Review by Joseph Ross – 03/19/2020 – 8:39am

Data Request Number: 2020-4236 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Yes, or it’s highly likely Please use this space to provide any comments, feedback or concerns (optional):

Interesting proposal. Would strongly suggest the authors take advantage of both arms of this RCT and characterize blood pressure changes among patients randomized to receive Ibrutinib and Chlorambucil, with interaction analyses or stratification by patients’ known history of hypertension.

Recommendation for this data request: Approve