Review by Joseph Ross – 11/19/2020 – 5:09pm

Data Request Number: 2020-4521 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Yes, or it’s highly likely Please use this space to provide any comments, feedback or concerns (optional):

Very few details are provided on the statistical analysis, just reference to the authors prior work on the topic. While not required, it would have been nice to have been provided with more information as part of the protocol to better understand the proposed methods for generalizing/transporting treatment effects from multiple clinical trials to a target population in the presence of systematic missing data.

Recommendation for this data request: Approve