and our clinical observations, we hypothesize that visceral metastases are increased at the time of radiographic disease progression on abiraterone compared to baseline.  In order to test this hypothesis, we will study the patterns of metastatic disease progression after treatment with abiraterone. We also aim to compare the change in metastatic disease distribution at progression for abiraterone for patients treated with placebo (prednisone alone) as well as to a parallel analysis of patients treated with cabazitaxel, to determine if similar changes are seen in all cohorts. This work is significant, in-part, as potent novel hormonal agents are now frequently used in the first-line for CRPC, and trials are testing these agents earlier in the course of the disease.  Yet, these agents may be fundamentally changing the overall disease course and inducing early visceral disease in some patients."
  ["project_specific_aims"]=>
  string(806) "We hypothesize that visceral metastases are increased at time of progression on abiraterone compared to baseline.

Primary specific aim / objective:

1. To estimate the incidence of visceral metastasis at time of radiographic progression on abiraterone.

Secondary specific aims / objectives:

1. To estimate the visceral metastasis-free survival for patients treated with abiraterone.

2. To determine clinical factors associated with the development of visceral metastatic disease.

3. To associate overall survival with disease distribution at baseline in comparison to at radiographic progression.

4. To compare incidence of new visceral metastatic disease at progression and visceral metastasis-free survival in patients treated with abiraterone or placebo therapy."
  ["project_study_design"]=>
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  ["project_purposes"]=>
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    [0]=>
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      ["value"]=>
      string(114) "New research question to examine treatment effectiveness on secondary endpoints and/or within subgroup populations"
      ["label"]=>
      string(114) "New research question to examine treatment effectiveness on secondary endpoints and/or within subgroup populations"
    }
    [1]=>
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      ["value"]=>
      string(49) "New research question to examine treatment safety"
      ["label"]=>
      string(49) "New research question to examine treatment safety"
    }
  }
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  ["project_research_methods"]=>
  string(1218) "We will employ a post-hoc analysis of the COU-AA-301 data to compare the distribution of metastatic disease at study entry versus at the time of radiographic progression.  Our primary endpoint is the presence of visceral metastatic disease at the time of progression on abiraterone in order to estimate the incidence of visceral metastatic disease.  

All patients treated on the COU-AA-301 trial will be eligible for this analysis.  Requested Data:

Demographic information

-Age

-Race

-Gleason Score

-Date of Diagnosis

-Prior anti-cancer therapies

-Prior prostatectomy and/or radiation therapy

-Investigations (PSA, Hgb, Cr, AlkPhos, LDH)

-Pain score

-Performance Status

-Cohort

-#cycles

-Mode of progression

-Best PSA response

-Date of initiation

-Date of PSA progression (PSA progression-free survival)

-Date of Radiographic PFS (Radiographic progression-free survival)

-Date of death (overall survival)

-CT and NM Bone scan description of metastatic disease at baselin (# bone, nodal, visceral)

-CT and NM Bone scan description of metastatic disease at progression (# bone, nodal, visceral)"
  ["project_main_outcome_measure"]=>
  string(609) "The primary endpoint is the incidence of visceral metastatic disease at the time of disease progression.  Thus, the main outcome measure will be the distribution of metastatic disease at the time of progression, broken down by location and number of metastases, with a comparison by RECIST criteria to determine if lesions are new/progressed.  This outcome will be calculated for patients regardless of reason for study therapy completion (toxicity, clinical progression or radiographic progression).  The data regarding the CT and NM bone scans at initiation and progression will be utilized for the measure."
  ["project_main_predictor_indep"]=>
  string(131) "The primary independent variable will be assigned study treatment (abiraterone versus placebo).  It is assigned per study protocol."
  ["project_other_variables_interest"]=>
  string(1253) "Age at study entry (years)

Race (Am. Indian, Asian, Black , Native Hawaiian or Other Pacific Islander, White)

Gleason Score (sum)

Date of Diagnosis

Prior anti-cancer therapies (number of prior hormonal therapies, prior ketoconazole, prior chemotherapies)

Prior prostatectomy and/or radiation therapy (Y/N for each)

Investigations (PSA, Hgb, Cr, AlkPhos, LDH)

Pain score / presence of pain (binary Y/N)

Performance Status (ECOG)

Cohort (Abiraterone or Placebo)

# cycles administered / duration of exposure to agent (in # of cycles)

Mode of progression (clinical, radiographic, toxicity)

Best PSA response (% reduction)

Date of Abiraterone or Prednisone initiation

Date of PSA progression (PSA progression-free survival)

Date of Radiographic PFS (Radiographic progression-free survival)

Number of bone mets at baseline

Number of nodal mets at baseline

Number of visceral mets (liver, lung, other) at baseline

Number of bone mets at progression ? and if progression in bone

Number of nodal mets at progression ? and if progression in node

Number of visceral mets (liver, lung, other) at progression ? and if progression in viscera"
  ["project_stat_analysis_plan"]=>
  string(522) "Disease characteristics will be compared using descriptive statistics and t-tests. Pre- and post-treatment proportions of site-specific metastases will be compared using McNemar?s test of paired proportions.  Multivariate analyses will be performed to determine if other clinical characteristics or factors are associated with development of visceral metastatic disease.  Kaplan-Meier analyses will be used to compare the time-to-event endpoints.  Interaction tests will be used to compare the differences between cohorts."
  ["project_timeline"]=>
  string(144) "Project start date: 9/2016

Analysis completion date: 11/2016

Date manuscript drafted/submitted: 2/2017

Results reported 5/2017"
  ["project_dissemination_plan"]=>
  string(129) "Anticipate presentation of data at GU ASCO 2017 or ASCO 2017, with manuscript publication in European Urology or similar journal."
  ["project_bibliography"]=>
  string(1290) "
1.	Azad AA, Eigl BJ, Murray RN, et al. Efficacy of enzalutamide following abiraterone acetate in chemotherapy-naive metastatic castration-resistant prostate cancer patients. European urology. 2015;67(1):23-9.

2.	Pond GR, Sonpavde G, de Wit R, et al. The prognostic importance of metastatic site in men with metastatic castration-resistant prostate cancer. European urology. 2014;65(1):3-6.

3.	Goodman OB, Jr., Flaig TW, Molina A, et al. Exploratory analysis of the visceral disease subgroup in a phase III study of abiraterone acetate in metastatic castration-resistant prostate cancer. Prostate cancer and prostatic diseases. 2014;17(1):34-9.

4.	Evans CP, Higano CS, Keane T, et al. The PREVAIL Study: Primary Outcomes by Site and Extent of Baseline Disease for Enzalutamide-treated Men with Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer. European urology. 2016.

5.	Halabi S, Kelly WK, Ma H, et al. Meta-Analysis Evaluating the Impact of Site of Metastasis on Overall Survival in Men With Castration-Resistant Prostate Cancer. J Clin Oncol. 2016;34(14):1652-U191.

6.	Sella A, Sternberg C, Kovel S, et al. Progression after docetaxel-based chemotherapy in androgen-independent prostate cancer. BJU international. 2007;100(3):533-5.
"
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data partner
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pi country
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pi affil
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products
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}


num of trials
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res
array(1) {
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}