Review by [current-user:field-firstname] [current-user:field-lastname] – 08/14/2019 – 4:31pm

Data Request Number: 2019-3936 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Yes, or it’s highly likely Please use this space to provide any comments, feedback or concerns (optional):

This revised data request addresses a number of the questions raised after the first review of the proposal. However, it is still unclear whether the requested trials will fulfill the eligibility criteria. The investigators note that the trials must have missing not at random as part of the design, with a substantial porpotion of drop-out. It seems as if the investigators could have reviewed some of the trial specific information regarding drop-out (e.g. or the corresponding publications) to determine potential eligibility. That being said, if the investigators are able to identify an eligible trial, this work has the potential address a gap in the statistical literature.

Recommendation for this data request: Approve