Review by Richard Lehman – 03/07/2018 – 12:16pm

Data Request Number: 2018-2801 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Yes, or it’s highly likely Please use this space to provide any comments, feedback or concerns (optional):

I fully support the requestors’ aims but there are some obscurities in their language, e.g. “Re-dig the value of failed drugs and/or wiser use of approved drugs could &c”
The choice of the abiraterone studies also introduces a lot of complexity as it will hard to distinguish the possible adverse effects of the drug from the effects of disease progression.
However, on balance I support this proposed use of the data.

Recommendation for this data request: Approve