Review by Harlan Krumholz – 06/13/2019 – 3:39pm

Data Request Number: 2019-3864 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Unsure, further clarification from requestor is needed Please use this space to provide any comments, feedback or concerns (optional):

I can pass it but I am unclear what YODA data will be used.
The criteria we looked for when selecting studies were completed or no longer active late phase HIV related trials with preference placed on intervention over observational studies. These datasets include Electronic Health Records (EHR) and claims data from CMS and the Greater Plains Collaborative, as well as the Lung HIV study from the National Heart Lung and Blood Insitutetrial platform, studies from the National Institute of Allergy and Infectious Diseases HIV Trial Networks, and multiple still to be determined clinical trials from Vivli and

Recommendation for this data request: Approve