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  string(1610) "Background & Rationale: Ustekinumab (UST) is a monoclonal antibody that targets the standard p40 subunit of the cytokines IL-12/23 and has been shown to be effective in inducing and maintaining clinical remission in moderate-severe CD (6,7,8). UST has shown to have clinical efficacy in treatment of psoriatic arthritis (1-3). However, there are no studies that have assessed the effectiveness of in CD in remission of arthritis and arthralgia.

Objective: This post hoc analysis aims to evaluate the efficacy of UST in treatment of arthritis and arthralgia in moderate-severe CD patients.

Study Design: UNITI-1/ 2 trials were multi-centre, double blinded, placebo-controlled trials that randomized patients to ustekinumab or placebo. The induction trials were 8 weeks, which were followed by the 44-week IM-UNITI trial for patients who had an initial response. We will be conducting a post-hoc analysis.

Participants: Adult patients with moderate-to-severe CD [defined as a Crohn?s Disease Activity Index (CDAI) score 220-450) who were eligible for UNITI-1 and UNITI-2.

Main Outcome Measure(s): The presence (scored 20 on CDAI) or absence (scored 0 on CDAI) of arthritis/arthralgia, measured at baseline, weeks 3, 6, 8 and 44. The secondary outcomes will evaluate the presence (scored 20 on CDAI) or absence (scored 0 on CDAI) of other extra-intestinal manifestations.

Statistical Analysis: Univariate and multivariate regression analyses will be performed to assess for the association of arthritis/arthralgia and efficacy outcomes of clinical remission and mucosal healing."
  ["project_brief_bg"]=>
  string(833) "Ustekinumab (UST) is a monoclonal antibody that targets the standard p40 subunit of the cytokines IL-12 and IL-23 (IL12/23p40), which are involved in the pathogenesis of Crohn?s disease (CD) . UST was shown to be effective in inducing and maintaining clinical remission in CD patients with moderate to severe CD (6,7,8). UST has produced consistent and clinical efficacy in treatment of psoriatic arthritis (1-3). However, to our knowledge, there are no studies that have assessed the effectiveness of in CD in remission of extra-intestinal manifestations, specifically arthritis and arthralgia. This has clinical implications in moderate-severe CD as it establishes what characteristics of disease activity (extent, severity, mucosal healing) are correlated or associated with the presence of extra-intestinal manifestations of IBD."
  ["project_specific_aims"]=>
  string(779) "This post hoc analysis of moderate-severe CD patients from UNITI-1 (ClinicalTrial.gov number: NCT01369329), UNITI-2 (ClinicalTrial.gov number: NCT01369342), and IM-UNITI (ClinicalTrial.gov number: NCT01369355) aim  to evaluate the efficacy of UST in treatment of arthritis and arthralgia in moderate-severe CD. 

Our hypothesis is that UST is effective in remission of baseline arthritis or arthralgia in patients with moderate-severe CD.  The effectiveness of UST to induce remission and maintain the absence of arthritis/arthralgia and other extra-intesitnal manifestations (iritis, uveitis, erythema nodosum, pyoderma gangrenosum, apthous stomatitis, anal fissure/fistula/abscess, other fistula, and fever over 100F (37.8C) during the previous 7 days will be performed)."
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  ["project_research_methods"]=>
  string(1179) "The study will utilize data from the Yale University Open Data Access (YODA) Project. Participant-level data will be required for the following trials: UNITI-1 (ClinicalTrial.gov number: NCT01369329), UNITI-2 (ClinicalTrial.gov number: NCT01369342), and IM-UNITI (ClinicalTrial.gov number: NCT01369355).  UNITI-1 and UNITI-2 were two multicentre, double-blinded, placebo-controlled trials that randomized patients to UST or placebo in CD. These induction trials were 8 weeks in duration and were followed with a 44-week follow-up period in the IM-UNITI trial for patients who had an initial response. Inclusion Criteria were as follows: (a) ?18 years of age, (b) CD for a minimum duration of 3 months, (c) Moderate-to-severe CD (defined as a CDAI 220-450), (d) Nonresponse to anti-TNF therapy, treatment failure to immunomodulators and/or glucocorticoids, (3) Participants from UNITI-1/2 with an initial response and those in IM-UNITI. The exclusion criteria were as follows: (a) Bowel resection within 6 months, (b) Infliximab, adalimumab or certolizumab pegol ?8 weeks before receiving study drug, (c) Ongoing chronic/recurrent infectious disease, (d) Prior IL-12/23 antagonist"
  ["project_main_outcome_measure"]=>
  string(360) "The CDAI is a tool consisting of eight variables used to assess the quality of life of patients with CD, and was the primary measurement of disease activity response to UST (5). UNITI defined clinical response as a decrease in CDAI score of ?100 points from week 0 of induction or clinical remission. Furthermore, clinical remission was defined as a CDAI score"
  ["project_main_predictor_indep"]=>
  string(305) "CD disease activity will be the main predictor, which will be measured with CRP levels (measured at weeks 0, 3,  and 8 during induction and at 4-weeks intervals during maintenance) , and fecal calprotectin levels (measured at weeks 0 and 6 during induction, and at weeks 8, 24, and 44 during maintenance)."
  ["project_other_variables_interest"]=>
  string(332) "The evaluation for the presence (scored 20 on CDAI) or absence (scored 0 on CDAI) of other extra-intestinal manifestations of CD such as iritis, uveitis, erythema nodosum, pyoderma gangrenosum, apthous stomatitis, anal fissure/fistula/abscess, other fistula, and fever over 100F (37.8C) during the previous 7 days will be performed."
  ["project_stat_analysis_plan"]=>
  string(1216) "Descriptive statistics will be used to summarize baseline demographics and disease characteristics of CD patients. Continuous variables will be presented as means (and standard deviations [SD] or as medians and interquartile ranges [IQR] if the distribution is skewed). Categorical or binary variables will be presented as proportions or percentages. Univariate and multivariate regression analyses will be performed to assess for the association of the presence of arthritis/arthralgia and efficacy outcomes of clinical remission, clinical response and mucosal healing in UNITI-1/2 and IM-UNITI. 

Approved investigators will be granted access to participant-level data sets provided by the YODA project via a remote, secure, password-protected data sharing platform. All work on the data will take place within the secure platform. Analyses with data provided by the YODA project will be conducted using the software available on the remote platform. The platform will be easily accessible to researchers, and ongoing system monitoring and support will be available. If needed, researchers will be able to upload additional data sets to the secure platform, if the researcher has the rights/license to do so."
  ["project_timeline"]=>
  string(546) "Anticipated Project Start Date: To be started within the first week of database approval and acquisition in January 2020.

Analysis Completion Date: Research proposal to be finalized with data collection and analysis. Estimated data of completion will be March 2020.

Manuscript Draft Date: Manuscript draft estimated to be completed in April 2020.

Manuscript Submission Date: April 2020 ? May 2020.

Any manuscripts, abstracts, posters, presentations, etc. will be shared with the YODA Project at the time of submission."
  ["project_dissemination_plan"]=>
  string(891) "Anticipated products include abstracts, which will be published or shared during scientific meetings, including Canadian Digestive Diseases Week, Digestive Disease Week, and European Crohn?s and Colitis Organisation. Additionally, a manuscript is expected to be completed for the research project and will be submitted for publication to relevant peer-reviewed journals. Potential journals for submission include Clinical Gastroenterology and Hepatology, Journal of Crohn?s and Colitis, Inflammatory Bowel Diseases, and Digestive Diseases and Sciences. The dissemination of results, which may include but are not limited to abstracts, manuscripts, preprints, posters, and slide decks will be shared with the YODA Project at the time of submission. Target audiences include clinicians and researchers interested in the advancement of the inflammatory bowel disease diagnostics and management."
  ["project_bibliography"]=>
  string(1481) "
1. Gottlieb A, Menter A, Mendelsohn A, Shen Y-K, Li S, Guzzo C, et al. Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial. Lancet. 2009;373(9664):633-40.

2. McInnes IB, Kavanaugh A, Gottlieb AB, Puig L, Rahman P, Ritchlin C, et al. Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial. Lancet. 2013;382(9894):780-9.

3. Ritchlin C, Rahman P, Kavanaugh A, McInnes IB, Puig L, Li S, et al. Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional non-biological and biological anti-tumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial. Ann Rheum Dis. 2014;73(6):990-9.

4. Feagan BG, Sandborn WJ, Gasink C, Jacobstein D, Lang Y, Friedman JR, et al. Ustekinumab as Induction and Maintenance Therapy for Crohn’s Disease. N Engl J Med. 2016;375(20):1946-60.

5. Irvine EJ, Feagan B, Rochon J, Archambault A, Fedorak RN, Groll A, et al. Quality of life: a valid and reliable measure of therapeutic efficacy in the treatment of inflammatory bowel disease. Canadian Crohn’s Relapse Prevention Trial Study Group. Gastroenterology. 1994;106(2):287-96.
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