Review by Joseph Ross – 07/17/2019 – 8:35am

Data Request Number: 2019-3938 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Yes, or it’s highly likely Recommendation for this data request: Not Approve

This is an interesting data science research proposal to train machine learning models to help determine when adjuncts to antidepressants would be useful in an effort to reduce time to recovery, using data from 2 clinical trials. However, the requestor explained that “I am not analyzing participant-level data / I will not be using these software for analyses in the secure platform”. At this time, data are only available via the secure platform, except in rare circumstances.