Review by Cary Gross – 04/10/2020 – 8:18am

Data Request Number: 2020-4244 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Unsure, further clarification from requestor is needed Please use this space to provide any comments, feedback or concerns (optional):

Need to clarify – are they using patient-level meta-analysis?  The beginning of the methods implies that summary data will be assessed for trial-level, but then they do not specify the subsequent approach – is their primary approach meta-regression or IPD?

Recommendation for this data request: Not Approve

see above