Review by Richard Lehman – 10/27/2020 – 12:06pm

Data Request Number: 2020-4444 Is the scientific purpose of the research proposal clearly described?: Yes Will request create or materially enhance generalizable scientific and/or medical knowledge to inform science and public health?: Unsure, further clarification from requestor is needed Can the proposed research be reasonably addressed using the requested data?: Unsure, further clarification from requestor is needed Please use this space to provide any comments, feedback or concerns (optional):

I don’t want to stand in the way of a potentially useful analysis, whose merits could be assessed after publication. To some extent the applicant has addressed my earlier caveat about the use of a surrogate measure of treatment expectation, by stating that the analysis will depend on there being a direct record of such expectation embedded in the IPD. I don’t know how likely that is, and to find out will require full processing and deidentification of the 9 datasets requested. I am not sure if the applicant has the support of a full statistical team in this exploration – “This project is for fulfillment of an undergraduate senior thesis.” 

Recommendation for this data request: Not Approve

Despite my reservations, I would be happy to accept if others feel that this sufficiently meets YODA criteria.