Review by Joseph Ross – 07/17/2019 – 8:22am

Data Request Number: 2019-3936 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Yes, or it’s highly likely Please use this space to provide any comments, feedback or concerns (optional):

This is an interesting proposal to apply an item response theory framework for adjusting patient centered outcome-based scores ascertained from clinical trials for patient drop-out that occurs at random. While it is clear that this statistical approach is typically used for quality of life measures, the authors do not specify which quality of life measure they intend to use for each of the 6 trials requested. It would improve the proposal if the authors were to provide this information.

Recommendation for this data request: Approve