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2014-0291 — Comparative effectiveness of tumor necrosis factor alpha inhibitors in ankylosing spondylitis
Data RequestTumor necrosis factor alpha inhibitors (TNFi) are mainstay treatment for ankylosing spondylitis. Five TNFi have been approved in the United…
2014-0317 — Risperidone for conduct problems: do improved indicators of emotional dysregulation mediate improved behavioral outcomes?
Data RequestNational medical care data show that the treatment of childhood-onset conduct disorder (CD) with risperidone has increased markedly in the…
2014-0333 — RECIST response as a surrogate endpoint in metastatic castration-resistant prostate cancer: Retrospective analysis of COU-AA-302 and COU-AA-301
Data RequestAdvanced prostate cancer has been plagued by the lack of an optimal endpoint to rapidly assess the anti-tumor activity of…
2014-0334 — Gender Differences in Weight Gain in Patients with Inflammatory Bowel Disease Treated with Infliximab
Data RequestWomen frequently ask if anti-TNFs result in weight gain; high drug levels may cause weight gain. We will compare weight…
2014-0340 — The effects of SGLT-2 inhibitors in patients with type 2 diabetes: a systematic review with meta-analysis of randomised trials
Data RequestThe study will evaluate the effect of SGLT-2i in patients with type 2 diabetes based on the available published and…
2014-0364 — Initial severity and efficacy of antipsychotics for schizophrenia and bipolar mania: Individual patient level analyses of placebo-controlled trials
Data RequestThe belief that psychiatric drugs are more damaging than helpful has been recently revived based on reports that questioned their…
2014-0401 — Can Machine Learning Algorithms using General Labs Predict Biologic Remission for Patients on Thiopurines in the SONIC trial?
Data RequestWe have applied machine learning to common lab values to predict biologic remission in patients with inflammatory bowel disease in…
2015-0339 — Impact of the dose of immunomodulators on pharmacokinetics of biologics: Patient level meta-analysis of randomized controlled trials
Data RequestAntibody-based therapies, termed biologics, are highly effective in treating immune disorders. Many patients, however, lose response to treatment due to…
2015-0416 — Bone safety of canagliflozin, aSGLT2 inhibitor, in type 2 diabetes: A retrospective analysis to evaluate fracture risk
Data RequestDiabetes increases the risk for bone fractures. Therefore, when providers choose medications, understanding the safety profile is very important. We…
2015-0500 — Studying the Risk of Harmful Drug-Drug Interactions (DDI) in Patients with Castration-Resistant Prostate Cancer (CRPC) Treated with Abiraterone (ABI)
Data RequestABI is inactivated via cytochrome P450 (CYP) 3A4, and inhibits various CYPs involved in the metabolism of other drugs commonly…
2015-0514 — Comparison of 5-Day Course of Levofloxacin vs 10-Day Course of Ciprofloxacin Therapy in Males with Urinary Tract Infection
Data RequestInfections of the urinary tract caused by bacteria are a common occurrence in clinical practice. Although more common in females,…
2015-0522 — Impact of infliximab concentrations on combination therapy for Crohn’s disease
Data RequestInfliximab is a medication used for treatment of Crohn?s disease. One landmark randomized controlled trial of infliximab monotherapy compared to…
2015-0527 — Optimizing Infliximab in IBD: Developing a model to determine the optimal interval for monitoring infliximab concentrations
Data RequestInfliximab is an essential therapy for Inflammatory Bowel Disease (IBD). However the optimal dosing of infliximab remains uncertain. While historically…
2015-0560 — Construct and Content Validity of Instruments Used in Clinical Trials of Psoriatic Arthritis
Data RequestThe goals of this study are to 1) examine the correlation among outcome measures used in clinical trials of psoriatic…
2015-0565 — Understanding reasons for screen failures in late phase trials in advanced GU cancers
Data RequestIn clinical trials, screen failures are defined as subjects who consented to participate in research but who were disqualified during…
2015-0587 — Estimating the effect of bedaquiline on MDR-TB culture conversion and treatment outcomes using marginal structural models
Data RequestThis project will use a new analytical method ? marginal structural Cox proportional hazards modeling with inverse probability weighting ?…
2015-0612 — Impact of Obesity on Disease Course and Response to Biologic Therapy in Inflammatory Bowel Disease: A Post-Hoc Analysis of RCTs
Data RequestOver 1/3rd of adults in the United States are obese. Fat releases toxins that can cause several diseases like diabetes…
2015-0617 — Diagnostics for Informative Censoring in Efficacy and Effectiveness Trials of Schizophrenia Therapy
Data RequestRandomized trials are usually analyzed under the intention-to-treat design where participants are treated as if they fully adhered to their…
2015-0644 — Generalizing treatment effects for bipolar disorder and schizophrenia to the US population: Generalizability of network meta-analysis
Data RequestThis project will help researchers generalize, apply, and implement findings from network meta-analysis of randomized clinical trials to target populations.…
2015-0649 — Population Representativeness of Clinical Trial Study Samples
Data RequestPopulation representativeness of clinical trial study samples directly influences the generalizability of clinical trial results. We aim to develop a…
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