Review by Joseph Ross – 07/26/2020 – 6:12pm

Data Request Number: 2020-4386 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Yes, or it’s highly likely Please use this space to provide any comments, feedback or concerns (optional):

Useful proposed research to develop a pharmacokinetic model to describe the relationship between dose and response over time for several disease-related variables such as lymphocyte count and lymph node size, that can be used to predict both disease progression and survival, as well as hypertension, an important side effect of therapy.

Recommendation for this data request: Approve