Review by Nihar Desai – 04/01/2019 – 1:53pm

Data Request Number: 2019-3850 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Unsure, further clarification from requestor is needed Can the proposed research be reasonably addressed using the requested data?: Unsure, further clarification from requestor is needed Please use this space to provide any comments, feedback or concerns (optional):

This is an interesting proposal — I am a bit unclear on how the investigators take a randomized trial and then develop a better measure of covariate balancing. I see the application for real world analyses and the potential to improve upon propensity score matching but its utility and deployment within a randomized trial is unclear.

Recommendation for this data request: Not Approve