Review by Cary Gross – 05/28/2020 – 11:33am

Data Request Number: 2020-4311 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Yes, or it’s highly likely Please use this space to provide any comments, feedback or concerns (optional):

The investigators should clarify that they are assessing a prognostic biomarker (i.e. is NLR independently associated with clinical outcome), rather than a predictive biomarker (does NLR level help to stratify patients according to effectiveness of reatment (i.e. is abiraterone more effective in patients with certain NLR levels than in others).

Recommendation for this data request: Approve