Review by Richard Lehman – 08/05/2021 – 12:33pm

Data Request Number: 2021-4683 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Yes Can the proposed research be reasonably addressed using the requested data?: Unsure, would defer to Data Holder Due Diligence Assessment Please use this space to provide any comments, feedback or concerns (optional):

This is a very ambitious scoping project looking for associations between antiinfective drug prescribing and measures of progression or amelioration across a range of neurological conditions. The requestors have asked for datasets from a range of trials. The validity of their findings will depend critically on the availability of detailed prescribing information and on the use of statistical analysis which can cope with great heterogeneity in outcome measures. I think the Data Holder will need to ensure that such information is uniformly available. Anti-infective drugs are usually prescribed over short periods of time varying from a single dose to a week or two. I am rather doubtful whether this information is consistently available in all the trials requested. 

Recommendation for this data request: Not Approve

See comments above.