“Co-morbidity” is a very general term and it needs to be specified much more clearly in relation to the participants of these condition-specific trials. The example given (CVD /COPD) does not apply to any of them.No
The trials requested mostly give data for conditions seen in younger patients, who may have various types of co-morbidity related to the disease in question but are unlikely to have high rates of other comorbidities. As previously stated, I don’t think the research question has been framed with sufficient clarity. What is the pre-specified hypothesis? Is this just a data trawl for associations? Which co-morbidities are being looked for? Why?No
I do not think the research question is clear.Not Approve
The research question is unclear and does not prespecify the associations being looked for.