Review by Nihar Desai – 03/28/2017 – 11:38am

Data Request Number: 2017-1466 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Unsure, further clarification from requestor is needed Please use this space to provide any comments, feedback or concerns (optional):

This is an interesting proposal and using empirical, data driven approaches to study heterogeneity in the response to therapy is a very important area of investigation. However, the clinical trials are limited to sitagliptin and canagliflozin so you will only have these effects.  In addition, how much difference was there in HbA1c?  Was there substantial enough variation to do an analysis like the one the author’s propose.

Recommendation for this data request: Not Approve