array(41) {
  ["project_title"]=>
  string(115) "Detection of uninformative clinics during the trial of a new drug using statistical and machine learning techniques"
  ["project_narrative_summary"]=>
  string(703) "Major Depressive Disorder affects 350 million people worldwide . Remission rates with standard therapies are 30-50% . No treatments with new mechanisms of action have been approved. For treatments that are  effective,  50% of clinical trials fail . A key determinant of this failure is the high variability in subjective clinical ratings and large placebo response rates.

The detection of uninformative centers at an early stage could lead to more efficient drug testing as noise level due to placebo response could be controlled.It is of great significance to find ways to recognize clinical centers which have a high probability of providing inaccurate data about the effect of drug and placebo."
  ["project_learn_source"]=>
  string(0) ""
  ["project_learn_source_exp"]=>
  string(0) ""
  ["project_key_personnel"]=>
  bool(false)
  ["project_ext_grants"]=>
  array(2) {
    ["value"]=>
    string(68) "No external grants or funds are being used to support this research."
    ["label"]=>
    string(68) "No external grants or funds are being used to support this research."
  }
  ["project_funding_source"]=>
  string(7) "Holmusk"
  ["project_assoc_trials"]=>
  array(37) {
    [0]=>
    object(WP_Post)#4752 (24) {
      ["ID"]=>
      int(1105)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 10:10:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 10:10:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(190) "NCT00307684 - An Open International Multicentre Long-Term Follow Up Study to Evaluate Safety of Prolonged Release OROS Methlyphenidate in Adults With Attention Deficit Hyperactivity Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(188) "nct00307684-an-open-international-multicentre-long-term-follow-up-study-to-evaluate-safety-of-prolonged-release-oros-methlyphenidate-in-adults-with-attention-deficit-hyperactivity-disorder"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:11:47"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:11:47"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(237) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00307684-an-open-international-multicentre-long-term-follow-up-study-to-evaluate-safety-of-prolonged-release-oros-methlyphenidate-in-adults-with-attention-deficit-hyperactivity-disorder/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [1]=>
    object(WP_Post)#4751 (24) {
      ["ID"]=>
      int(1107)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 10:16:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 10:16:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(250) "NCT00326300 - An Open-Label, Dose-Titration, Long-Term Safety Study to Evaluate CONCERTA (Methylphenidate HCL) Extended-release Tablets at Doses of 36 mg, 54 mg, 72 mg, 90 mg, and 108 mg Per Day in Adults With Attention Deficit Hyperactivity Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(190) "nct00326300-an-open-label-dose-titration-long-term-safety-study-to-evaluate-concerta-methylphenidate-hcl-extended-release-tablets-at-doses-of-36-mg-54-mg-72-mg-90-mg-and-108-mg-per-day-in-ad"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:11:50"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:11:50"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(239) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00326300-an-open-label-dose-titration-long-term-safety-study-to-evaluate-concerta-methylphenidate-hcl-extended-release-tablets-at-doses-of-36-mg-54-mg-72-mg-90-mg-and-108-mg-per-day-in-ad/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [2]=>
    object(WP_Post)#4750 (24) {
      ["ID"]=>
      int(1109)
      ["post_author"]=>
      string(3) "190"
      ["post_date"]=>
      string(19) "2014-09-22 10:23:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 10:23:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(309) "NCT00246220 - A Multicentre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group, Dose-Response Study To Evaluate the Safety And Efficacy Of Prolonged Release OROS Methylphenidate Hydrochloride (18, 36 and 72 mg/Day), With Open-Label Extension, In Adults With Attention Deficit/Hyperactivity Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(6) "closed"
      ["ping_status"]=>
      string(6) "closed"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(193) "nct00246220-a-multicentre-randomised-double-blind-placebo-controlled-parallel-group-dose-response-study-to-evaluate-the-safety-and-efficacy-of-prolonged-release-oros-methylphenidate-hydrochlori"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-05-18 17:49:34"
      ["post_modified_gmt"]=>
      string(19) "2023-05-18 17:49:34"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(242) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00246220-a-multicentre-randomised-double-blind-placebo-controlled-parallel-group-dose-response-study-to-evaluate-the-safety-and-efficacy-of-prolonged-release-oros-methylphenidate-hydrochlori/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [3]=>
    object(WP_Post)#4749 (24) {
      ["ID"]=>
      int(1156)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 12:21:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 12:21:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(263) "NCT01009047 - A Randomized, Multicenter, Double-Blind, Active-Controlled, Flexible-Dose, Parallel-Group Study of the Efficacy and Safety of Prolonged Release Paliperidone for the Treatment of Symptoms of Schizophrenia in Adolescent Subjects, 12 to 17 Years of Age"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(193) "nct01009047-a-randomized-multicenter-double-blind-active-controlled-flexible-dose-parallel-group-study-of-the-efficacy-and-safety-of-prolonged-release-paliperidone-for-the-treatment-of-symptoms"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:13:06"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:13:06"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(242) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01009047-a-randomized-multicenter-double-blind-active-controlled-flexible-dose-parallel-group-study-of-the-efficacy-and-safety-of-prolonged-release-paliperidone-for-the-treatment-of-symptoms/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [4]=>
    object(WP_Post)#4748 (24) {
      ["ID"]=>
      int(1159)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 12:23:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 12:23:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(170) "NCT00645099 - A Prospective Randomized Open-label 6-Month Head-To-Head Trial to Compare Metabolic Effects of Paliperidone ER and Olanzapine in Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(168) "nct00645099-a-prospective-randomized-open-label-6-month-head-to-head-trial-to-compare-metabolic-effects-of-paliperidone-er-and-olanzapine-in-subjects-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-05-02 09:38:41"
      ["post_modified_gmt"]=>
      string(19) "2024-05-02 13:38:41"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(217) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00645099-a-prospective-randomized-open-label-6-month-head-to-head-trial-to-compare-metabolic-effects-of-paliperidone-er-and-olanzapine-in-subjects-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [5]=>
    object(WP_Post)#4747 (24) {
      ["ID"]=>
      int(1162)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 12:29:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 12:29:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(262) "NCT00518323 - A Randomized, Multicenter, Double-Blind, Weight-Based, Fixed-Dose, Parallel-Group, Placebo-Controlled Study of the Efficacy and Safety of Extended Release Paliperidone for the Treatment of Schizophrenia in Adolescent Subjects, 12 to 17 Years of Age"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(191) "nct00518323-a-randomized-multicenter-double-blind-weight-based-fixed-dose-parallel-group-placebo-controlled-study-of-the-efficacy-and-safety-of-extended-release-paliperidone-for-the-treatment"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-03-26 11:54:17"
      ["post_modified_gmt"]=>
      string(19) "2024-03-26 15:54:17"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(240) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00518323-a-randomized-multicenter-double-blind-weight-based-fixed-dose-parallel-group-placebo-controlled-study-of-the-efficacy-and-safety-of-extended-release-paliperidone-for-the-treatment/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [6]=>
    object(WP_Post)#4746 (24) {
      ["ID"]=>
      int(1165)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 14:23:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 14:23:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(198) "NCT01606228 - An Open-Label Prospective Trial to Explore the Tolerability, Safety and Efficacy of Flexibly-Dosed Paliperidone ER among Treatment-Naive and Newly Diagnosed Patients with Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(195) "nct01606228-an-open-label-prospective-trial-to-explore-the-tolerability-safety-and-efficacy-of-flexibly-dosed-paliperidone-er-among-treatment-naive-and-newly-diagnosed-patients-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:13:15"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:13:15"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(244) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01606228-an-open-label-prospective-trial-to-explore-the-tolerability-safety-and-efficacy-of-flexibly-dosed-paliperidone-er-among-treatment-naive-and-newly-diagnosed-patients-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [7]=>
    object(WP_Post)#4745 (24) {
      ["ID"]=>
      int(1166)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 14:26:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 14:26:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(216) "NCT00334126 - A Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Paliperidone ER Compared to Quetiapine in Subjects With an Acute Exacerbation of Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(194) "nct00334126-a-randomized-double-blind-placebo-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-paliperidone-er-compared-to-quetiapine-in-subjects-with-an-acute-exacerbation"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:13:19"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:13:19"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(243) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00334126-a-randomized-double-blind-placebo-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-paliperidone-er-compared-to-quetiapine-in-subjects-with-an-acute-exacerbation/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [8]=>
    object(WP_Post)#4744 (24) {
      ["ID"]=>
      int(1169)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 14:30:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 14:30:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(223) "NCT00086320 - A Randomized, Double-blind, Placebo-controlled, Parallel-group Study With an Open-label Extension Evaluating Paliperidone Extended Release Tablets in the Prevention of Recurrence in Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(195) "nct00086320-a-randomized-double-blind-placebo-controlled-parallel-group-study-with-an-open-label-extension-evaluating-paliperidone-extended-release-tablets-in-the-prevention-of-recurrence-in-subj"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:13:23"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:13:23"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(244) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00086320-a-randomized-double-blind-placebo-controlled-parallel-group-study-with-an-open-label-extension-evaluating-paliperidone-extended-release-tablets-in-the-prevention-of-recurrence-in-subj/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [9]=>
    object(WP_Post)#4743 (24) {
      ["ID"]=>
      int(1175)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 14:35:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 14:35:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(220) "NCT00589914 - A Randomized, Double-Blind, Parallel-Group, Comparative Study of Flexible Doses of Paliperidone Palmitate and Flexible Doses of Risperidone Long-Acting Intramuscular Injection in Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(195) "nct00589914-a-randomized-double-blind-parallel-group-comparative-study-of-flexible-doses-of-paliperidone-palmitate-and-flexible-doses-of-risperidone-long-acting-intramuscular-injection-in-subject"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-03-25 17:30:56"
      ["post_modified_gmt"]=>
      string(19) "2024-03-25 21:30:56"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(244) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00589914-a-randomized-double-blind-parallel-group-comparative-study-of-flexible-doses-of-paliperidone-palmitate-and-flexible-doses-of-risperidone-long-acting-intramuscular-injection-in-subject/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [10]=>
    object(WP_Post)#4742 (24) {
      ["ID"]=>
      int(1178)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 14:37:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 14:37:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(191) "NCT00604279 - A Randomized, Open-Label, Parallel Group Comparative Study of Paliperidone Palmitate (50, 100, 150 mg eq) and Risperidone LAI (25, 37.5, or 50 mg) in Subjects with Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(179) "nct00604279-a-randomized-open-label-parallel-group-comparative-study-of-paliperidone-palmitate-50-100-150-mg-eq-and-risperidone-lai-25-37-5-or-50-mg-in-subjects-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:13:37"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:13:37"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(228) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00604279-a-randomized-open-label-parallel-group-comparative-study-of-paliperidone-palmitate-50-100-150-mg-eq-and-risperidone-lai-25-37-5-or-50-mg-in-subjects-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [11]=>
    object(WP_Post)#4741 (24) {
      ["ID"]=>
      int(1181)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:13:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:13:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(247) "NCT00590577 - A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose Response Study to Evaluate the Efficacy and Safety of 3 Fixed Doses (25 mg eq., 100 mg eq., and 150 mg eq.) of Paliperidone Palmitate in Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(187) "nct00590577-a-randomized-double-blind-placebo-controlled-parallel-group-dose-response-study-to-evaluate-the-efficacy-and-safety-of-3-fixed-doses-25-mg-eq-100-mg-eq-and-150-mg-eq-of-palipe"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:13:42"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:13:42"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(236) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00590577-a-randomized-double-blind-placebo-controlled-parallel-group-dose-response-study-to-evaluate-the-efficacy-and-safety-of-3-fixed-doses-25-mg-eq-100-mg-eq-and-150-mg-eq-of-palipe/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [12]=>
    object(WP_Post)#4740 (24) {
      ["ID"]=>
      int(1184)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:22:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:22:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(244) "NCT00111189 - A Randomized Double-blind Placebo-controlled Parallel Group Study Evaluating Paliperidone Palmitate in the Prevention of Recurrence in Patients With Schizophrenia. Placebo Consists of 20% Intralipid (200 mg/mL) Injectable Emulsion"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(197) "nct00111189-a-randomized-double-blind-placebo-controlled-parallel-group-study-evaluating-paliperidone-palmitate-in-the-prevention-of-recurrence-in-patients-with-schizophrenia-placebo-consists-of-20"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-03-26 10:14:14"
      ["post_modified_gmt"]=>
      string(19) "2024-03-26 14:14:14"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(246) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00111189-a-randomized-double-blind-placebo-controlled-parallel-group-study-evaluating-paliperidone-palmitate-in-the-prevention-of-recurrence-in-patients-with-schizophrenia-placebo-consists-of-20/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [13]=>
    object(WP_Post)#4739 (24) {
      ["ID"]=>
      int(1193)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:33:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:33:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(247) "NCT00210548 - A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Response Study to Evaluate the Efficacy and Safety of 3 Fixed Doses (50 mg eq., 100 mg eq., and 150 mg eq.) of Paliperidone Palmitate in Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(187) "nct00210548-a-randomized-double-blind-placebo-controlled-parallel-group-dose-response-study-to-evaluate-the-efficacy-and-safety-of-3-fixed-doses-50-mg-eq-100-mg-eq-and-150-mg-eq-of-palipe"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-03-26 10:15:28"
      ["post_modified_gmt"]=>
      string(19) "2024-03-26 14:15:28"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(236) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00210548-a-randomized-double-blind-placebo-controlled-parallel-group-dose-response-study-to-evaluate-the-efficacy-and-safety-of-3-fixed-doses-50-mg-eq-100-mg-eq-and-150-mg-eq-of-palipe/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [14]=>
    object(WP_Post)#4738 (24) {
      ["ID"]=>
      int(1196)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:35:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:35:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(243) "NCT00101634 - A Randomized, Double-blind, Placebo-controlled, Parallel-group, Dose-response Study to Evaluate the Efficacy and Safety of 3 Fixed Doses (25 mg eq, 50 mg eq, and 100 mg eq) of Paliperidone Palmitate in Patients With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(190) "nct00101634-a-randomized-double-blind-placebo-controlled-parallel-group-dose-response-study-to-evaluate-the-efficacy-and-safety-of-3-fixed-doses-25-mg-eq-50-mg-eq-and-100-mg-eq-of-paliperido"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:04"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:04"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(239) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00101634-a-randomized-double-blind-placebo-controlled-parallel-group-dose-response-study-to-evaluate-the-efficacy-and-safety-of-3-fixed-doses-25-mg-eq-50-mg-eq-and-100-mg-eq-of-paliperido/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [15]=>
    object(WP_Post)#4737 (24) {
      ["ID"]=>
      int(1199)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:40:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:40:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(261) "NCT00391222 - A Randomized, Double Blind, Placebo and Active Controlled Parallel Group Study to Evaluate the Efficacy and Safety of Risperidone Long-acting Injectable (LAI) for the Prevention of Mood Episodes in the Treatment of Subjects With Bipolar I Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(193) "nct00391222-a-randomized-double-blind-placebo-and-active-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-risperidone-long-acting-injectable-lai-for-the-prevention-of-mood"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:10"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:10"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(242) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00391222-a-randomized-double-blind-placebo-and-active-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-risperidone-long-acting-injectable-lai-for-the-prevention-of-mood/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [16]=>
    object(WP_Post)#4736 (24) {
      ["ID"]=>
      int(1202)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:43:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:43:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(134) "NCT00034749 - The Efficacy and Safety of Risperidone in Adolescents With Schizophrenia: a Comparison of Two Dose Ranges of Risperidone"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(131) "nct00034749-the-efficacy-and-safety-of-risperidone-in-adolescents-with-schizophrenia-a-comparison-of-two-dose-ranges-of-risperidone"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:14"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:14"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(180) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00034749-the-efficacy-and-safety-of-risperidone-in-adolescents-with-schizophrenia-a-comparison-of-two-dose-ranges-of-risperidone/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [17]=>
    object(WP_Post)#4735 (24) {
      ["ID"]=>
      int(1205)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:45:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:45:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(265) "NCT00076115 - Research on the Effectiveness of Risperidone in Bipolar Disorder in Adolescents and Children (REACH): A Double-Blind, Randomized, Placebo-Controlled Study of the Efficacy and Safety of Risperidone for the Treatment of Acute Mania in Bipolar I Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(193) "nct00076115-research-on-the-effectiveness-of-risperidone-in-bipolar-disorder-in-adolescents-and-children-reach-a-double-blind-randomized-placebo-controlled-study-of-the-efficacy-and-safety-of-r"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:18"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:18"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(242) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00076115-research-on-the-effectiveness-of-risperidone-in-bipolar-disorder-in-adolescents-and-children-reach-a-double-blind-randomized-placebo-controlled-study-of-the-efficacy-and-safety-of-r/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [18]=>
    object(WP_Post)#4734 (24) {
      ["ID"]=>
      int(1208)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:47:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:47:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(237) "NCT00132678 - A Randomized, Double-blind, Placebo-controlled Study to Explore the Efficacy and Safety of Risperidone Long-acting Intramuscular Injectable in the Prevention of Mood Episodes in Bipolar 1 Disorder, With Open-label Extension"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(195) "nct00132678-a-randomized-double-blind-placebo-controlled-study-to-explore-the-efficacy-and-safety-of-risperidone-long-acting-intramuscular-injectable-in-the-prevention-of-mood-episodes-in-bipolar"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:23"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:23"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(244) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00132678-a-randomized-double-blind-placebo-controlled-study-to-explore-the-efficacy-and-safety-of-risperidone-long-acting-intramuscular-injectable-in-the-prevention-of-mood-episodes-in-bipolar/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [19]=>
    object(WP_Post)#4733 (24) {
      ["ID"]=>
      int(1211)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:50:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:50:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(205) "NCT00094926 - A Prospective, Randomized, Double-blind, Placebo-controlled Study of the Effectiveness and Safety of RISPERDAL CONSTA Augmentation in Adult Patients With Frequently-relapsing Bipolar Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(195) "nct00094926-a-prospective-randomized-double-blind-placebo-controlled-study-of-the-effectiveness-and-safety-of-risperdal-consta-augmentation-in-adult-patients-with-frequently-relapsing-bipolar-dis"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:27"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:27"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(244) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00094926-a-prospective-randomized-double-blind-placebo-controlled-study-of-the-effectiveness-and-safety-of-risperdal-consta-augmentation-in-adult-patients-with-frequently-relapsing-bipolar-dis/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [20]=>
    object(WP_Post)#4732 (24) {
      ["ID"]=>
      int(1220)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-10-13 12:13:00"
      ["post_date_gmt"]=>
      string(19) "2014-10-13 12:13:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(264) "NCT00714688 - A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Dose-Response Study to Evaluate Efficacy and Safety of Prolonged Release (PR) OROS Methylphenidate (54 and 72 mg/Day) in Adults With Attention Deficit/Hyperactivity Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(190) "nct00714688-a-multicentre-randomized-double-blind-placebo-controlled-parallel-group-dose-response-study-to-evaluate-efficacy-and-safety-of-prolonged-release-pr-oros-methylphenidate-54-and-72"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:37"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:37"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(239) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00714688-a-multicentre-randomized-double-blind-placebo-controlled-parallel-group-dose-response-study-to-evaluate-efficacy-and-safety-of-prolonged-release-pr-oros-methylphenidate-54-and-72/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [21]=>
    object(WP_Post)#4731 (24) {
      ["ID"]=>
      int(1222)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-10-20 14:15:00"
      ["post_date_gmt"]=>
      string(19) "2014-10-20 14:15:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(223) "NCT00866996 - A Multi-center Randomized Parallel Group Study Evaluating Treatment Outcomes of Concerta (Extended Release Methylphenidate) and Strattera (Atomoxetine) in Children With Attention-deficit/Hyperactivity Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(194) "nct00866996-a-multi-center-randomized-parallel-group-study-evaluating-treatment-outcomes-of-concerta-extended-release-methylphenidate-and-strattera-atomoxetine-in-children-with-attention-deficit"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:42"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:42"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(243) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00866996-a-multi-center-randomized-parallel-group-study-evaluating-treatment-outcomes-of-concerta-extended-release-methylphenidate-and-strattera-atomoxetine-in-children-with-attention-deficit/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [22]=>
    object(WP_Post)#4730 (24) {
      ["ID"]=>
      int(1225)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-10-20 14:28:00"
      ["post_date_gmt"]=>
      string(19) "2014-10-20 14:28:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(100) "NCT00269815 - Long-term Safety and Effectiveness of OROS (Methylphenidate HCl) in Children With ADHD"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(96) "nct00269815-long-term-safety-and-effectiveness-of-oros-methylphenidate-hcl-in-children-with-adhd"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:44"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:44"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(145) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00269815-long-term-safety-and-effectiveness-of-oros-methylphenidate-hcl-in-children-with-adhd/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [23]=>
    object(WP_Post)#4729 (24) {
      ["ID"]=>
      int(1227)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-10-20 14:30:00"
      ["post_date_gmt"]=>
      string(19) "2014-10-20 14:30:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(211) "NCT00397033 - A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy and Safety of Two Dosages of Paliperidone ER in the Treatment of Patients With Schizoaffective Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(195) "nct00397033-a-randomized-double-blind-placebo-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-two-dosages-of-paliperidone-er-in-the-treatment-of-patients-with-schizoaffecti"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:48"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:48"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(244) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00397033-a-randomized-double-blind-placebo-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-two-dosages-of-paliperidone-er-in-the-treatment-of-patients-with-schizoaffecti/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [24]=>
    object(WP_Post)#4728 (24) {
      ["ID"]=>
      int(1230)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-10-20 14:32:00"
      ["post_date_gmt"]=>
      string(19) "2014-10-20 14:32:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(211) "NCT00412373 - A Randomized, Double-blind, Placebo-controlled, Parallel- Group Study to Evaluate the Efficacy and Safety of Flexible-dose Paliperidone ER in the Treatment of Patients With Schizoaffective Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(194) "nct00412373-a-randomized-double-blind-placebo-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-flexible-dose-paliperidone-er-in-the-treatment-of-patients-with-schizoaffecti"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:52"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:52"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(243) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00412373-a-randomized-double-blind-placebo-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-flexible-dose-paliperidone-er-in-the-treatment-of-patients-with-schizoaffecti/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [25]=>
    object(WP_Post)#4727 (24) {
      ["ID"]=>
      int(1233)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-10-20 14:34:00"
      ["post_date_gmt"]=>
      string(19) "2014-10-20 14:34:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(189) "NCT00236444 - Risperidone in the Prevention of Relapse: a Randomized, Double-blind, Placebo-controlled Trial in Children and Adolescents With Conduct and Other Disruptive Behavior Disorders"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(184) "nct00236444-risperidone-in-the-prevention-of-relapse-a-randomized-double-blind-placebo-controlled-trial-in-children-and-adolescents-with-conduct-and-other-disruptive-behavior-disorders"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:57"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:57"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(233) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00236444-risperidone-in-the-prevention-of-relapse-a-randomized-double-blind-placebo-controlled-trial-in-children-and-adolescents-with-conduct-and-other-disruptive-behavior-disorders/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [26]=>
    object(WP_Post)#4726 (24) {
      ["ID"]=>
      int(1236)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-10-20 14:42:00"
      ["post_date_gmt"]=>
      string(19) "2014-10-20 14:42:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(167) "NCT00236470 - Risperidone in the Treatment of Children and Adolescents With Conduct and Other Disruptive Behavior Disorders - an Open Label Follow-up Trial of CR002020"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(163) "nct00236470-risperidone-in-the-treatment-of-children-and-adolescents-with-conduct-and-other-disruptive-behavior-disorders-an-open-label-follow-up-trial-of-cr002020"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:15:01"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:15:01"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(212) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00236470-risperidone-in-the-treatment-of-children-and-adolescents-with-conduct-and-other-disruptive-behavior-disorders-an-open-label-follow-up-trial-of-cr002020/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [27]=>
    object(WP_Post)#4725 (24) {
      ["ID"]=>
      int(1239)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-10-20 14:45:00"
      ["post_date_gmt"]=>
      string(19) "2014-10-20 14:45:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(166) "NCT00250354 - The Safety And Efficacy Of Risperidone Versus Placebo In Conduct Disorder In Mild, Moderate And Borderline Mentally Retarded Children Aged 5 To 12 Years"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(163) "nct00250354-the-safety-and-efficacy-of-risperidone-versus-placebo-in-conduct-disorder-in-mild-moderate-and-borderline-mentally-retarded-children-aged-5-to-12-years"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:15:04"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:15:04"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(212) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00250354-the-safety-and-efficacy-of-risperidone-versus-placebo-in-conduct-disorder-in-mild-moderate-and-borderline-mentally-retarded-children-aged-5-to-12-years/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [28]=>
    object(WP_Post)#4724 (24) {
      ["ID"]=>
      int(1241)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-10-20 14:47:00"
      ["post_date_gmt"]=>
      string(19) "2014-10-20 14:47:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(206) "NCT00266552 - The Safety And Efficacy Of Risperidone Versus Placebo In Conduct Disorder and Other Disruptive Behavior Disorders In Mild, Moderate And Borderline Mentally Retarded Children Aged 5 To 12 Years"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(197) "nct00266552-the-safety-and-efficacy-of-risperidone-versus-placebo-in-conduct-disorder-and-other-disruptive-behavior-disorders-in-mild-moderate-and-borderline-mentally-retarded-children-aged-5-to-12"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:15:06"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:15:06"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(246) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00266552-the-safety-and-efficacy-of-risperidone-versus-placebo-in-conduct-disorder-and-other-disruptive-behavior-disorders-in-mild-moderate-and-borderline-mentally-retarded-children-aged-5-to-12/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [29]=>
    object(WP_Post)#4723 (24) {
      ["ID"]=>
      int(1327)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-01-30 12:12:00"
      ["post_date_gmt"]=>
      string(19) "2015-01-30 12:12:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(102) "NCT00253201 - Efficacy, Tolerability and Safety of Galantamine in the Treatment of Alzheimer's Disease"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(98) "nct00253201-efficacy-tolerability-and-safety-of-galantamine-in-the-treatment-of-alzheimers-disease"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:17:09"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:17:09"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(147) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00253201-efficacy-tolerability-and-safety-of-galantamine-in-the-treatment-of-alzheimers-disease/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [30]=>
    object(WP_Post)#4722 (24) {
      ["ID"]=>
      int(1333)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-01-30 12:18:00"
      ["post_date_gmt"]=>
      string(19) "2015-01-30 12:18:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(92) "NCT00253227 - Galantamine in the Treatment of Alzheimer's Disease: Flexible Dose Range Trial"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(88) "nct00253227-galantamine-in-the-treatment-of-alzheimers-disease-flexible-dose-range-trial"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:17:19"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:17:19"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(137) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00253227-galantamine-in-the-treatment-of-alzheimers-disease-flexible-dose-range-trial/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [31]=>
    object(WP_Post)#4721 (24) {
      ["ID"]=>
      int(1336)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-02-10 10:25:00"
      ["post_date_gmt"]=>
      string(19) "2015-02-10 10:25:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(62) "NCT00216502 - Long Term Treatment With Galantamine In Dementia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(60) "nct00216502-long-term-treatment-with-galantamine-in-dementia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:17:22"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:17:22"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(109) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00216502-long-term-treatment-with-galantamine-in-dementia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [32]=>
    object(WP_Post)#4720 (24) {
      ["ID"]=>
      int(1338)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-02-10 10:32:00"
      ["post_date_gmt"]=>
      string(19) "2015-02-10 10:32:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(191) "NCT00799409 - The ABC Study: A Double-Blind, Randomized, Placebo-Controlled, Crossover Study Evaluating the Academic, Behavioral, and Cognitive Effects of CONCERTA on Older Children With ADHD"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(183) "nct00799409-the-abc-study-a-double-blind-randomized-placebo-controlled-crossover-study-evaluating-the-academic-behavioral-and-cognitive-effects-of-concerta-on-older-children-with-adhd"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:17:24"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:17:24"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(232) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00799409-the-abc-study-a-double-blind-randomized-placebo-controlled-crossover-study-evaluating-the-academic-behavioral-and-cognitive-effects-of-concerta-on-older-children-with-adhd/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [33]=>
    object(WP_Post)#4719 (24) {
      ["ID"]=>
      int(1340)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-02-10 10:35:00"
      ["post_date_gmt"]=>
      string(19) "2015-02-10 10:35:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(189) "NCT00799487 - Double-Blind, Randomized, Placebo-Controlled, Crossover Study Evaluating the Academic, Behavioral and Cognitive Effects of CONCERTA on Older Children With ADHD (The ABC Study)"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(181) "nct00799487-double-blind-randomized-placebo-controlled-crossover-study-evaluating-the-academic-behavioral-and-cognitive-effects-of-concerta-on-older-children-with-adhd-the-abc-study"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:17:28"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:17:28"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(230) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00799487-double-blind-randomized-placebo-controlled-crossover-study-evaluating-the-academic-behavioral-and-cognitive-effects-of-concerta-on-older-children-with-adhd-the-abc-study/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [34]=>
    object(WP_Post)#4718 (24) {
      ["ID"]=>
      int(1356)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-07-16 10:24:00"
      ["post_date_gmt"]=>
      string(19) "2015-07-16 10:24:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(158) "NCT00249132 - A Canadian multicenter placebo-controlled study of fixed doses of risperidone and haloperidol in the treatment of chronic schizophrenic patients"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(156) "nct00249132-a-canadian-multicenter-placebo-controlled-study-of-fixed-doses-of-risperidone-and-haloperidol-in-the-treatment-of-chronic-schizophrenic-patients"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-04-24 10:08:05"
      ["post_modified_gmt"]=>
      string(19) "2024-04-24 14:08:05"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(205) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00249132-a-canadian-multicenter-placebo-controlled-study-of-fixed-doses-of-risperidone-and-haloperidol-in-the-treatment-of-chronic-schizophrenic-patients/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [35]=>
    object(WP_Post)#4717 (24) {
      ["ID"]=>
      int(1374)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-08-10 13:26:00"
      ["post_date_gmt"]=>
      string(19) "2015-08-10 13:26:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(176) "NCT00253162 - The Efficacy And Safety Of Flexible Dose Ranges Of Risperidone Versus Placebo Or Haloperidol In The Treatment Of Manic Episodes Associated With Bipolar I Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(174) "nct00253162-the-efficacy-and-safety-of-flexible-dose-ranges-of-risperidone-versus-placebo-or-haloperidol-in-the-treatment-of-manic-episodes-associated-with-bipolar-i-disorder"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:18:19"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:18:19"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(223) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00253162-the-efficacy-and-safety-of-flexible-dose-ranges-of-risperidone-versus-placebo-or-haloperidol-in-the-treatment-of-manic-episodes-associated-with-bipolar-i-disorder/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [36]=>
    object(WP_Post)#4716 (24) {
      ["ID"]=>
      int(1377)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-09-16 11:36:00"
      ["post_date_gmt"]=>
      string(19) "2015-09-16 11:36:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(140) "NCT00378092 - A Prospective Study of the Clinical Outcome Following Treatment Discontinuation After Remission in First-Episode Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(138) "nct00378092-a-prospective-study-of-the-clinical-outcome-following-treatment-discontinuation-after-remission-in-first-episode-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:18:22"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:18:22"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(187) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00378092-a-prospective-study-of-the-clinical-outcome-following-treatment-discontinuation-after-remission-in-first-episode-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
  }
  ["project_date_type"]=>
  string(91) "Individual Participant-Level Data, which includes Full CSR and all supporting documentation"
  ["property_scientific_abstract"]=>
  string(1598) "Background: Major Depressive Disorder affects 350 million people worldwide. No treatments with new mechanisms of action have been approved this century.

 For treatments that are effective,  50% of clinical trials fail.

Objective: The detection of uninformative centers at an early stage could lead to more efficient drug testing. It is significant to find ways to recognize clinical centers which have a high probability of providing inaccurate data about the effect of drug and placebo.

Study Design: The study is meta-analysis. Based on the results obtained from different clinical centers, a pattern is expected to be found which lead to classification of the centers into informative and uninformative. Standard machine learning and statistical techniques will be used.

Participants: Major Depressive Disorder patients.

Main Outcome Measure: Hamilton Depression Rating Score.

Statistical Analysis: 1. A multivariate logistic analysis to test statistical relationship between two placebo predictor variables (HAMD-17 score at baseline (P) and HAMD-17 score at the end of the study (F)) and the probability of detecting a signal of a clinically relevant treatment effect; 2. The posterior probability of the difference (P ? F) will be used for ranking the centers according to their performance within each individual trial; 3. Use standard machine learning techniques to identify and learn patterns in data which determine whether the data is informative or not with all the biometric and demographic features of the patient and along with the HAMD data, etc."
  ["project_brief_bg"]=>
  string(1078) "Major Depressive Disorder (MDD) affects 350 million people worldwide and is now the world's second leading cause of disability . Remission rates with standard therapies are 30-50% . Despite the significant unmet need, no treatments with new mechanisms of action have been approved this century. Over the last ten years the probability of success for new MDD drugs entering human testing has been 7.2% . Historically, for treatments that are known to be effective, up to 50% of clinical trials fail . A key determinant of this failure is the high variability in subjective clinical ratings and large placebo response rates.

The detection of uninformative centers at an early stage could lead to more efficient drug testing as the noise level in the data due to placebo response could be controlled. This would mean more reliable results in a shorter time-frame, and with a smaller number of subjects. It is thus of great significance to find ways to recognize clinical centers which have a high probability of providing inaccurate data about the effect of drug and placebo."
  ["project_specific_aims"]=>
  string(954) "The aim of the project is to detect uninformative centers at an early stage to lead to more efficient drug testing.

Our hypothesis is that poor quality endpoint data at a site level differs systematically from the general trial data, for example in variability, correlation between assessments or non-plausible placebo response trajectories generated in a given center. These systematic differences would allow detection of sites with poor quality data during the conduct of the trial. The aim of this study would be to develop a quantitative methodology to detect sites contributing poor quality data.

Blinded data from previous Major Depressive Disorder (MDD) trial will be divided into a training set and a test set to assess whether outlier sites can be detected and to determine the accuracy of such predictions. Our aim is to classify each recruitment center on an ongoing basis during patient accrual as informative or non-informative."
  ["project_study_design"]=>
  string(0) ""
  ["project_study_design_exp"]=>
  string(0) ""
  ["project_purposes"]=>
  array(6) {
    [0]=>
    array(2) {
      ["value"]=>
      string(114) "New research question to examine treatment effectiveness on secondary endpoints and/or within subgroup populations"
      ["label"]=>
      string(114) "New research question to examine treatment effectiveness on secondary endpoints and/or within subgroup populations"
    }
    [1]=>
    array(2) {
      ["value"]=>
      string(76) "Confirm or validate previously conducted research on treatment effectiveness"
      ["label"]=>
      string(76) "Confirm or validate previously conducted research on treatment effectiveness"
    }
    [2]=>
    array(2) {
      ["value"]=>
      string(32) "Summary-level data meta-analysis"
      ["label"]=>
      string(32) "Summary-level data meta-analysis"
    }
    [3]=>
    array(2) {
      ["value"]=>
      string(66) "Summary-level data meta-analysis using only data from YODA Project"
      ["label"]=>
      string(66) "Summary-level data meta-analysis using only data from YODA Project"
    }
    [4]=>
    array(2) {
      ["value"]=>
      string(36) "Participant-level data meta-analysis"
      ["label"]=>
      string(36) "Participant-level data meta-analysis"
    }
    [5]=>
    array(2) {
      ["value"]=>
      string(66) "Summary-level data meta-analysis using only data from YODA Project"
      ["label"]=>
      string(66) "Summary-level data meta-analysis using only data from YODA Project"
    }
  }
  ["project_purposes_exp"]=>
  string(0) ""
  ["project_software_used"]=>
  string(0) ""
  ["project_software_used_exp"]=>
  string(0) ""
  ["project_research_methods"]=>
  string(208) "We focus on placebo-controlled trials in ?Major Depressive Disorder? as these are the most common types of registration trial. We are interested in Clinical study Data for 'Major Depressive Disorder? studies."
  ["project_main_outcome_measure"]=>
  string(361) "The difference in Hamilton Depression Rating Scale (HAMD) score at the beginning and at the end of the studies will be analyzed. The HAMD score is a measure of depression, and the change in the score during a clinical trial is a measure of effectiveness of drug/placebo. Our study will find whether the change in HAMD scores in different clinics are consistent."
  ["project_main_predictor_indep"]=>
  string(299) "We want to focus our study on ?Major Depressive disorder?. For our analysis, we estimate that at least 5000-7000 data points may be necessary. For independent variables, we need biometric and demographic data, like age, gender, body mass index, disease history, smoking, drinking or other lifestyle."
  ["project_other_variables_interest"]=>
  string(3) "N/A"
  ["project_stat_analysis_plan"]=>
  string(1717) "Signal detection: 1. A multivariate logistic analysis to test statistical relationship between two placebo predictor variables (HAMD-17 score at baseline (P) and HAMD-17 score at the end of the study (F)) and the probability of detecting a signal of a clinically relevant treatment effect (the difference between end-of-study HAMD-17 score of active treatment andplacebo); 2. A probabilistic threshold derived from an ROC curve analysis to classify clinical centers as informative.

Non linear longitudinal modeling:  Estimating treatment effect by associating a weighting factor to the data collected at clinical centers. The weight will be defined by the posterior probability of detecting a clinically relevant difference between active treatment and placebo at that center.

Dealing with missing data: Different strategies such as ?Missing Not At Random?, ?Missing At Random? will be employed. The best strategy will be chosen based on statistical measures such as p-values.

Detecting outliers:  To detect an outlier, we have to define what is normal?. The normal may be defined as 11 <  final HAMD < 20. There can be other information about what is normal.  We know older people should recover slower than younger people. If a clinic shows otherwise results, its data may be questionable. We can assign probabilities based on few more tests like this. If the data fails all the tests, or fails half of them or passes all of them.

Machine learning: Use standard machine learning techniques to identify and learn patterns. To classify each centre directly by  plotting the HAMD scores of all patients for each centre. Uninformative and informative centres may exhibit different distributions."
  ["project_timeline"]=>
  string(352) "Anticipated project start date: After we get the data from YODA Project

Analysis completion date: 4 or 5 months after we get the data

Date manuscript drafted: 6 months after we get the data

First submitted for publication: 8 months after we get the data

Date results reported back to YODA Project: 8 months after we get the data"
  ["project_dissemination_plan"]=>
  string(143) "Results of the study will be made available through publication in a peer-reviewed journal or presentation at a relevant scientific conference."
  ["project_bibliography"]=>
  string(660) "
1. Clin Pharmacol Ther. 2008 Sep;84(3):378-84. doi: 10.1038. Model-based approach and signal detection theory to evaluate the performance of recruitment centers in clinical trials with antidepressant drugs. Merlo-Pich E(1), Gomeni R.

2. Neuropsychopharmacology. 2015 Apr 21. doi: 10.1038. A Novel Methodology to Estimate the Treatment Effect in Presence of Highly Variable Placebo Response. Gomeni R(1), Goyal N(2), Bressolle F(1), Fava M(3).

3. Eur J Pharm Sci. 2009 Jan 31;36(1):4-10. doi: 10.1016. Modelling placebo response in depression trials using a longitudinal model with informative dropout. Gomeni R(1), Lavergne A, Merlo-Pich E.
"
  ["project_suppl_material"]=>
  bool(false)
  ["project_coi"]=>
  array(1) {
    [0]=>
    array(1) {
      ["file_coi"]=>
      bool(false)
    }
  }
  ["data_use_agreement_training"]=>
  bool(true)
  ["certification"]=>
  bool(true)
  ["project_send_email_updates"]=>
  bool(true)
  ["project_status"]=>
  string(16) "withdrawn_closed"
  ["project_publ_available"]=>
  bool(true)
  ["project_year_access"]=>
  string(0) ""
  ["project_rep_publ"]=>
  array(1) {
    [0]=>
    array(1) {
      ["publication_link"]=>
      array(3) {
        ["title"]=>
        string(106) "*Request withdrawn prior to approval determination: revisions to proposal requested, but never resubmitted"
        ["url"]=>
        string(106) "*Request withdrawn prior to approval determination: revisions to proposal requested, but never resubmitted"
        ["target"]=>
        string(6) "_blank"
      }
    }
  }
  ["project_assoc_data"]=>
  array(0) {
  }
  ["project_due_dil_assessment"]=>
  bool(false)
  ["project_title_link"]=>
  bool(false)
  ["project_review_link"]=>
  bool(false)
  ["project_highlight_button"]=>
  string(0) ""
  ["search_order"]=>
  string(5) "-6620"
}
data partner
array(1) {
  [0]=>
  string(15) "johnson-johnson"
}


pi country
array(1) {
  [0]=>
  string(9) "Singapore"
}


pi affil
array(1) {
  [0]=>
  string(8) "Industry"
}


products
array(6) {
  [0]=>
  string(8) "concerta"
  [1]=>
  string(6) "invega"
  [2]=>
  string(15) "invega-sustenna"
  [3]=>
  string(16) "risperdal-consta"
  [4]=>
  string(9) "risperdal"
  [5]=>
  string(8) "razadyne"
}


num of trials
array(1) {
  [0]=>
  string(2) "37"
}


res
array(1) {
  [0]=>
  string(1) "3"
}