Review by Joseph Ross – 10/25/2019 – 3:21pm

Data Request Number: 2019-4035 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Yes, or it’s highly likely Please use this space to provide any comments, feedback or concerns (optional):

The authors are likely to identify additional trials besides the 2 requested that assess the efficacy of SGLT-2 inhibitors and GLP-1 agonists versus placebo in patient with type 2 diabetes mellitus on cardiovascular outcomes. Will all the data be uploaded to the platform? Or is the purpose to use these data from the 2 trials, conduct the appropriate analyses, and then merge the summary data with already calculated estimates from previously acquired trials? I believe it’s the latter, which should just be explained a bit more clearly.

Recommendation for this data request: Approve