Review by Nihar Desai – 12/18/2018 – 3:27pm

Data Request Number: 2018-3476 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Yes, or it’s highly likely Please use this space to provide any comments, feedback or concerns (optional):

For the quantitative phenotyping, have the investigators prespecified all the variables or will they also do unsupervised learning to identify other important predictive features? Will there be a validation cohort?

Recommendation for this data request: Approve