Review by Cary Gross – 04/12/2021 – 2:30pm

Data Request Number: 2021-4649 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Unsure, further clarification from requestor is needed Please use this space to provide any comments, feedback or concerns (optional):

the proposal addresses an important question and while the analytic plan is somewhat vague due to the fact that the protocol is in development, the main idea is reasonable. I’d suggest conditional approval, contingent up on the investigators’ ability to access the RW data that they are working to obtain (without which the study isn’t feasible).

Recommendation for this data request: Approve