Review by Richard Lehman – 02/28/2017 – 7:03am

Data Request Number: 2017-1356 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Yes, or it’s highly likely Please use this space to provide any comments, feedback or concerns (optional):

This a simple analysis which is probably worth doing, though not for the reasons given. By the time the participants have metastatic cancer and have received other forms of androgen deprivation therapy, chemotherapy or corticosteroids, their BMI may have changed greatly from the time of onset of their cancer, so the mechanistic justification for the analysis does not hold. It is unlikely that the data set will contain any information about BMI at the time of initial diagnosis.

Recommendation for this data request: Approve