The proposal focuses on meta-analyzing control-arm data from anti-epilepsy clinical trials conducted among children, generating a placebo response-effect estimate. While this is important and will be of great use to science and future drug development efforts, more information is needed on what additional trials have been identified for inclusion in the meta-analysis, whether individual participant-level data (IPD) are available from these trials, whether this data will be uploaded to the secure data sharing platform to be analyzed along with the data made available from Janssen via the YODA Project, and if IPD are not available from other trials, whether summary-level data would suffice for meta-analysis. In addition, please pre-specify likely predictor variables of interest (sex, race, seizure disorder type, etc.).