External Review by Nihar Desai – 07/12/2021 – 6:26pm

Data Request Number: 2021-4703 Is the scientific purpose of the research proposal clearly described?: Yes Will proposed research create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Yes, or it’s highly likely Does proposed research provide strong rationale for why the requested data can uniquely be used to address the proposed project aims? No Does proposed research provide clear justification for access outside the secure data sharing platform?: No Does proposed research describe the protections in place to ensure data security outside of the platform?: No Please use this space to provide any comments, feedback or concerns (optional):

I agree with the investigators that an exploration of the pharmacological and physiological effects of ketamine is clinically relevant and has potential public health importance. Similarly, I appreciate the need to pursue a meta-analytic approach. However, I am less clear on the rationale to obtain these data outside the SAS platform. The authors do not explain why this is necessary nor do they describe the requisite security/privacy and technical requirements for such a process.

Recommendation for this data request: Not Approve