Review by Joseph Ross – 11/16/2017 – 4:38pm

Data Request Number: No Data Request Assigned Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Yes, or it’s highly likely Please use this space to provide any comments, feedback or concerns (optional):

There are some typos and grammatical errors in the research proposal that the investigators may want to fix. Nevertheless, its an intriguing proposal of a useful scientific question. A bit more information in the statistical analysis section would be useful, including what analytic techniques will be used to meta-analyze the many listed endpoints for the 3 trials and whether the investigators will account for multiple comparisons. Would also suggest being more specific and listing no more than 1 or 2 primary endpoints of the meta-analysis, and relegating the remaining 8 or 9 endpoints that are currently designated as primary to instead be listed as secondary.

Recommendation for this data request: Approve