Review by Cary Gross – 05/17/2018 – 11:56am

Data Request Number: 2018-2946 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Yes, or it’s highly likely Please use this space to provide any comments, feedback or concerns (optional):

The investigators are encouraged to consider incorporating a comparisong group of patients who experienced CK-elevation but were not restarted on trabectedin. This would allow the Aim 3 analysis (outcomes are rechallenge) to provide more clinically relevant information.

Recommendation for this data request: Approve