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  string(87) "Validation of a shortened PANSS for use in clinical trials of adolescent schizophrenia."
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  string(690) "The 30 item PANSS scale is the gold standard efficacy measure in adult schizophrenia trials. Because of a lack of validated measures in youth, it has also been used in adolescent schizophrenia trials. The scale is long and burdensome for adolescents and their parents. There have been statistical attempts to reduce the number of items to reduce burden in adult trials. Our group is exploring a reduced item scale for use with adolescents. We have looked at an NIMH dataset that did not have a placebo control. We would like to examine the data sets requested to determine the fit with our initial findings and to see if the reduced item PANSS will show discrimination of drug from placebo."
  ["project_learn_source"]=>
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  string(101) "Research designed to explore feasibility of shortened PANSS (efficacy scale) for use with adolescents"
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      string(7) "Langfus"
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      string(13) "MA / MS / MSc"
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  ["project_date_type"]=>
  string(91) "Individual Participant-Level Data, which includes Full CSR and all supporting documentation"
  ["property_scientific_abstract"]=>
  string(1600) "Background: The 30 item PANSS scale is the gold standard efficacy measure in adult schizophrenia trials. Because of a lack of validated measures in youth, it has also been used in adolescent schizophrenia trials. The scale is difficult to administer and burdensome for adolescents and their parents. There have been statistical attempts to reduce the number of items to reduce burden in adult trials. Our group is exploring 2 reduced item scales for use with youth. We have looked at an NIMH dataset that did not have a placebo control. We would like to examine the paliperidone data sets requested to determine if our preliminary findings hold up and to see if the reduced item PANSS would show discrimination of drug from placebo. Objective: The goal of the project is to develop and validate a short form of the PANSS. Design: Psychometric analyses. Participants: All randomized subjects. Main Outcome Measures: PANSS individual items, CGI-S/I by treatment and visit. Statistical Analysis: PANSS item data will be used in psychometric analyses (factor analysis, item response theory analysis) to examine item functioning and develop a candidate short form. Following the methods implemented in our previous development of short forms we will evaluate factor structure, item characteristics, internal consistency, and convergent and  discriminant validity (using  clinical and demographic characteristics and CGI-S/CGI-I scores as criteria). The PANSS item data from follow-up visits will be used to evaluate retest stability of the short form (in the placebo arm) as well as treatment sensitivity."
  ["project_brief_bg"]=>
  string(673) "The 30 item PANSS is a long and burdensome scale, even in the adult patients for whom it was designed.  For children and adolescents the scale is well known to pose a challenge for the patients, the parents, and the clinicians and researchers administering it.  The research and clinical field would be advanced by a shortened scale that retained the ability to assess severity and treatment changes over time.  Our group is comprised of  leaders in adolescent psychopharmacology trials, application of the PANSS to adolescents in clinical trials, and item analysis statistics.   A brief listing of relevant publications is provided at the end of the proposal as requested."
  ["project_specific_aims"]=>
  string(1232) "The goal of the project is to develop and validate a short form of the Positive and Negative Symptoms Scale, a widely used interview to assess psychotic symptoms. The PANSS was designed for adults not children, and takes a substantial amount of interview time. A short form that concentrated on the most helpful items would reduce burden for participants, as well as training and administration costs for researchers. A short form also would be helpful in clinical applications.  The data needed for the project will be the PANSS items at baseline and each study visit, as well as treatment assignment, demographic and clinical characteristics including comorbid diagnoses, and CGI-S/I scores.  PANSS item data will be used in psychometric analyses (factor analysis, item response theory analysis) to examine item functioning and develop a candidate short form. We will evaluate factor structure, item characteristics, internal consistency, convergent and discriminant validity (using the comorbid diagnoses, clinical and demographic characteristics, and CGI scores as criteria). PANSS item data from follow-up visits will be used to evaluate retest stability of the short form (in the placebo arm) as well as treatment sensitivity."
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      ["label"]=>
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      ["label"]=>
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    }
    [2]=>
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      ["label"]=>
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  string(193) "All randomized subjects from the two requested paliperidone trials.  All randomized subjects from the NIMH TEOSS study (Treatment  of Early Onset Schizophrenia Spectrum Disorders) -- NDA #2143."
  ["project_main_outcome_measure"]=>
  string(28) "individual item PANSS scores"
  ["project_main_predictor_indep"]=>
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  ["project_other_variables_interest"]=>
  string(103) "Age at baseline, comorbid diagnoses at baseline, CGI-S at each visit, CGI-I at all post-baseline visits"
  ["project_stat_analysis_plan"]=>
  string(773) "PANSS item data will be used in psychometric analyses (factor analysis, item response theory analysis) to examine item functioning and develop and assess candidate short forms. We will evaluate factor structure, item characteristics, internal consistency, convergent and discriminant validity (using the comorbid diagnoses, clinical and demographic characteristics, and CGI scores as criteria). PANSS item data from follow-up visits will be used to evaluate retest stability of the short form (in the placebo arm) as well as treatment sensitivity.  2 candidate forms we developed in earlier analyses of a non-placebo-controlled adolescent schizophrenia NIMH data set will be examined for fit with data from the placebo-controlled paliperidone data we are herein requesting."
  ["project_timeline"]=>
  string(548) "12 months should be sufficient for us to access, analyze, and present results for presentation at scientific conferences.  A manuscript draft ready for submission should be available within this timeframe as well.

Our specific plan is to complete the bulk of the data analysis in time for a June, 2021 submission to AACAP (for presentation in October); additional data analyses would be done by August, 2021, in time for submission to ACNP (for presentation, December, 2021).  We plan to  have a manuscript submitted by end of December, 2021."
  ["project_dissemination_plan"]=>
  string(421) "We plan to disseminate the findings at scientific conferences of relevance to the  child psychopharmacology field such as ASCP, APA, AACAP and ACNP.  We plan to generate manuscripts for publication in journals of relevance to clinicians and researchers in childhood psychosis and  psychopharmacology.   Preliminary findings from our NIMH dataset were presented this year at ASCP and will be presented in December at ACNP."
  ["project_bibliography"]=>
  string(1932) "
Busner, J., Youngstrom, E.A., Daniel, D.G., Findling, R.L. Toward development of an abbreviated PANSS for pediatric trials: New analyses of PANSS TEOSS data. Accepted for presentation at the American College of Neuropsychopharmacology Annual Meeting, Dec. 5., 2020.

Busner, J., Youngstrom, E.A., Daniel, D.G., Findling, R.L. Toward development of an abbreviated PANSS for pediatric trials: Secondary analyses of TEOSS and other psychopharmacologic data sets.  Presented as poster at the American Society of Clinical Psychopharmacology (ASCP), formerly NCDEU, Annual Meeting, Miami, FL., May 25-29, 2020

Salcedo, S., Rizvi, S. H., Freeman, L. K., Youngstrom, J. K., Findling, R. L., & Youngstrom, E.

A. (2018). Diagnostic efficiency of the CBCL thought problems and DSM-oriented psychotic

symptoms scales for pediatric psychotic symptoms. Eur Child Adolesc Psychiatry.

https://doi.org/10.1007/s00787-018-1140-1

Youngstrom, E. A., Frazier, T. W., Findling, R. L., & Calabrese, J. R. (2008). Developing a ten

item short form of the Parent General Behavior Inventory to assess for juvenile mania and

hypomania. Journal of Clinical Psychiatry, 69, 831-839. https://doi.org/10.4088/JCP.v69n0517

Youngstrom, E. A., Murray, G., Johnson, S. L., & Findling, R. L. (2013). The 7 Up 7 Down

Inventory: A 14-item measure of manic and depressive tendencies carved from the General

Behavior Inventory. Psychological Assessment, 25, 1377-1383. https://doi.org/10.1037/a0033975

Youngstrom, E. A., Van Meter, A. R., Frazier, T. W., Youngstrom, J. K., & Findling, R. L.

(2018). Developing and validating short forms of the Parent General Behavior Inventory Mania

and Depression Scales for rating youth mood symptoms. Journal of Clinical Child & Adolescent

Psychology. https://doi.org/https://doi.org/10.1080/15374416.2018.1491006
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    string(19) "2023-08-09 19:16:02"
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    ["mime_type"]=>
    string(15) "application/pdf"
    ["type"]=>
    string(11) "application"
    ["subtype"]=>
    string(3) "pdf"
    ["icon"]=>
    string(62) "https://yoda.yale.edu/wp/wp-includes/images/media/document.png"
  }
  ["project_review_link"]=>
  array(21) {
    ["ID"]=>
    int(10634)
    ["id"]=>
    int(10634)
    ["title"]=>
    string(36) "yoda_project_review_-_2020-4528_site"
    ["filename"]=>
    string(40) "yoda_project_review_-_2020-4528_site.pdf"
    ["filesize"]=>
    int(1313805)
    ["url"]=>
    string(89) "https://yoda.yale.edu/wp-content/uploads/2023/08/yoda_project_review_-_2020-4528_site.pdf"
    ["link"]=>
    string(82) "https://yoda.yale.edu/data-request/2020-4528/yoda_project_review_-_2020-4528_site/"
    ["alt"]=>
    string(0) ""
    ["author"]=>
    string(4) "1363"
    ["description"]=>
    string(0) ""
    ["caption"]=>
    string(0) ""
    ["name"]=>
    string(36) "yoda_project_review_-_2020-4528_site"
    ["status"]=>
    string(7) "inherit"
    ["uploaded_to"]=>
    int(5188)
    ["date"]=>
    string(19) "2023-08-09 17:05:26"
    ["modified"]=>
    string(19) "2023-08-09 19:16:02"
    ["menu_order"]=>
    int(0)
    ["mime_type"]=>
    string(15) "application/pdf"
    ["type"]=>
    string(11) "application"
    ["subtype"]=>
    string(3) "pdf"
    ["icon"]=>
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  }
  ["project_highlight_button"]=>
  string(0) ""
  ["search_order"]=>
  string(5) "-7480"
}
data partner
array(1) {
  [0]=>
  string(15) "johnson-johnson"
}


pi country
array(1) {
  [0]=>
  string(13) "United States"
}


pi affil
array(1) {
  [0]=>
  string(8) "Industry"
}


products
array(1) {
  [0]=>
  string(6) "invega"
}


num of trials
array(1) {
  [0]=>
  string(1) "2"
}


res
array(1) {
  [0]=>
  string(1) "3"
}