array(44) {
  ["project_title"]=>
  string(124) "Temporal trajectories of side-effects associated with antipsychotic treatment ? An individual participant data meta-analysis"
  ["project_narrative_summary"]=>
  string(693) "Antipsychotics are the mainstem for the treatment of schizophrenia and other mental disorder. While use of antipsychotics is essential for favorable outcomes in terms of acute efficacy and relapse prevention, it can cause various unpleasant side effects (1). These side effects are associated with a lower quality of life and poorer adherence in patients (2). It is known that patients acquire tolerance to some side effects in clinical practice whereas others may get more severe over time. However, the temporal trajectories of side effects are yet unclear. Therefore, we will investigate temporal trajectories (e.g., onset, duration) of side effects associated with antipsychotic treatment."
  ["project_learn_source"]=>
  string(9) "colleague"
  ["project_learn_source_exp"]=>
  string(0) ""
  ["project_key_personnel"]=>
  array(4) {
    [0]=>
    array(6) {
      ["p_pers_f_name"]=>
      string(8) "Nobuyuki"
      ["p_pers_l_name"]=>
      string(6) "Nomura"
      ["p_pers_degree"]=>
      string(2) "MD"
      ["p_pers_pr_affil"]=>
      string(102) "Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universita?t Mu?nchen"
      ["p_pers_scop_id"]=>
      string(11) "57217203345"
      ["requires_data_access"]=>
      string(0) ""
    }
    [1]=>
    array(6) {
      ["p_pers_f_name"]=>
      string(8) "Johannes"
      ["p_pers_l_name"]=>
      string(15) "Schneider-Thoma"
      ["p_pers_degree"]=>
      string(2) "MD"
      ["p_pers_pr_affil"]=>
      string(102) "Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universita?t Mu?nchen"
      ["p_pers_scop_id"]=>
      string(11) "57194640553"
      ["requires_data_access"]=>
      string(0) ""
    }
    [2]=>
    array(6) {
      ["p_pers_f_name"]=>
      string(8) "Spyridon"
      ["p_pers_l_name"]=>
      string(6) "Siafis"
      ["p_pers_degree"]=>
      string(4) "M.D."
      ["p_pers_pr_affil"]=>
      string(102) "Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universita?t Mu?nchen"
      ["p_pers_scop_id"]=>
      string(11) "57191500943"
      ["requires_data_access"]=>
      string(0) ""
    }
    [3]=>
    array(6) {
      ["p_pers_f_name"]=>
      string(9) "Hiroyoshi"
      ["p_pers_l_name"]=>
      string(8) "Takeuchi"
      ["p_pers_degree"]=>
      string(10) "M.D. Ph.D."
      ["p_pers_pr_affil"]=>
      string(65) "Department of Neuropsychiatry, Keio University School of Medicine"
      ["p_pers_scop_id"]=>
      string(11) "24802425500"
      ["requires_data_access"]=>
      string(0) ""
    }
  }
  ["project_ext_grants"]=>
  array(2) {
    ["value"]=>
    string(2) "no"
    ["label"]=>
    string(68) "No external grants or funds are being used to support this research."
  }
  ["project_funding_source"]=>
  string(0) ""
  ["project_assoc_trials"]=>
  array(100) {
    [0]=>
    object(WP_Post)#3885 (24) {
      ["ID"]=>
      int(1147)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 11:08:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 11:08:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(198) "NCT00488319 - A 2-Year, Open-Label, Single-Arm Safety Study of Flexibly Dosed Paliperidone Extended Release (1.5-12 mg/day) in the Treatment of Adolescents (12 to 17 Years of Age) With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(190) "nct00488319-a-2-year-open-label-single-arm-safety-study-of-flexibly-dosed-paliperidone-extended-release-1-5-12-mg-day-in-the-treatment-of-adolescents-12-to-17-years-of-age-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:12:53"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:12:53"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(239) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00488319-a-2-year-open-label-single-arm-safety-study-of-flexibly-dosed-paliperidone-extended-release-1-5-12-mg-day-in-the-treatment-of-adolescents-12-to-17-years-of-age-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [1]=>
    object(WP_Post)#3886 (24) {
      ["ID"]=>
      int(1156)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 12:21:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 12:21:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(263) "NCT01009047 - A Randomized, Multicenter, Double-Blind, Active-Controlled, Flexible-Dose, Parallel-Group Study of the Efficacy and Safety of Prolonged Release Paliperidone for the Treatment of Symptoms of Schizophrenia in Adolescent Subjects, 12 to 17 Years of Age"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(193) "nct01009047-a-randomized-multicenter-double-blind-active-controlled-flexible-dose-parallel-group-study-of-the-efficacy-and-safety-of-prolonged-release-paliperidone-for-the-treatment-of-symptoms"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:13:06"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:13:06"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(242) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01009047-a-randomized-multicenter-double-blind-active-controlled-flexible-dose-parallel-group-study-of-the-efficacy-and-safety-of-prolonged-release-paliperidone-for-the-treatment-of-symptoms/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [2]=>
    object(WP_Post)#3887 (24) {
      ["ID"]=>
      int(1159)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 12:23:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 12:23:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(170) "NCT00645099 - A Prospective Randomized Open-label 6-Month Head-To-Head Trial to Compare Metabolic Effects of Paliperidone ER and Olanzapine in Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(168) "nct00645099-a-prospective-randomized-open-label-6-month-head-to-head-trial-to-compare-metabolic-effects-of-paliperidone-er-and-olanzapine-in-subjects-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-05-02 09:38:41"
      ["post_modified_gmt"]=>
      string(19) "2024-05-02 13:38:41"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(217) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00645099-a-prospective-randomized-open-label-6-month-head-to-head-trial-to-compare-metabolic-effects-of-paliperidone-er-and-olanzapine-in-subjects-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [3]=>
    object(WP_Post)#3888 (24) {
      ["ID"]=>
      int(1162)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 12:29:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 12:29:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(262) "NCT00518323 - A Randomized, Multicenter, Double-Blind, Weight-Based, Fixed-Dose, Parallel-Group, Placebo-Controlled Study of the Efficacy and Safety of Extended Release Paliperidone for the Treatment of Schizophrenia in Adolescent Subjects, 12 to 17 Years of Age"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(191) "nct00518323-a-randomized-multicenter-double-blind-weight-based-fixed-dose-parallel-group-placebo-controlled-study-of-the-efficacy-and-safety-of-extended-release-paliperidone-for-the-treatment"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-03-26 11:54:17"
      ["post_modified_gmt"]=>
      string(19) "2024-03-26 15:54:17"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(240) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00518323-a-randomized-multicenter-double-blind-weight-based-fixed-dose-parallel-group-placebo-controlled-study-of-the-efficacy-and-safety-of-extended-release-paliperidone-for-the-treatment/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [4]=>
    object(WP_Post)#3889 (24) {
      ["ID"]=>
      int(1165)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 14:23:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 14:23:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(198) "NCT01606228 - An Open-Label Prospective Trial to Explore the Tolerability, Safety and Efficacy of Flexibly-Dosed Paliperidone ER among Treatment-Naive and Newly Diagnosed Patients with Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(195) "nct01606228-an-open-label-prospective-trial-to-explore-the-tolerability-safety-and-efficacy-of-flexibly-dosed-paliperidone-er-among-treatment-naive-and-newly-diagnosed-patients-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:13:15"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:13:15"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(244) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01606228-an-open-label-prospective-trial-to-explore-the-tolerability-safety-and-efficacy-of-flexibly-dosed-paliperidone-er-among-treatment-naive-and-newly-diagnosed-patients-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [5]=>
    object(WP_Post)#3890 (24) {
      ["ID"]=>
      int(1166)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 14:26:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 14:26:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(216) "NCT00334126 - A Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Paliperidone ER Compared to Quetiapine in Subjects With an Acute Exacerbation of Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(194) "nct00334126-a-randomized-double-blind-placebo-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-paliperidone-er-compared-to-quetiapine-in-subjects-with-an-acute-exacerbation"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:13:19"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:13:19"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(243) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00334126-a-randomized-double-blind-placebo-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-paliperidone-er-compared-to-quetiapine-in-subjects-with-an-acute-exacerbation/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [6]=>
    object(WP_Post)#3891 (24) {
      ["ID"]=>
      int(1169)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 14:30:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 14:30:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(223) "NCT00086320 - A Randomized, Double-blind, Placebo-controlled, Parallel-group Study With an Open-label Extension Evaluating Paliperidone Extended Release Tablets in the Prevention of Recurrence in Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(195) "nct00086320-a-randomized-double-blind-placebo-controlled-parallel-group-study-with-an-open-label-extension-evaluating-paliperidone-extended-release-tablets-in-the-prevention-of-recurrence-in-subj"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:13:23"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:13:23"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(244) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00086320-a-randomized-double-blind-placebo-controlled-parallel-group-study-with-an-open-label-extension-evaluating-paliperidone-extended-release-tablets-in-the-prevention-of-recurrence-in-subj/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [7]=>
    object(WP_Post)#3892 (24) {
      ["ID"]=>
      int(1175)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 14:35:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 14:35:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(220) "NCT00589914 - A Randomized, Double-Blind, Parallel-Group, Comparative Study of Flexible Doses of Paliperidone Palmitate and Flexible Doses of Risperidone Long-Acting Intramuscular Injection in Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(195) "nct00589914-a-randomized-double-blind-parallel-group-comparative-study-of-flexible-doses-of-paliperidone-palmitate-and-flexible-doses-of-risperidone-long-acting-intramuscular-injection-in-subject"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-03-25 17:30:56"
      ["post_modified_gmt"]=>
      string(19) "2024-03-25 21:30:56"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(244) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00589914-a-randomized-double-blind-parallel-group-comparative-study-of-flexible-doses-of-paliperidone-palmitate-and-flexible-doses-of-risperidone-long-acting-intramuscular-injection-in-subject/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [8]=>
    object(WP_Post)#3893 (24) {
      ["ID"]=>
      int(1178)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-22 14:37:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-22 14:37:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(191) "NCT00604279 - A Randomized, Open-Label, Parallel Group Comparative Study of Paliperidone Palmitate (50, 100, 150 mg eq) and Risperidone LAI (25, 37.5, or 50 mg) in Subjects with Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(179) "nct00604279-a-randomized-open-label-parallel-group-comparative-study-of-paliperidone-palmitate-50-100-150-mg-eq-and-risperidone-lai-25-37-5-or-50-mg-in-subjects-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:13:37"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:13:37"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(228) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00604279-a-randomized-open-label-parallel-group-comparative-study-of-paliperidone-palmitate-50-100-150-mg-eq-and-risperidone-lai-25-37-5-or-50-mg-in-subjects-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [9]=>
    object(WP_Post)#3894 (24) {
      ["ID"]=>
      int(1181)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:13:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:13:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(247) "NCT00590577 - A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose Response Study to Evaluate the Efficacy and Safety of 3 Fixed Doses (25 mg eq., 100 mg eq., and 150 mg eq.) of Paliperidone Palmitate in Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(187) "nct00590577-a-randomized-double-blind-placebo-controlled-parallel-group-dose-response-study-to-evaluate-the-efficacy-and-safety-of-3-fixed-doses-25-mg-eq-100-mg-eq-and-150-mg-eq-of-palipe"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:13:42"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:13:42"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(236) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00590577-a-randomized-double-blind-placebo-controlled-parallel-group-dose-response-study-to-evaluate-the-efficacy-and-safety-of-3-fixed-doses-25-mg-eq-100-mg-eq-and-150-mg-eq-of-palipe/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [10]=>
    object(WP_Post)#3895 (24) {
      ["ID"]=>
      int(1184)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:22:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:22:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(244) "NCT00111189 - A Randomized Double-blind Placebo-controlled Parallel Group Study Evaluating Paliperidone Palmitate in the Prevention of Recurrence in Patients With Schizophrenia. Placebo Consists of 20% Intralipid (200 mg/mL) Injectable Emulsion"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(197) "nct00111189-a-randomized-double-blind-placebo-controlled-parallel-group-study-evaluating-paliperidone-palmitate-in-the-prevention-of-recurrence-in-patients-with-schizophrenia-placebo-consists-of-20"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-03-26 10:14:14"
      ["post_modified_gmt"]=>
      string(19) "2024-03-26 14:14:14"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(246) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00111189-a-randomized-double-blind-placebo-controlled-parallel-group-study-evaluating-paliperidone-palmitate-in-the-prevention-of-recurrence-in-patients-with-schizophrenia-placebo-consists-of-20/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [11]=>
    object(WP_Post)#3896 (24) {
      ["ID"]=>
      int(1187)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:26:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:26:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(286) "NCT00210717 - A Randomized, Double-Blind, Parallel Group, Comparative Study of Flexibly Dosed Paliperidone Palmitate (25, 50, 75, or 100 mg eq.) Administered Every 4 Weeks and Flexibly Dosed RISPERDAL CONSTA (25, 37.5, or 50 mg) Administered Every 2 Weeks in Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(189) "nct00210717-a-randomized-double-blind-parallel-group-comparative-study-of-flexibly-dosed-paliperidone-palmitate-25-50-75-or-100-mg-eq-administered-every-4-weeks-and-flexibly-dosed-risperdal"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-06-17 15:59:28"
      ["post_modified_gmt"]=>
      string(19) "2024-06-17 19:59:28"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(238) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00210717-a-randomized-double-blind-parallel-group-comparative-study-of-flexibly-dosed-paliperidone-palmitate-25-50-75-or-100-mg-eq-administered-every-4-weeks-and-flexibly-dosed-risperdal/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [12]=>
    object(WP_Post)#3897 (24) {
      ["ID"]=>
      int(1190)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:29:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:29:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(190) "NCT00119756 - A Randomized, Crossover Study to Evaluate the Overall Safety and Tolerability of Paliperidone Palmitate Injected in the Deltoid or Gluteus Muscle in Patients With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(187) "nct00119756-a-randomized-crossover-study-to-evaluate-the-overall-safety-and-tolerability-of-paliperidone-palmitate-injected-in-the-deltoid-or-gluteus-muscle-in-patients-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:13:56"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:13:56"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(236) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00119756-a-randomized-crossover-study-to-evaluate-the-overall-safety-and-tolerability-of-paliperidone-palmitate-injected-in-the-deltoid-or-gluteus-muscle-in-patients-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [13]=>
    object(WP_Post)#3898 (24) {
      ["ID"]=>
      int(1193)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:33:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:33:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(247) "NCT00210548 - A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Response Study to Evaluate the Efficacy and Safety of 3 Fixed Doses (50 mg eq., 100 mg eq., and 150 mg eq.) of Paliperidone Palmitate in Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(187) "nct00210548-a-randomized-double-blind-placebo-controlled-parallel-group-dose-response-study-to-evaluate-the-efficacy-and-safety-of-3-fixed-doses-50-mg-eq-100-mg-eq-and-150-mg-eq-of-palipe"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-03-26 10:15:28"
      ["post_modified_gmt"]=>
      string(19) "2024-03-26 14:15:28"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(236) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00210548-a-randomized-double-blind-placebo-controlled-parallel-group-dose-response-study-to-evaluate-the-efficacy-and-safety-of-3-fixed-doses-50-mg-eq-100-mg-eq-and-150-mg-eq-of-palipe/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [14]=>
    object(WP_Post)#3899 (24) {
      ["ID"]=>
      int(1196)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:35:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:35:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(243) "NCT00101634 - A Randomized, Double-blind, Placebo-controlled, Parallel-group, Dose-response Study to Evaluate the Efficacy and Safety of 3 Fixed Doses (25 mg eq, 50 mg eq, and 100 mg eq) of Paliperidone Palmitate in Patients With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(190) "nct00101634-a-randomized-double-blind-placebo-controlled-parallel-group-dose-response-study-to-evaluate-the-efficacy-and-safety-of-3-fixed-doses-25-mg-eq-50-mg-eq-and-100-mg-eq-of-paliperido"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:04"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:04"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(239) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00101634-a-randomized-double-blind-placebo-controlled-parallel-group-dose-response-study-to-evaluate-the-efficacy-and-safety-of-3-fixed-doses-25-mg-eq-50-mg-eq-and-100-mg-eq-of-paliperido/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [15]=>
    object(WP_Post)#3900 (24) {
      ["ID"]=>
      int(1199)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:40:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:40:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(261) "NCT00391222 - A Randomized, Double Blind, Placebo and Active Controlled Parallel Group Study to Evaluate the Efficacy and Safety of Risperidone Long-acting Injectable (LAI) for the Prevention of Mood Episodes in the Treatment of Subjects With Bipolar I Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(193) "nct00391222-a-randomized-double-blind-placebo-and-active-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-risperidone-long-acting-injectable-lai-for-the-prevention-of-mood"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:10"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:10"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(242) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00391222-a-randomized-double-blind-placebo-and-active-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-risperidone-long-acting-injectable-lai-for-the-prevention-of-mood/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [16]=>
    object(WP_Post)#3901 (24) {
      ["ID"]=>
      int(1202)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:43:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:43:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(134) "NCT00034749 - The Efficacy and Safety of Risperidone in Adolescents With Schizophrenia: a Comparison of Two Dose Ranges of Risperidone"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(131) "nct00034749-the-efficacy-and-safety-of-risperidone-in-adolescents-with-schizophrenia-a-comparison-of-two-dose-ranges-of-risperidone"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:14"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:14"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(180) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00034749-the-efficacy-and-safety-of-risperidone-in-adolescents-with-schizophrenia-a-comparison-of-two-dose-ranges-of-risperidone/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [17]=>
    object(WP_Post)#3902 (24) {
      ["ID"]=>
      int(1205)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:45:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:45:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(265) "NCT00076115 - Research on the Effectiveness of Risperidone in Bipolar Disorder in Adolescents and Children (REACH): A Double-Blind, Randomized, Placebo-Controlled Study of the Efficacy and Safety of Risperidone for the Treatment of Acute Mania in Bipolar I Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(193) "nct00076115-research-on-the-effectiveness-of-risperidone-in-bipolar-disorder-in-adolescents-and-children-reach-a-double-blind-randomized-placebo-controlled-study-of-the-efficacy-and-safety-of-r"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:18"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:18"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(242) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00076115-research-on-the-effectiveness-of-risperidone-in-bipolar-disorder-in-adolescents-and-children-reach-a-double-blind-randomized-placebo-controlled-study-of-the-efficacy-and-safety-of-r/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [18]=>
    object(WP_Post)#3673 (24) {
      ["ID"]=>
      int(1208)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:47:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:47:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(237) "NCT00132678 - A Randomized, Double-blind, Placebo-controlled Study to Explore the Efficacy and Safety of Risperidone Long-acting Intramuscular Injectable in the Prevention of Mood Episodes in Bipolar 1 Disorder, With Open-label Extension"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(195) "nct00132678-a-randomized-double-blind-placebo-controlled-study-to-explore-the-efficacy-and-safety-of-risperidone-long-acting-intramuscular-injectable-in-the-prevention-of-mood-episodes-in-bipolar"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:23"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:23"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(244) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00132678-a-randomized-double-blind-placebo-controlled-study-to-explore-the-efficacy-and-safety-of-risperidone-long-acting-intramuscular-injectable-in-the-prevention-of-mood-episodes-in-bipolar/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [19]=>
    object(WP_Post)#3678 (24) {
      ["ID"]=>
      int(1211)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-09-25 11:50:00"
      ["post_date_gmt"]=>
      string(19) "2014-09-25 11:50:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(205) "NCT00094926 - A Prospective, Randomized, Double-blind, Placebo-controlled Study of the Effectiveness and Safety of RISPERDAL CONSTA Augmentation in Adult Patients With Frequently-relapsing Bipolar Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(195) "nct00094926-a-prospective-randomized-double-blind-placebo-controlled-study-of-the-effectiveness-and-safety-of-risperdal-consta-augmentation-in-adult-patients-with-frequently-relapsing-bipolar-dis"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:27"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:27"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(244) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00094926-a-prospective-randomized-double-blind-placebo-controlled-study-of-the-effectiveness-and-safety-of-risperdal-consta-augmentation-in-adult-patients-with-frequently-relapsing-bipolar-dis/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [20]=>
    object(WP_Post)#3784 (24) {
      ["ID"]=>
      int(1227)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-10-20 14:30:00"
      ["post_date_gmt"]=>
      string(19) "2014-10-20 14:30:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(211) "NCT00397033 - A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy and Safety of Two Dosages of Paliperidone ER in the Treatment of Patients With Schizoaffective Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(195) "nct00397033-a-randomized-double-blind-placebo-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-two-dosages-of-paliperidone-er-in-the-treatment-of-patients-with-schizoaffecti"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:48"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:48"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(244) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00397033-a-randomized-double-blind-placebo-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-two-dosages-of-paliperidone-er-in-the-treatment-of-patients-with-schizoaffecti/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [21]=>
    object(WP_Post)#4940 (24) {
      ["ID"]=>
      int(1230)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-10-20 14:32:00"
      ["post_date_gmt"]=>
      string(19) "2014-10-20 14:32:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(211) "NCT00412373 - A Randomized, Double-blind, Placebo-controlled, Parallel- Group Study to Evaluate the Efficacy and Safety of Flexible-dose Paliperidone ER in the Treatment of Patients With Schizoaffective Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(194) "nct00412373-a-randomized-double-blind-placebo-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-flexible-dose-paliperidone-er-in-the-treatment-of-patients-with-schizoaffecti"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:52"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:52"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(243) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00412373-a-randomized-double-blind-placebo-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-flexible-dose-paliperidone-er-in-the-treatment-of-patients-with-schizoaffecti/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [22]=>
    object(WP_Post)#4939 (24) {
      ["ID"]=>
      int(1233)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-10-20 14:34:00"
      ["post_date_gmt"]=>
      string(19) "2014-10-20 14:34:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(189) "NCT00236444 - Risperidone in the Prevention of Relapse: a Randomized, Double-blind, Placebo-controlled Trial in Children and Adolescents With Conduct and Other Disruptive Behavior Disorders"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(184) "nct00236444-risperidone-in-the-prevention-of-relapse-a-randomized-double-blind-placebo-controlled-trial-in-children-and-adolescents-with-conduct-and-other-disruptive-behavior-disorders"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:14:57"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:14:57"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(233) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00236444-risperidone-in-the-prevention-of-relapse-a-randomized-double-blind-placebo-controlled-trial-in-children-and-adolescents-with-conduct-and-other-disruptive-behavior-disorders/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [23]=>
    object(WP_Post)#4938 (24) {
      ["ID"]=>
      int(1236)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-10-20 14:42:00"
      ["post_date_gmt"]=>
      string(19) "2014-10-20 14:42:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(167) "NCT00236470 - Risperidone in the Treatment of Children and Adolescents With Conduct and Other Disruptive Behavior Disorders - an Open Label Follow-up Trial of CR002020"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(163) "nct00236470-risperidone-in-the-treatment-of-children-and-adolescents-with-conduct-and-other-disruptive-behavior-disorders-an-open-label-follow-up-trial-of-cr002020"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:15:01"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:15:01"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(212) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00236470-risperidone-in-the-treatment-of-children-and-adolescents-with-conduct-and-other-disruptive-behavior-disorders-an-open-label-follow-up-trial-of-cr002020/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [24]=>
    object(WP_Post)#4937 (24) {
      ["ID"]=>
      int(1239)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-10-20 14:45:00"
      ["post_date_gmt"]=>
      string(19) "2014-10-20 14:45:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(166) "NCT00250354 - The Safety And Efficacy Of Risperidone Versus Placebo In Conduct Disorder In Mild, Moderate And Borderline Mentally Retarded Children Aged 5 To 12 Years"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(163) "nct00250354-the-safety-and-efficacy-of-risperidone-versus-placebo-in-conduct-disorder-in-mild-moderate-and-borderline-mentally-retarded-children-aged-5-to-12-years"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:15:04"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:15:04"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(212) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00250354-the-safety-and-efficacy-of-risperidone-versus-placebo-in-conduct-disorder-in-mild-moderate-and-borderline-mentally-retarded-children-aged-5-to-12-years/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [25]=>
    object(WP_Post)#4936 (24) {
      ["ID"]=>
      int(1241)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2014-10-20 14:47:00"
      ["post_date_gmt"]=>
      string(19) "2014-10-20 14:47:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(206) "NCT00266552 - The Safety And Efficacy Of Risperidone Versus Placebo In Conduct Disorder and Other Disruptive Behavior Disorders In Mild, Moderate And Borderline Mentally Retarded Children Aged 5 To 12 Years"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(197) "nct00266552-the-safety-and-efficacy-of-risperidone-versus-placebo-in-conduct-disorder-and-other-disruptive-behavior-disorders-in-mild-moderate-and-borderline-mentally-retarded-children-aged-5-to-12"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:15:06"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:15:06"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(246) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00266552-the-safety-and-efficacy-of-risperidone-versus-placebo-in-conduct-disorder-and-other-disruptive-behavior-disorders-in-mild-moderate-and-borderline-mentally-retarded-children-aged-5-to-12/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [26]=>
    object(WP_Post)#4935 (24) {
      ["ID"]=>
      int(1356)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-07-16 10:24:00"
      ["post_date_gmt"]=>
      string(19) "2015-07-16 10:24:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(158) "NCT00249132 - A Canadian multicenter placebo-controlled study of fixed doses of risperidone and haloperidol in the treatment of chronic schizophrenic patients"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(156) "nct00249132-a-canadian-multicenter-placebo-controlled-study-of-fixed-doses-of-risperidone-and-haloperidol-in-the-treatment-of-chronic-schizophrenic-patients"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-04-24 10:08:05"
      ["post_modified_gmt"]=>
      string(19) "2024-04-24 14:08:05"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(205) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00249132-a-canadian-multicenter-placebo-controlled-study-of-fixed-doses-of-risperidone-and-haloperidol-in-the-treatment-of-chronic-schizophrenic-patients/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [27]=>
    object(WP_Post)#4934 (24) {
      ["ID"]=>
      int(1368)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-08-03 08:35:00"
      ["post_date_gmt"]=>
      string(19) "2015-08-03 08:35:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(91) "NCT00216476 - CONSTATRE: Risperdal® Consta® Trial of Relapse Prevention and Effectiveness"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(84) "nct00216476-constatre-risperdal-consta-trial-of-relapse-prevention-and-effectiveness"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:18:09"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:18:09"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(133) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00216476-constatre-risperdal-consta-trial-of-relapse-prevention-and-effectiveness/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [28]=>
    object(WP_Post)#4933 (24) {
      ["ID"]=>
      int(1371)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-08-03 08:50:00"
      ["post_date_gmt"]=>
      string(19) "2015-08-03 08:50:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(128) "NCT00216580 - An Open-label Trial of Risperidone Long-acting Injectable in the Treatment of Subjects With Recent Onset Psychosis"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(126) "nct00216580-an-open-label-trial-of-risperidone-long-acting-injectable-in-the-treatment-of-subjects-with-recent-onset-psychosis"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:18:14"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:18:14"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(175) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00216580-an-open-label-trial-of-risperidone-long-acting-injectable-in-the-treatment-of-subjects-with-recent-onset-psychosis/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [29]=>
    object(WP_Post)#4932 (24) {
      ["ID"]=>
      int(1374)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-08-10 13:26:00"
      ["post_date_gmt"]=>
      string(19) "2015-08-10 13:26:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(176) "NCT00253162 - The Efficacy And Safety Of Flexible Dose Ranges Of Risperidone Versus Placebo Or Haloperidol In The Treatment Of Manic Episodes Associated With Bipolar I Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(174) "nct00253162-the-efficacy-and-safety-of-flexible-dose-ranges-of-risperidone-versus-placebo-or-haloperidol-in-the-treatment-of-manic-episodes-associated-with-bipolar-i-disorder"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:18:19"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:18:19"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(223) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00253162-the-efficacy-and-safety-of-flexible-dose-ranges-of-risperidone-versus-placebo-or-haloperidol-in-the-treatment-of-manic-episodes-associated-with-bipolar-i-disorder/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [30]=>
    object(WP_Post)#4931 (24) {
      ["ID"]=>
      int(1377)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-09-16 11:36:00"
      ["post_date_gmt"]=>
      string(19) "2015-09-16 11:36:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(140) "NCT00378092 - A Prospective Study of the Clinical Outcome Following Treatment Discontinuation After Remission in First-Episode Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(138) "nct00378092-a-prospective-study-of-the-clinical-outcome-following-treatment-discontinuation-after-remission-in-first-episode-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:18:22"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:18:22"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(187) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00378092-a-prospective-study-of-the-clinical-outcome-following-treatment-discontinuation-after-remission-in-first-episode-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [31]=>
    object(WP_Post)#4930 (24) {
      ["ID"]=>
      int(1380)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-10-20 10:25:00"
      ["post_date_gmt"]=>
      string(19) "2015-10-20 10:25:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(300) "NCT00299715 - A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Response, Multicenter Study to Evaluate the Efficacy and Safety of Three Fixed Doses of Extended-Release Paliperidone in the Treatment of Subjects With Acute Manic and Mixed Episodes Associated With Bipolar I Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(193) "nct00299715-a-randomized-double-blind-placebo-controlled-parallel-group-dose-response-multicenter-study-to-evaluate-the-efficacy-and-safety-of-three-fixed-doses-of-extended-release-paliperidone"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:18:27"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:18:27"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(242) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00299715-a-randomized-double-blind-placebo-controlled-parallel-group-dose-response-multicenter-study-to-evaluate-the-efficacy-and-safety-of-three-fixed-doses-of-extended-release-paliperidone/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [32]=>
    object(WP_Post)#4929 (24) {
      ["ID"]=>
      int(1383)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-10-20 10:28:00"
      ["post_date_gmt"]=>
      string(19) "2015-10-20 10:28:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(330) "NCT00309699 - A Randomized, Double-Blind, Active- and Placebo-Controlled, Parallel-Group, Multicenter Study to Evaluate the Efficacy and Safety of Flexibly-Dosed, Extended-Release Paliperidone Compared With Flexibly-Dosed Quetiapine and Placebo in the Treatment of Acute Manic and Mixed Episodes Associated With Bipolar I Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(192) "nct00309699-a-randomized-double-blind-active-and-placebo-controlled-parallel-group-multicenter-study-to-evaluate-the-efficacy-and-safety-of-flexibly-dosed-extended-release-paliperidone-compare"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:18:32"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:18:32"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(241) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00309699-a-randomized-double-blind-active-and-placebo-controlled-parallel-group-multicenter-study-to-evaluate-the-efficacy-and-safety-of-flexibly-dosed-extended-release-paliperidone-compare/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [33]=>
    object(WP_Post)#4928 (24) {
      ["ID"]=>
      int(1386)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-10-20 10:30:00"
      ["post_date_gmt"]=>
      string(19) "2015-10-20 10:30:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(307) "NCT00309686 - A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study to Evaluate the Efficacy and Safety of Flexibly-Dosed Extended-Release Paliperidone as Adjunctive Therapy to Mood Stabilizers in the Treatment of Acute Manic and Mixed Episodes Associated With Bipolar I Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(194) "nct00309686-a-randomized-double-blind-placebo-controlled-parallel-group-multicenter-study-to-evaluate-the-efficacy-and-safety-of-flexibly-dosed-extended-release-paliperidone-as-adjunctive-therap"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:18:37"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:18:37"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(243) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00309686-a-randomized-double-blind-placebo-controlled-parallel-group-multicenter-study-to-evaluate-the-efficacy-and-safety-of-flexibly-dosed-extended-release-paliperidone-as-adjunctive-therap/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [34]=>
    object(WP_Post)#4927 (24) {
      ["ID"]=>
      int(1389)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-10-20 10:39:00"
      ["post_date_gmt"]=>
      string(19) "2015-10-20 10:39:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(302) "NCT00752427 - 24 week extension of NCT00085748: A Randomized, 6-Week Double-Blind, Placebo-Controlled Study With an Optional 24-Week Open-Label Extension to Evaluate the Safety and Tolerability of Flexible Doses of Paliperidone Extended Release in the Treatment of Geriatric Patients With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(195) "nct00752427-24-week-extension-of-nct00085748-a-randomized-6-week-double-blind-placebo-controlled-study-with-an-optional-24-week-open-label-extension-to-evaluate-the-safety-and-tolerability-of-fle"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-03-26 11:59:03"
      ["post_modified_gmt"]=>
      string(19) "2024-03-26 15:59:03"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(244) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00752427-24-week-extension-of-nct00085748-a-randomized-6-week-double-blind-placebo-controlled-study-with-an-optional-24-week-open-label-extension-to-evaluate-the-safety-and-tolerability-of-fle/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [35]=>
    object(WP_Post)#4926 (24) {
      ["ID"]=>
      int(1392)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-10-20 10:53:00"
      ["post_date_gmt"]=>
      string(19) "2015-10-20 10:53:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(296) "NCT00077714 - A Randomized, Double-blind, Placebo- and Active-controlled, Parallel-group, Dose-response Study to Evaluate the Efficacy and Safety of 2 Fixed Dosages of Paliperidone Extended Release Tablets and Olanzapine, With Open-label Extension, in the Treatment of Patients With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(193) "nct00077714-a-randomized-double-blind-placebo-and-active-controlled-parallel-group-dose-response-study-to-evaluate-the-efficacy-and-safety-of-2-fixed-dosages-of-paliperidone-extended-release-ta"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-04-16 13:30:29"
      ["post_modified_gmt"]=>
      string(19) "2024-04-16 17:30:29"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(242) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00077714-a-randomized-double-blind-placebo-and-active-controlled-parallel-group-dose-response-study-to-evaluate-the-efficacy-and-safety-of-2-fixed-dosages-of-paliperidone-extended-release-ta/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [36]=>
    object(WP_Post)#4925 (24) {
      ["ID"]=>
      int(1395)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-10-20 11:15:00"
      ["post_date_gmt"]=>
      string(19) "2015-10-20 11:15:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(301) "NCT00083668 - A Randomized, Double-blind, Placebo- and Active-controlled, Parallel-group, Dose-response Study to Evaluate the Efficacy and Safety of 3 Fixed Dosages of Paliperidone Extended Release (ER) Tablets and Olanzapine, With Open-label Extension, in the Treatment of Patients With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(192) "nct00083668-a-randomized-double-blind-placebo-and-active-controlled-parallel-group-dose-response-study-to-evaluate-the-efficacy-and-safety-of-3-fixed-dosages-of-paliperidone-extended-release-e"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:18:57"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:18:57"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(241) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00083668-a-randomized-double-blind-placebo-and-active-controlled-parallel-group-dose-response-study-to-evaluate-the-efficacy-and-safety-of-3-fixed-dosages-of-paliperidone-extended-release-e/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [37]=>
    object(WP_Post)#4924 (24) {
      ["ID"]=>
      int(1398)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-10-20 13:11:00"
      ["post_date_gmt"]=>
      string(19) "2015-10-20 13:11:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(179) "NCT00074477 - A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of 50 and 100 Mg-eq of Paliperidone Palmitate in Patients With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(175) "nct00074477-a-randomized-double-blind-placebo-controlled-study-to-evaluate-the-efficacy-and-safety-of-50-and-100-mg-eq-of-paliperidone-palmitate-in-patients-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-03-26 10:16:38"
      ["post_modified_gmt"]=>
      string(19) "2024-03-26 14:16:38"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(224) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00074477-a-randomized-double-blind-placebo-controlled-study-to-evaluate-the-efficacy-and-safety-of-50-and-100-mg-eq-of-paliperidone-palmitate-in-patients-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [38]=>
    object(WP_Post)#4923 (24) {
      ["ID"]=>
      int(1422)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2015-10-27 09:50:00"
      ["post_date_gmt"]=>
      string(19) "2015-10-27 09:50:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(159) "NCT00078039 - Trial Evaluating Three Fixed Dosages of Paliperidone Extended-Release (ER) Tablets and Olanzapine in the Treatment of Patients With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(155) "nct00078039-trial-evaluating-three-fixed-dosages-of-paliperidone-extended-release-er-tablets-and-olanzapine-in-the-treatment-of-patients-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:19:43"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:19:43"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(204) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00078039-trial-evaluating-three-fixed-dosages-of-paliperidone-extended-release-er-tablets-and-olanzapine-in-the-treatment-of-patients-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [39]=>
    object(WP_Post)#4922 (24) {
      ["ID"]=>
      int(1434)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-01-22 08:48:00"
      ["post_date_gmt"]=>
      string(19) "2016-01-22 08:48:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(268) "NCT00085748 - A Randomized, 6-Week Double-Blind, Placebo-Controlled Study With an Optional 24-Week Open-Label Extension to Evaluate the Safety and Tolerability of Flexible Doses of Paliperidone Extended Release in the Treatment of Geriatric Patients With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(196) "nct00085748-a-randomized-6-week-double-blind-placebo-controlled-study-with-an-optional-24-week-open-label-extension-to-evaluate-the-safety-and-tolerability-of-flexible-doses-of-paliperidone-extend"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-03-26 11:56:36"
      ["post_modified_gmt"]=>
      string(19) "2024-03-26 15:56:36"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(245) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00085748-a-randomized-6-week-double-blind-placebo-controlled-study-with-an-optional-24-week-open-label-extension-to-evaluate-the-safety-and-tolerability-of-flexible-doses-of-paliperidone-extend/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [40]=>
    object(WP_Post)#4921 (24) {
      ["ID"]=>
      int(1442)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:10:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:10:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(184) "NCT00249158 - Risperidone in the Treatment of Behavioural and Psychological Signs and Symptoms in Dementia (BPSSD): a Multicentre, Double-blind, Placebo-controlled Parallel-group Trial"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(177) "nct00249158-risperidone-in-the-treatment-of-behavioural-and-psychological-signs-and-symptoms-in-dementia-bpssd-a-multicentre-double-blind-placebo-controlled-parallel-group-trial"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:20:16"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:20:16"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(226) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00249158-risperidone-in-the-treatment-of-behavioural-and-psychological-signs-and-symptoms-in-dementia-bpssd-a-multicentre-double-blind-placebo-controlled-parallel-group-trial/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [41]=>
    object(WP_Post)#4920 (24) {
      ["ID"]=>
      int(1445)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:14:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:14:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(135) "Risperidone in the treatment of behavioural disturbances in patients with Alzheimer's dementia: a double-blind placebo-controlled trial"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(133) "risperidone-in-the-treatment-of-behavioural-disturbances-in-patients-with-alzheimers-dementia-a-double-blind-placebo-controlled-trial"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:20:19"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:20:19"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(182) "https://dev-yoda.pantheonsite.io/clinical-trial/risperidone-in-the-treatment-of-behavioural-disturbances-in-patients-with-alzheimers-dementia-a-double-blind-placebo-controlled-trial/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [42]=>
    object(WP_Post)#4919 (24) {
      ["ID"]=>
      int(1447)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:20:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:20:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(209) "NCT00261508 - Efficacy And Safety Of Risperidone In The Treatment Of Children With Autistic Disorder And Other Pervasive Developmental Disorders: A Canadian, Multicenter, Double-Blind, Placebo-Controlled Study"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(194) "nct00261508-efficacy-and-safety-of-risperidone-in-the-treatment-of-children-with-autistic-disorder-and-other-pervasive-developmental-disorders-a-canadian-multicenter-double-blind-placebo-control"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:20:24"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:20:24"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(243) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00261508-efficacy-and-safety-of-risperidone-in-the-treatment-of-children-with-autistic-disorder-and-other-pervasive-developmental-disorders-a-canadian-multicenter-double-blind-placebo-control/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [43]=>
    object(WP_Post)#4918 (24) {
      ["ID"]=>
      int(1450)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:22:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:22:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(172) "NCT00249236 - The Efficacy And Safety Of Flexible Dosage Ranges Of Risperidone Versus Placebo In The Treatment Of Manic Or Mixed Episodes Associated With Bipolar I Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(170) "nct00249236-the-efficacy-and-safety-of-flexible-dosage-ranges-of-risperidone-versus-placebo-in-the-treatment-of-manic-or-mixed-episodes-associated-with-bipolar-i-disorder"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:20:28"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:20:28"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(219) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00249236-the-efficacy-and-safety-of-flexible-dosage-ranges-of-risperidone-versus-placebo-in-the-treatment-of-manic-or-mixed-episodes-associated-with-bipolar-i-disorder/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [44]=>
    object(WP_Post)#4917 (24) {
      ["ID"]=>
      int(1453)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:24:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:24:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(217) "NCT00249145 - Risperidone in the Treatment of Behavioral Disturbances in Demented Patients: an International, Multicenter, Placebo-controlled, Double-blind, Parallel-group Trial Using Haloperidol as Internal Reference"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(193) "nct00249145-risperidone-in-the-treatment-of-behavioral-disturbances-in-demented-patients-an-international-multicenter-placebo-controlled-double-blind-parallel-group-trial-using-haloperidol-as-i"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:20:33"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:20:33"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(242) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00249145-risperidone-in-the-treatment-of-behavioral-disturbances-in-demented-patients-an-international-multicenter-placebo-controlled-double-blind-parallel-group-trial-using-haloperidol-as-i/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [45]=>
    object(WP_Post)#4916 (24) {
      ["ID"]=>
      int(1456)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:26:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:26:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(173) "NCT00250367 - The Safety And Efficacy Of Risperdal (Risperidone) Versus Placebo As Add-On Therapy To Mood Stabilizers In The Treatment Of The Manic Phase Of Bipolar Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(169) "nct00250367-the-safety-and-efficacy-of-risperdal-risperidone-versus-placebo-as-add-on-therapy-to-mood-stabilizers-in-the-treatment-of-the-manic-phase-of-bipolar-disorder"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:20:38"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:20:38"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(218) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00250367-the-safety-and-efficacy-of-risperdal-risperidone-versus-placebo-as-add-on-therapy-to-mood-stabilizers-in-the-treatment-of-the-manic-phase-of-bipolar-disorder/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [46]=>
    object(WP_Post)#4915 (24) {
      ["ID"]=>
      int(1459)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:29:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:29:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(182) "Efficacy and safety of a flexible dose of risperidone versus placebo in the treatment of psychosis of Alzheimer’s disease. A double-blind, placebo-controlled, parallel-group study."
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(175) "efficacy-and-safety-of-a-flexible-dose-of-risperidone-versus-placebo-in-the-treatment-of-psychosis-of-alzheimers-disease-a-double-blind-placebo-controlled-parallel-group-study"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:20:40"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:20:40"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(224) "https://dev-yoda.pantheonsite.io/clinical-trial/efficacy-and-safety-of-a-flexible-dose-of-risperidone-versus-placebo-in-the-treatment-of-psychosis-of-alzheimers-disease-a-double-blind-placebo-controlled-parallel-group-study/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [47]=>
    object(WP_Post)#4914 (24) {
      ["ID"]=>
      int(1461)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:30:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:30:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(167) "NCT00088075 - A Randomized, Double-Blind, Placebo-Controlled Clinical Study of the Efficacy and Safety of Risperidone for the Treatment of Schizophrenia in Adolescents"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(163) "nct00088075-a-randomized-double-blind-placebo-controlled-clinical-study-of-the-efficacy-and-safety-of-risperidone-for-the-treatment-of-schizophrenia-in-adolescents"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:20:46"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:20:46"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(212) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00088075-a-randomized-double-blind-placebo-controlled-clinical-study-of-the-efficacy-and-safety-of-risperidone-for-the-treatment-of-schizophrenia-in-adolescents/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [48]=>
    object(WP_Post)#4913 (24) {
      ["ID"]=>
      int(1464)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:32:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:32:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(79) "Risperidone versus haloperidol versus placebo in the treatment of schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(79) "risperidone-versus-haloperidol-versus-placebo-in-the-treatment-of-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:20:50"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:20:50"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(128) "https://dev-yoda.pantheonsite.io/clinical-trial/risperidone-versus-haloperidol-versus-placebo-in-the-treatment-of-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [49]=>
    object(WP_Post)#4912 (24) {
      ["ID"]=>
      int(1467)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:35:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:35:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(192) "NCT00253149 - The Safety And Efficacy Of Risperdal (Risperidone) Versus Placebo Versus Haloperidol As Add-On Therapy To Mood Stabilizers In The Treatment Of The Manic Phase Of Bipolar Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(188) "nct00253149-the-safety-and-efficacy-of-risperdal-risperidone-versus-placebo-versus-haloperidol-as-add-on-therapy-to-mood-stabilizers-in-the-treatment-of-the-manic-phase-of-bipolar-disorder"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:20:54"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:20:54"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(237) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00253149-the-safety-and-efficacy-of-risperdal-risperidone-versus-placebo-versus-haloperidol-as-add-on-therapy-to-mood-stabilizers-in-the-treatment-of-the-manic-phase-of-bipolar-disorder/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [50]=>
    object(WP_Post)#4911 (24) {
      ["ID"]=>
      int(1946)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:36:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:36:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(106) "NCT00253136 - Risperidone Depot (Microspheres) vs. Placebo in the Treatment of Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(103) "nct00253136-risperidone-depot-microspheres-vs-placebo-in-the-treatment-of-subjects-with-schizophrenia-2"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:30:05"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:30:05"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(152) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00253136-risperidone-depot-microspheres-vs-placebo-in-the-treatment-of-subjects-with-schizophrenia-2/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [51]=>
    object(WP_Post)#4910 (24) {
      ["ID"]=>
      int(1470)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:38:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:38:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(106) "A double-blind, placebo-controlled study of risperidone in children and adolescents with autistic disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(105) "a-double-blind-placebo-controlled-study-of-risperidone-in-children-and-adolescents-with-autistic-disorder"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:21:00"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:21:00"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(154) "https://dev-yoda.pantheonsite.io/clinical-trial/a-double-blind-placebo-controlled-study-of-risperidone-in-children-and-adolescents-with-autistic-disorder/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [52]=>
    object(WP_Post)#4909 (24) {
      ["ID"]=>
      int(1473)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:39:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:39:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(135) "NCT00034762 - Efficacy And Safety Of A Flexible Dose Of Risperidone Versus Placebo In The Treatment Of Psychosis Of Alzheimer's Disease"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(132) "nct00034762-efficacy-and-safety-of-a-flexible-dose-of-risperidone-versus-placebo-in-the-treatment-of-psychosis-of-alzheimers-disease"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:21:04"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:21:04"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(181) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00034762-efficacy-and-safety-of-a-flexible-dose-of-risperidone-versus-placebo-in-the-treatment-of-psychosis-of-alzheimers-disease/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [53]=>
    object(WP_Post)#4908 (24) {
      ["ID"]=>
      int(1476)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:41:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:41:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(163) "NCT00257075 - The Efficacy And Safety Of Flexible Dosage Ranges Of Risperidone Versus Placebo In The Treatment Of Manic Episodes Associated With Bipolar I Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(161) "nct00257075-the-efficacy-and-safety-of-flexible-dosage-ranges-of-risperidone-versus-placebo-in-the-treatment-of-manic-episodes-associated-with-bipolar-i-disorder"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:21:08"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:21:08"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(210) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00257075-the-efficacy-and-safety-of-flexible-dosage-ranges-of-risperidone-versus-placebo-in-the-treatment-of-manic-episodes-associated-with-bipolar-i-disorder/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [54]=>
    object(WP_Post)#4907 (24) {
      ["ID"]=>
      int(1479)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:42:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:42:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(174) "The efficacy and safety of flexible dose ranges of risperidone vs. Placebo or divalproex sodium in the treatment of manic or mixed episodes associated with bipolar 1 disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(173) "the-efficacy-and-safety-of-flexible-dose-ranges-of-risperidone-vs-placebo-or-divalproex-sodium-in-the-treatment-of-manic-or-mixed-episodes-associated-with-bipolar-1-disorder"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:21:13"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:21:13"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(222) "https://dev-yoda.pantheonsite.io/clinical-trial/the-efficacy-and-safety-of-flexible-dose-ranges-of-risperidone-vs-placebo-or-divalproex-sodium-in-the-treatment-of-manic-or-mixed-episodes-associated-with-bipolar-1-disorder/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [55]=>
    object(WP_Post)#4906 (24) {
      ["ID"]=>
      int(1482)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:44:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:44:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(148) "NCT00253123 - A Randomized, Double-Blind, Placebo-Controlled Study of Risperidone for Treatment of Behavioral Disturbances in Subjects With Dementia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(144) "nct00253123-a-randomized-double-blind-placebo-controlled-study-of-risperidone-for-treatment-of-behavioral-disturbances-in-subjects-with-dementia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:21:17"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:21:17"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(193) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00253123-a-randomized-double-blind-placebo-controlled-study-of-risperidone-for-treatment-of-behavioral-disturbances-in-subjects-with-dementia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [56]=>
    object(WP_Post)#4905 (24) {
      ["ID"]=>
      int(1485)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:45:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:45:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(112) "The safety and efficacy of risperidone 8 mg qd and 4 mg qd compared to placebo in the treatment of schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(112) "the-safety-and-efficacy-of-risperidone-8-mg-qd-and-4-mg-qd-compared-to-placebo-in-the-treatment-of-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:21:21"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:21:21"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(161) "https://dev-yoda.pantheonsite.io/clinical-trial/the-safety-and-efficacy-of-risperidone-8-mg-qd-and-4-mg-qd-compared-to-placebo-in-the-treatment-of-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [57]=>
    object(WP_Post)#4904 (24) {
      ["ID"]=>
      int(1488)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:47:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:47:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(174) "NCT01529515 - A Randomized, Multicenter, Double-Blind, Relapse Prevention Study of Paliperidone Palmitate 3 Month Formulation for the Treatment of Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(169) "nct01529515-a-randomized-multicenter-double-blind-relapse-prevention-study-of-paliperidone-palmitate-3-month-formulation-for-the-treatment-of-subjects-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-05-02 14:10:46"
      ["post_modified_gmt"]=>
      string(19) "2024-05-02 18:10:46"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(218) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01529515-a-randomized-multicenter-double-blind-relapse-prevention-study-of-paliperidone-palmitate-3-month-formulation-for-the-treatment-of-subjects-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [58]=>
    object(WP_Post)#4903 (24) {
      ["ID"]=>
      int(1491)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:49:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:49:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(177) "NCT01193153 - A Randomized, Double-Blind, Placebo-Controlled, Parellel-Group Study of Paliperidone Palmitate Evaluating Time to Relapse in Subjects With Schizoaffective Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(172) "nct01193153-a-randomized-double-blind-placebo-controlled-parellel-group-study-of-paliperidone-palmitate-evaluating-time-to-relapse-in-subjects-with-schizoaffective-disorder"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-05-07 13:02:18"
      ["post_modified_gmt"]=>
      string(19) "2024-05-07 17:02:18"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(221) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01193153-a-randomized-double-blind-placebo-controlled-parellel-group-study-of-paliperidone-palmitate-evaluating-time-to-relapse-in-subjects-with-schizoaffective-disorder/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [59]=>
    object(WP_Post)#4902 (24) {
      ["ID"]=>
      int(1493)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:50:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:50:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(182) "NCT01662310 - Paliperidone Extended Release Tablets for the Prevention of Relapse in Subjects With Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(176) "nct01662310-paliperidone-extended-release-tablets-for-the-prevention-of-relapse-in-subjects-with-schizophrenia-a-randomized-double-blind-placebo-controlled-parallel-group-study"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-05-02 09:42:20"
      ["post_modified_gmt"]=>
      string(19) "2024-05-02 13:42:20"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(225) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01662310-paliperidone-extended-release-tablets-for-the-prevention-of-relapse-in-subjects-with-schizophrenia-a-randomized-double-blind-placebo-controlled-parallel-group-study/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [60]=>
    object(WP_Post)#4901 (24) {
      ["ID"]=>
      int(1496)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:53:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:53:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(274) "NCT00490971 - A Randomized, Double-Blind, Active- and Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Extended-Release Paliperidone as Maintenance Treatment After an Acute Manic or Mixed Episode Associated With Bipolar I Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(193) "nct00490971-a-randomized-double-blind-active-and-placebo-controlled-parallel-group-multicenter-study-to-evaluate-the-efficacy-and-safety-of-extended-release-paliperidone-as-maintenance-treatmen"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:21:36"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:21:36"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(242) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00490971-a-randomized-double-blind-active-and-placebo-controlled-parallel-group-multicenter-study-to-evaluate-the-efficacy-and-safety-of-extended-release-paliperidone-as-maintenance-treatmen/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [61]=>
    object(WP_Post)#4900 (24) {
      ["ID"]=>
      int(1499)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:54:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:54:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(248) "NCT00524043 - A Randomized, Double-Blind, Placebo- and Active-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of a Fixed Dosage of 1.5 mg/Day of Paliperidone Extended Release (ER) in the Treatment of Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(192) "nct00524043-a-randomized-double-blind-placebo-and-active-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-a-fixed-dosage-of-1-5-mg-day-of-paliperidone-extended-release-er"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:21:41"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:21:41"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(241) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00524043-a-randomized-double-blind-placebo-and-active-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-a-fixed-dosage-of-1-5-mg-day-of-paliperidone-extended-release-er/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [62]=>
    object(WP_Post)#4899 (24) {
      ["ID"]=>
      int(1502)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-03-31 12:56:00"
      ["post_date_gmt"]=>
      string(19) "2016-03-31 12:56:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(182) "NCT00105326 - A Double-blind, Placebo-controlled, Randomized Study Evaluating the Effect of Paliperidone ER Compared With Placebo on Sleep Architecture in Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(178) "nct00105326-a-double-blind-placebo-controlled-randomized-study-evaluating-the-effect-of-paliperidone-er-compared-with-placebo-on-sleep-architecture-in-subjects-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:21:45"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:21:45"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(227) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00105326-a-double-blind-placebo-controlled-randomized-study-evaluating-the-effect-of-paliperidone-er-compared-with-placebo-on-sleep-architecture-in-subjects-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [63]=>
    object(WP_Post)#4898 (24) {
      ["ID"]=>
      int(1507)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-05-09 11:51:00"
      ["post_date_gmt"]=>
      string(19) "2016-05-09 11:51:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(116) "An open-label, long-term study of risperidone for the treatment of behavioral disturbances in patients with dementia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(115) "an-open-label-long-term-study-of-risperidone-for-the-treatment-of-behavioral-disturbances-in-patients-with-dementia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:21:50"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:21:50"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(164) "https://dev-yoda.pantheonsite.io/clinical-trial/an-open-label-long-term-study-of-risperidone-for-the-treatment-of-behavioral-disturbances-in-patients-with-dementia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [64]=>
    object(WP_Post)#4897 (24) {
      ["ID"]=>
      int(1571)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2016-11-02 12:51:00"
      ["post_date_gmt"]=>
      string(19) "2016-11-02 12:51:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(134) "NCT00246246 - A Randomized, Open-label Trial of RISPERDAL® CONSTA™ Versus Oral Antipsychotic Care in Subjects With Bipolar Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(126) "nct00246246-a-randomized-open-label-trial-of-risperdal-consta-versus-oral-antipsychotic-care-in-subjects-with-bipolar-disorder"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:23:20"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:23:20"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(175) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00246246-a-randomized-open-label-trial-of-risperdal-consta-versus-oral-antipsychotic-care-in-subjects-with-bipolar-disorder/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [65]=>
    object(WP_Post)#4896 (24) {
      ["ID"]=>
      int(1604)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2017-08-24 12:58:00"
      ["post_date_gmt"]=>
      string(19) "2017-08-24 12:58:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(204) "NCT00044681 - A Study to Evaluate the Efficacy, Safety and Maintenance Effect of Risperidone Augmentation of SSRI Monotherapy in Young and Older Adult Patients With Unipolar Treatment-Resistant Depression"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(197) "nct00044681-a-study-to-evaluate-the-efficacy-safety-and-maintenance-effect-of-risperidone-augmentation-of-ssri-monotherapy-in-young-and-older-adult-patients-with-unipolar-treatment-resistant-depres"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:24:03"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:24:03"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(246) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00044681-a-study-to-evaluate-the-efficacy-safety-and-maintenance-effect-of-risperidone-augmentation-of-ssri-monotherapy-in-young-and-older-adult-patients-with-unipolar-treatment-resistant-depres/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [66]=>
    object(WP_Post)#4895 (24) {
      ["ID"]=>
      int(1670)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2018-03-08 14:29:00"
      ["post_date_gmt"]=>
      string(19) "2018-03-08 14:29:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(137) "NCT00249223 - Risperidone Depot (Microspheres) vs. Risperidone Tablets - a Non-inferiority, Efficacy Trial in Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(129) "nct00249223-risperidone-depot-microspheres-vs-risperidone-tablets-a-non-inferiority-efficacy-trial-in-subjects-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:25:20"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:25:20"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(178) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00249223-risperidone-depot-microspheres-vs-risperidone-tablets-a-non-inferiority-efficacy-trial-in-subjects-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [67]=>
    object(WP_Post)#4894 (24) {
      ["ID"]=>
      int(1731)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2018-11-27 18:08:00"
      ["post_date_gmt"]=>
      string(19) "2018-11-27 18:08:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(269) "NCT01157351 - A Fifteen-month, Prospective, Randomized, Active-controlled, Open-label, Flexible Dose Study of Paliperidone Palmitate Compared With Oral Antipsychotic Treatment in Delaying Time to Treatment Failure in Adults With Schizophrenia Who Have Been Incarcerated"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(193) "nct01157351-a-fifteen-month-prospective-randomized-active-controlled-open-label-flexible-dose-study-of-paliperidone-palmitate-compared-with-oral-antipsychotic-treatment-in-delaying-time-to-trea"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:26:25"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:26:25"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(242) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01157351-a-fifteen-month-prospective-randomized-active-controlled-open-label-flexible-dose-study-of-paliperidone-palmitate-compared-with-oral-antipsychotic-treatment-in-delaying-time-to-trea/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [68]=>
    object(WP_Post)#4893 (24) {
      ["ID"]=>
      int(1732)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2018-11-27 18:12:00"
      ["post_date_gmt"]=>
      string(19) "2018-11-27 18:12:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(301) "NCT01081769 - A 24-month, Prospective, Randomized, Active-Controlled, Open-Label, Rater-Blinded, Multicenter, International Study of the Prevention of Relapse Comparing Long-Acting Injectable Paliperidone Palmitate to Treatment as Usual With Oral Antipsychotic Monotherapy in Adults With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(191) "nct01081769-a-24-month-prospective-randomized-active-controlled-open-label-rater-blinded-multicenter-international-study-of-the-prevention-of-relapse-comparing-long-acting-injectable-paliperi"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:26:26"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:26:26"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(240) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01081769-a-24-month-prospective-randomized-active-controlled-open-label-rater-blinded-multicenter-international-study-of-the-prevention-of-relapse-comparing-long-acting-injectable-paliperi/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [69]=>
    object(WP_Post)#4892 (24) {
      ["ID"]=>
      int(1733)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2018-11-27 18:17:00"
      ["post_date_gmt"]=>
      string(19) "2018-11-27 18:17:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(268) "NCT01281527 - A 6-month, Open Label, Prospective, Multicenter, International, Exploratory Study of a Transition to Flexibly Dosed Paliperidone Palmitate in Patients With Schizophrenia Previously Unsuccessfully Treated With Oral or Long-acting Injectable Antipsychotics"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(193) "nct01281527-a-6-month-open-label-prospective-multicenter-international-exploratory-study-of-a-transition-to-flexibly-dosed-paliperidone-palmitate-in-patients-with-schizophrenia-previously-unsuc"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-04-17 10:09:50"
      ["post_modified_gmt"]=>
      string(19) "2024-04-17 14:09:50"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(242) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01281527-a-6-month-open-label-prospective-multicenter-international-exploratory-study-of-a-transition-to-flexibly-dosed-paliperidone-palmitate-in-patients-with-schizophrenia-previously-unsuc/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [70]=>
    object(WP_Post)#4891 (24) {
      ["ID"]=>
      int(1735)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2018-11-27 18:30:00"
      ["post_date_gmt"]=>
      string(19) "2018-11-27 18:30:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(155) "NCT01051531 - Safety, Tolerability, and Treatment Response of Paliperidone Palmitate in Subjects With Schizophrenia When Switching From Oral Antipsychotics"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(151) "nct01051531-safety-tolerability-and-treatment-response-of-paliperidone-palmitate-in-subjects-with-schizophrenia-when-switching-from-oral-antipsychotics"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:26:31"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:26:31"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(200) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01051531-safety-tolerability-and-treatment-response-of-paliperidone-palmitate-in-subjects-with-schizophrenia-when-switching-from-oral-antipsychotics/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [71]=>
    object(WP_Post)#4890 (24) {
      ["ID"]=>
      int(1737)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2018-11-27 18:39:00"
      ["post_date_gmt"]=>
      string(19) "2018-11-27 18:39:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(162) "NCT01527305 - An Open-Label, Prospective, Non-Comparative Study to Evaluate the Efficacy and Safety of Paliperidone Palmitate in Subjects With Acute Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(158) "nct01527305-an-open-label-prospective-non-comparative-study-to-evaluate-the-efficacy-and-safety-of-paliperidone-palmitate-in-subjects-with-acute-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:26:33"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:26:33"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(207) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01527305-an-open-label-prospective-non-comparative-study-to-evaluate-the-efficacy-and-safety-of-paliperidone-palmitate-in-subjects-with-acute-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [72]=>
    object(WP_Post)#4889 (24) {
      ["ID"]=>
      int(1739)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2018-11-27 18:46:00"
      ["post_date_gmt"]=>
      string(19) "2018-11-27 18:46:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(173) "NCT01299389 - A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Fixed-Dose, Multicenter Study of JNS010 (Paliperidone Palmitate) in Patients With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(164) "nct01299389-a-randomized-double-blind-placebo-controlled-parallel-group-fixed-dose-multicenter-study-of-jns010-paliperidone-palmitate-in-patients-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:26:37"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:26:37"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(213) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01299389-a-randomized-double-blind-placebo-controlled-parallel-group-fixed-dose-multicenter-study-of-jns010-paliperidone-palmitate-in-patients-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [73]=>
    object(WP_Post)#4888 (24) {
      ["ID"]=>
      int(1741)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2018-11-27 18:49:00"
      ["post_date_gmt"]=>
      string(19) "2018-11-27 18:49:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(160) "NCT01258920 - A Long-Term, Open-Label Study of Flexibly Dosed Paliperidone Palmitate Long-Acting Intramuscular Injection in Japanese Patients With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(157) "nct01258920-a-long-term-open-label-study-of-flexibly-dosed-paliperidone-palmitate-long-acting-intramuscular-injection-in-japanese-patients-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:26:39"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:26:39"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(206) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01258920-a-long-term-open-label-study-of-flexibly-dosed-paliperidone-palmitate-long-acting-intramuscular-injection-in-japanese-patients-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [74]=>
    object(WP_Post)#4887 (24) {
      ["ID"]=>
      int(1752)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2018-12-20 10:14:00"
      ["post_date_gmt"]=>
      string(19) "2018-12-20 10:14:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(131) "NCT00216671 - Early Versus Late Initiation of Treatment With Risperdal Consta in Subjects With Schizophrenia After an Acute Episode"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(129) "nct00216671-early-versus-late-initiation-of-treatment-with-risperdal-consta-in-subjects-with-schizophrenia-after-an-acute-episode"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:26:48"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:26:48"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(178) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00216671-early-versus-late-initiation-of-treatment-with-risperdal-consta-in-subjects-with-schizophrenia-after-an-acute-episode/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [75]=>
    object(WP_Post)#4886 (24) {
      ["ID"]=>
      int(1753)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2018-12-20 10:17:00"
      ["post_date_gmt"]=>
      string(19) "2018-12-20 10:17:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(131) "NCT00369239 - Is Premorbid Functioning a Predictor of Outcome in Patients With Early Onset Psychosis Treated With Risperdal Consta?"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(128) "nct00369239-is-premorbid-functioning-a-predictor-of-outcome-in-patients-with-early-onset-psychosis-treated-with-risperdal-consta"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:26:51"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:26:51"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(177) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00369239-is-premorbid-functioning-a-predictor-of-outcome-in-patients-with-early-onset-psychosis-treated-with-risperdal-consta/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [76]=>
    object(WP_Post)#4885 (24) {
      ["ID"]=>
      int(1755)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2018-12-20 10:22:00"
      ["post_date_gmt"]=>
      string(19) "2018-12-20 10:22:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(133) "NCT00216632 - Treatment Success in Patients Requiring Treatment Change From Olanzapine to Risperidone Long Acting Injectable (TRESOR)"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(129) "nct00216632-treatment-success-in-patients-requiring-treatment-change-from-olanzapine-to-risperidone-long-acting-injectable-tresor"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:26:51"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:26:51"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(178) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00216632-treatment-success-in-patients-requiring-treatment-change-from-olanzapine-to-risperidone-long-acting-injectable-tresor/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [77]=>
    object(WP_Post)#4884 (24) {
      ["ID"]=>
      int(1756)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2018-12-20 10:25:00"
      ["post_date_gmt"]=>
      string(19) "2018-12-20 10:25:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(214) "NCT00236379 - A Six-month, Double-blind, Randomized, International, Multicenter Trial to Evaluate the Glucoregulatory Effects of Risperidone and Olanzapine in Subjects With Schizophrenia or Schizoaffective Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(194) "nct00236379-a-six-month-double-blind-randomized-international-multicenter-trial-to-evaluate-the-glucoregulatory-effects-of-risperidone-and-olanzapine-in-subjects-with-schizophrenia-or-schizoaffe"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:26:55"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:26:55"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(243) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00236379-a-six-month-double-blind-randomized-international-multicenter-trial-to-evaluate-the-glucoregulatory-effects-of-risperidone-and-olanzapine-in-subjects-with-schizophrenia-or-schizoaffe/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [78]=>
    object(WP_Post)#4883 (24) {
      ["ID"]=>
      int(1758)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2018-12-20 10:28:00"
      ["post_date_gmt"]=>
      string(19) "2018-12-20 10:28:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(211) "NCT00576732 - Risperidone in the Treatment of Children and Adolescents With Autistic Disorder: A Double-Blind, Placebo-Controlled Study of Efficacy and Safety, Followed by an Open-Label Extension Study of Safety"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(195) "nct00576732-risperidone-in-the-treatment-of-children-and-adolescents-with-autistic-disorder-a-double-blind-placebo-controlled-study-of-efficacy-and-safety-followed-by-an-open-label-extension-stud"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:26:56"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:26:56"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(244) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00576732-risperidone-in-the-treatment-of-children-and-adolescents-with-autistic-disorder-a-double-blind-placebo-controlled-study-of-efficacy-and-safety-followed-by-an-open-label-extension-stud/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [79]=>
    object(WP_Post)#4882 (24) {
      ["ID"]=>
      int(1759)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2018-12-20 10:30:00"
      ["post_date_gmt"]=>
      string(19) "2018-12-20 10:30:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(159) "NCT01050582 - Evaluation of Growth, Sexual Maturation, and Prolactin-Related Adverse Events in the Pediatric Population Exposed to Atypical Antipsychotic Drugs"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(155) "nct01050582-evaluation-of-growth-sexual-maturation-and-prolactin-related-adverse-events-in-the-pediatric-population-exposed-to-atypical-antipsychotic-drugs"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:26:56"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:26:56"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(204) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01050582-evaluation-of-growth-sexual-maturation-and-prolactin-related-adverse-events-in-the-pediatric-population-exposed-to-atypical-antipsychotic-drugs/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [80]=>
    object(WP_Post)#4881 (24) {
      ["ID"]=>
      int(1760)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2018-12-20 10:32:00"
      ["post_date_gmt"]=>
      string(19) "2018-12-20 10:32:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(210) "NCT00086112 - A Double-blind, Randomized, Prospective Study to Evaluate Adjunctive Risperidone Versus Adjunctive Placebo in Generalized Anxiety Disorder Sub-optimally Responsive to Standard Psychotropic Therapy"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(196) "nct00086112-a-double-blind-randomized-prospective-study-to-evaluate-adjunctive-risperidone-versus-adjunctive-placebo-in-generalized-anxiety-disorder-sub-optimally-responsive-to-standard-psychotrop"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:26:57"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:26:57"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(245) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00086112-a-double-blind-randomized-prospective-study-to-evaluate-adjunctive-risperidone-versus-adjunctive-placebo-in-generalized-anxiety-disorder-sub-optimally-responsive-to-standard-psychotrop/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [81]=>
    object(WP_Post)#4880 (24) {
      ["ID"]=>
      int(1771)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-03-18 09:56:00"
      ["post_date_gmt"]=>
      string(19) "2019-03-18 09:56:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(157) "NCT00216528 - A Prospective, Open-Label Study to Evaluate Symptomatic Remission in Schizophrenia With Long Acting Risperidone Microspheres (Risperdal Consta)"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(152) "nct00216528-a-prospective-open-label-study-to-evaluate-symptomatic-remission-in-schizophrenia-with-long-acting-risperidone-microspheres-risperdal-consta"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:27:09"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:27:09"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(201) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00216528-a-prospective-open-label-study-to-evaluate-symptomatic-remission-in-schizophrenia-with-long-acting-risperidone-microspheres-risperdal-consta/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [82]=>
    object(WP_Post)#4879 (24) {
      ["ID"]=>
      int(1772)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-03-18 10:01:00"
      ["post_date_gmt"]=>
      string(19) "2019-03-18 10:01:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(154) "NCT00269919 - Effect on Efficacy, Safety and Quality of Life by Long-Term Treatment of Long-Acting Risperidone Microspheres in Patients With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(151) "nct00269919-effect-on-efficacy-safety-and-quality-of-life-by-long-term-treatment-of-long-acting-risperidone-microspheres-in-patients-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:27:10"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:27:10"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(200) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00269919-effect-on-efficacy-safety-and-quality-of-life-by-long-term-treatment-of-long-acting-risperidone-microspheres-in-patients-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [83]=>
    object(WP_Post)#4878 (24) {
      ["ID"]=>
      int(1773)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-03-18 10:04:00"
      ["post_date_gmt"]=>
      string(19) "2019-03-18 10:04:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(229) "NCT00992407 - A Randomized, Open-label, Active-controlled Study to Evaluate Social Functioning of Long Acting Injectable Risperidone and Oral Risperidone in the Treatment of Subjects With Schizophrenia or Schizoaffective Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(196) "nct00992407-a-randomized-open-label-active-controlled-study-to-evaluate-social-functioning-of-long-acting-injectable-risperidone-and-oral-risperidone-in-the-treatment-of-subjects-with-schizophreni"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:27:11"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:27:11"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(245) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00992407-a-randomized-open-label-active-controlled-study-to-evaluate-social-functioning-of-long-acting-injectable-risperidone-and-oral-risperidone-in-the-treatment-of-subjects-with-schizophreni/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [84]=>
    object(WP_Post)#4877 (24) {
      ["ID"]=>
      int(1774)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-03-18 10:54:00"
      ["post_date_gmt"]=>
      string(19) "2019-03-18 10:54:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(200) "NCT00236353 - An Open-label Study of the Efficacy and Safety of RISPERDAL Long-acting Microspheres (RISPERDAL CONSTA) Administered Once Monthly in Adults With Schizophrenia or Schizoaffective Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(196) "nct00236353-an-open-label-study-of-the-efficacy-and-safety-of-risperdal-long-acting-microspheres-risperdal-consta-administered-once-monthly-in-adults-with-schizophrenia-or-schizoaffective-disorder"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:27:11"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:27:11"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(245) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00236353-an-open-label-study-of-the-efficacy-and-safety-of-risperdal-long-acting-microspheres-risperdal-consta-administered-once-monthly-in-adults-with-schizophrenia-or-schizoaffective-disorder/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [85]=>
    object(WP_Post)#4876 (24) {
      ["ID"]=>
      int(1775)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-03-18 10:57:00"
      ["post_date_gmt"]=>
      string(19) "2019-03-18 10:57:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(183) "NCT00495118 - Risperidone Depot (Microspheres) in the Treatment of Subjects With Schizophrenia or Schizoaffective Disorder - an Open-label Follow-up Trial of RIS-INT-62 and RIS-INT-85"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(177) "nct00495118-risperidone-depot-microspheres-in-the-treatment-of-subjects-with-schizophrenia-or-schizoaffective-disorder-an-open-label-follow-up-trial-of-ris-int-62-and-ris-int-85"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:27:14"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:27:14"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(226) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00495118-risperidone-depot-microspheres-in-the-treatment-of-subjects-with-schizophrenia-or-schizoaffective-disorder-an-open-label-follow-up-trial-of-ris-int-62-and-ris-int-85/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [86]=>
    object(WP_Post)#4875 (24) {
      ["ID"]=>
      int(1777)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-03-18 11:02:00"
      ["post_date_gmt"]=>
      string(19) "2019-03-18 11:02:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(314) "NCT01855074 - Evaluation of Efficacy and Safety of Risperidone in Long-acting Microspheres in Patients With Schizophrenia, Schizophreniform or Schizoaffective Disorders Diagnosed According to the DSM-IV Criteria, After Switching Treatment With Any Antipsychotic Therapy With Long-acting Microspheres of Risperidone"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(196) "nct01855074-evaluation-of-efficacy-and-safety-of-risperidone-in-long-acting-microspheres-in-patients-with-schizophrenia-schizophreniform-or-schizoaffective-disorders-diagnosed-according-to-the-dsm"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:27:15"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:27:15"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(245) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01855074-evaluation-of-efficacy-and-safety-of-risperidone-in-long-acting-microspheres-in-patients-with-schizophrenia-schizophreniform-or-schizoaffective-disorders-diagnosed-according-to-the-dsm/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [87]=>
    object(WP_Post)#4874 (24) {
      ["ID"]=>
      int(1778)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-03-18 11:05:00"
      ["post_date_gmt"]=>
      string(19) "2019-03-18 11:05:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(181) "NCT00236457 - Randomized, Multi-center, Open Label Trial Comparing Risperidone Depot (Microspheres) and Olanzapine Tablets in Patients With Schizophrenia or Schizoaffective Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(175) "nct00236457-randomized-multi-center-open-label-trial-comparing-risperidone-depot-microspheres-and-olanzapine-tablets-in-patients-with-schizophrenia-or-schizoaffective-disorder"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:27:17"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:27:17"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(224) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00236457-randomized-multi-center-open-label-trial-comparing-risperidone-depot-microspheres-and-olanzapine-tablets-in-patients-with-schizophrenia-or-schizoaffective-disorder/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [88]=>
    object(WP_Post)#4873 (24) {
      ["ID"]=>
      int(1780)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-03-18 11:09:00"
      ["post_date_gmt"]=>
      string(19) "2019-03-18 11:09:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(142) "NCT00236587 - An Open Label, Long Term Trial of Risperidone Long Acting Microspheres in the Treatment of Patients Diagnosed With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(139) "nct00236587-an-open-label-long-term-trial-of-risperidone-long-acting-microspheres-in-the-treatment-of-patients-diagnosed-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:27:21"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:27:21"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(188) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00236587-an-open-label-long-term-trial-of-risperidone-long-acting-microspheres-in-the-treatment-of-patients-diagnosed-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [89]=>
    object(WP_Post)#4872 (24) {
      ["ID"]=>
      int(1782)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-03-18 11:24:00"
      ["post_date_gmt"]=>
      string(19) "2019-03-18 11:24:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(308) "NCT00297388 - A 52-wk Prospective, Randomized, Double-blind, Multicenter Study of Relapse Following Transition From Oral Antipsychotic Medication to 2 Different Doses (25 or 50 mg Every 2 Wks) of Risperidone Long-acting Microspheres (RISPERDAL CONSTA) in Adults With Schizophrenia or Schizoaffective Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(193) "nct00297388-a-52-wk-prospective-randomized-double-blind-multicenter-study-of-relapse-following-transition-from-oral-antipsychotic-medication-to-2-different-doses-25-or-50-mg-every-2-wks-of-risp"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:27:21"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:27:21"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(242) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00297388-a-52-wk-prospective-randomized-double-blind-multicenter-study-of-relapse-following-transition-from-oral-antipsychotic-medication-to-2-different-doses-25-or-50-mg-every-2-wks-of-risp/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [90]=>
    object(WP_Post)#4871 (24) {
      ["ID"]=>
      int(1783)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-03-18 11:29:00"
      ["post_date_gmt"]=>
      string(19) "2019-03-18 11:29:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(251) "NCT00821600 - Single-Dose, Open-Label Pilot Study to Explore the Pharmacokinetics, Safety and Tolerability of a Gluteal Intramuscular Injection of a 4-Week Long-Acting Injectable Formulation of Risperidone in Patients With Chronic Stable Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(196) "nct00821600-single-dose-open-label-pilot-study-to-explore-the-pharmacokinetics-safety-and-tolerability-of-a-gluteal-intramuscular-injection-of-a-4-week-long-acting-injectable-formulation-of-risper"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-04-02 10:11:06"
      ["post_modified_gmt"]=>
      string(19) "2024-04-02 14:11:06"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(245) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00821600-single-dose-open-label-pilot-study-to-explore-the-pharmacokinetics-safety-and-tolerability-of-a-gluteal-intramuscular-injection-of-a-4-week-long-acting-injectable-formulation-of-risper/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [91]=>
    object(WP_Post)#4870 (24) {
      ["ID"]=>
      int(1786)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-03-18 11:41:00"
      ["post_date_gmt"]=>
      string(19) "2019-03-18 11:41:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(295) "NCT00526877 - Evaluation of Efficacy and Safety of Long-acting Risperidone Microspheres in Patients With Schizophrenia or Schizoaffective Disorders, Who is Receiving Psychiatric Home-care Treatment, When Switching From Typical Depot or Oral Antipsychotics to Long-acting Risperidone Microspheres"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(196) "nct00526877-evaluation-of-efficacy-and-safety-of-long-acting-risperidone-microspheres-in-patients-with-schizophrenia-or-schizoaffective-disorders-who-is-receiving-psychiatric-home-care-treatment-w"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:27:27"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:27:27"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(245) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00526877-evaluation-of-efficacy-and-safety-of-long-acting-risperidone-microspheres-in-patients-with-schizophrenia-or-schizoaffective-disorders-who-is-receiving-psychiatric-home-care-treatment-w/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [92]=>
    object(WP_Post)#4869 (24) {
      ["ID"]=>
      int(1803)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-07-26 13:45:00"
      ["post_date_gmt"]=>
      string(19) "2019-07-26 13:45:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(216) "NCT00061802 - A Randomized, Double Blind Study to Evaluate the Efficacy and Safety of Two Atypical Antipsychotics vs. Placebo in Patients With an Acute Exacerbation of Either Schizophrenia or Schizoaffective Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(196) "nct00061802-a-randomized-double-blind-study-to-evaluate-the-efficacy-and-safety-of-two-atypical-antipsychotics-vs-placebo-in-patients-with-an-acute-exacerbation-of-either-schizophrenia-or-schizoaf"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:27:43"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:27:43"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(245) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00061802-a-randomized-double-blind-study-to-evaluate-the-efficacy-and-safety-of-two-atypical-antipsychotics-vs-placebo-in-patients-with-an-acute-exacerbation-of-either-schizophrenia-or-schizoaf/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [93]=>
    object(WP_Post)#4868 (24) {
      ["ID"]=>
      int(1804)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-07-26 14:24:00"
      ["post_date_gmt"]=>
      string(19) "2019-07-26 14:24:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(237) "NCT01624675 - A Double-blind, Placebo-controlled Study, Followed by an Open-label Extension Study Evaluating the Efficacy and Safety of Risperidone (R064766) in Children and Adolescents With Irritability Associated With Autistic Disorder"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(194) "nct01624675-a-double-blind-placebo-controlled-study-followed-by-an-open-label-extension-study-evaluating-the-efficacy-and-safety-of-risperidone-r064766-in-children-and-adolescents-with-irritabil"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:27:46"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:27:46"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(243) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01624675-a-double-blind-placebo-controlled-study-followed-by-an-open-label-extension-study-evaluating-the-efficacy-and-safety-of-risperidone-r064766-in-children-and-adolescents-with-irritabil/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [94]=>
    object(WP_Post)#4867 (24) {
      ["ID"]=>
      int(1822)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-10-25 10:39:00"
      ["post_date_gmt"]=>
      string(19) "2019-10-25 10:39:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(142) "NCT00034775 - Open-Label Trial Exploring A Switching Regimen From Oral Neuroleptics, Other Than Risperidone, To Risperidone Depot Microspheres"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(138) "nct00034775-open-label-trial-exploring-a-switching-regimen-from-oral-neuroleptics-other-than-risperidone-to-risperidone-depot-microspheres"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:28:02"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:28:02"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(187) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00034775-open-label-trial-exploring-a-switching-regimen-from-oral-neuroleptics-other-than-risperidone-to-risperidone-depot-microspheres/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [95]=>
    object(WP_Post)#4866 (24) {
      ["ID"]=>
      int(1839)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-12-12 11:29:00"
      ["post_date_gmt"]=>
      string(19) "2019-12-12 11:29:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(159) "NCT00460512 - An Open-label Prospective Trial to Explore the Tolerability, Safety and Efficacy of Flexibly Dosed Paliperidone ER in Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(156) "nct00460512-an-open-label-prospective-trial-to-explore-the-tolerability-safety-and-efficacy-of-flexibly-dosed-paliperidone-er-in-subjects-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-04-09 12:25:00"
      ["post_modified_gmt"]=>
      string(19) "2024-04-09 16:25:00"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(205) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00460512-an-open-label-prospective-trial-to-explore-the-tolerability-safety-and-efficacy-of-flexibly-dosed-paliperidone-er-in-subjects-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [96]=>
    object(WP_Post)#4865 (24) {
      ["ID"]=>
      int(1841)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-12-12 11:40:00"
      ["post_date_gmt"]=>
      string(19) "2019-12-12 11:40:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(145) "NCT00566631 - Tolerability, Safety and Treatment Response of Flexible Doses of Paliperidone ER in Acutely Exacerbated Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(142) "nct00566631-tolerability-safety-and-treatment-response-of-flexible-doses-of-paliperidone-er-in-acutely-exacerbated-subjects-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:28:19"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:28:19"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(191) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00566631-tolerability-safety-and-treatment-response-of-flexible-doses-of-paliperidone-er-in-acutely-exacerbated-subjects-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [97]=>
    object(WP_Post)#4864 (24) {
      ["ID"]=>
      int(1843)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-12-12 11:47:00"
      ["post_date_gmt"]=>
      string(19) "2019-12-12 11:47:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(184) "NCT01515423 - A Randomized, Multicenter, Double-Blind, Non-inferiority Study of Paliperidone Palmitate 3 Month and 1 Month Formulations for the Treatment of Subjects With Schizophrenia"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(179) "nct01515423-a-randomized-multicenter-double-blind-non-inferiority-study-of-paliperidone-palmitate-3-month-and-1-month-formulations-for-the-treatment-of-subjects-with-schizophrenia"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2024-04-01 09:52:00"
      ["post_modified_gmt"]=>
      string(19) "2024-04-01 13:52:00"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(228) "https://dev-yoda.pantheonsite.io/clinical-trial/nct01515423-a-randomized-multicenter-double-blind-non-inferiority-study-of-paliperidone-palmitate-3-month-and-1-month-formulations-for-the-treatment-of-subjects-with-schizophrenia/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [98]=>
    object(WP_Post)#4863 (24) {
      ["ID"]=>
      int(1844)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2019-12-12 11:58:00"
      ["post_date_gmt"]=>
      string(19) "2019-12-12 11:58:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(251) "NCT02713282 - A 52-Week, Open-Label, Prospective, Multicenter, International Study of a Transition to the Paliperidone Palmitate 3-Month Formulation In Patients With Schizophrenia Previously Stabilized on the Paliperidone Palmitate 1-Month Formulation"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(194) "nct02713282-a-52-week-open-label-prospective-multicenter-international-study-of-a-transition-to-the-paliperidone-palmitate-3-month-formulation-in-patients-with-schizophrenia-previously-stabilize"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:28:21"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:28:21"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(243) "https://dev-yoda.pantheonsite.io/clinical-trial/nct02713282-a-52-week-open-label-prospective-multicenter-international-study-of-a-transition-to-the-paliperidone-palmitate-3-month-formulation-in-patients-with-schizophrenia-previously-stabilize/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
    [99]=>
    object(WP_Post)#4862 (24) {
      ["ID"]=>
      int(1915)
      ["post_author"]=>
      string(4) "1363"
      ["post_date"]=>
      string(19) "2021-04-02 12:24:00"
      ["post_date_gmt"]=>
      string(19) "2021-04-02 12:24:00"
      ["post_content"]=>
      string(0) ""
      ["post_title"]=>
      string(154) "NCT00095134 - A Double-Blind Study Comparing Adjunctive Risperidone Versus Placebo in Major Depressive Disorder That Is not Responding to Standard Therapy"
      ["post_excerpt"]=>
      string(0) ""
      ["post_status"]=>
      string(7) "publish"
      ["comment_status"]=>
      string(4) "open"
      ["ping_status"]=>
      string(4) "open"
      ["post_password"]=>
      string(0) ""
      ["post_name"]=>
      string(152) "nct00095134-a-double-blind-study-comparing-adjunctive-risperidone-versus-placebo-in-major-depressive-disorder-that-is-not-responding-to-standard-therapy"
      ["to_ping"]=>
      string(0) ""
      ["pinged"]=>
      string(0) ""
      ["post_modified"]=>
      string(19) "2023-02-06 13:29:36"
      ["post_modified_gmt"]=>
      string(19) "2023-02-06 13:29:36"
      ["post_content_filtered"]=>
      string(0) ""
      ["post_parent"]=>
      int(0)
      ["guid"]=>
      string(201) "https://dev-yoda.pantheonsite.io/clinical-trial/nct00095134-a-double-blind-study-comparing-adjunctive-risperidone-versus-placebo-in-major-depressive-disorder-that-is-not-responding-to-standard-therapy/"
      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(14) "clinical_trial"
      ["post_mime_type"]=>
      string(0) ""
      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
      string(3) "raw"
    }
  }
  ["project_date_type"]=>
  string(18) "full_crs_supp_docs"
  ["property_scientific_abstract"]=>
  string(1532) "Background: Antipsychotics are the mainstem for treating schizophrenia and other mental disorders. While use of antipsychotic treatment is essential for favorable outcomes in terms of acute efficacy and relapse prevention, the use of antipsychotics can cause various unpleasant side effects such as sedation, extrapyramidal symptoms, hyperprolactinemia, metabolic and cardiovascular disturbances, and anticholinergic side effects (1). These side effects are associated with a lower quality of life and poorer adherence in patients (2). It is known that patients acquire tolerance to some side effects in clinical practice whereas other side effects may get more severe over time. However, it is unclear when side effects occur and disappear.
Objective: We aim to systematically assess the occurrence, onset, duration and severity of side effects associated with antipsychotic treatment.
Study Design: This study is an Individual-Patient-Data (IPD) meta-analysis of clinical trials to evaluate the occurrence, onset, duration and severity of side effects associated with antipsychotic treatment.
Participants: Participants in clinical trials of antipsychotic drug monotherapy irrespective of diagnosis, age, gender, and ethnicity.
Main Outcome Measures: The occurrence, onset, duration, and severity of side effects associated with antipsychotic treatment
Statistical Analysis: The median time to onset and the duration of side effects will be calculated from synthesized data by IPD meta analysis." ["project_brief_bg"]=> string(1321) "Antipsychotics are the mainstem for the treatment of schizophrenia and used for the treatment of other psychiatric diseases. While the use of antipsychotic therapy is essential for favorable outcomes in terms of acute efficacy and relapse prevention, the use of antipsychotics can cause various unpleasant side effects such as sedation, extrapyramidal symptoms, hyperprolactinemia, metabolic and cardiovascular disturbances, and anticholinergic side effects (1). The impacts of side effects vary widely, ranging from very unpleasant in daily life (e.g., sedation, akathisia, weight gain, and constipation) to life-threatening (e.g., neuroleptic malignant syndrome, pneumonia, thromboembolism, and sudden cardiac death). Given these side effects are associated with a lower quality of life and poorer adherence in patients (2), proper management of side effects is important for a long-term treatment. However, the timeline of side effects has not been systematically studied. Knowing for example when side effects occur and disappear not only allows clinicians to optimize treatment with antipsychotics, but also helps patients monitor and manage their side effects. Therefore, this study aims to systematically assess the occurrence, onset, duration, and severity of side effects associated with antipsychotic treatment." ["project_specific_aims"]=> string(590) "The purpose of this project is to systematically assess temporal trajectories (the occurrence, onset, duration, and severity) of side effects associated with antipsychotic treatment and factors that could influence them.
Primary objective:
Evaluate temporal trajectories of antipsychotic-associated side-effects, e.g., time of onset, duration, temporal changes in severity, and time of disappearance.
Secondly objectives:
Evaluate factors (e.g., type of antipsychotic, dosage) that could influence temporal trajectories of antipsychotic-associated side-effects." ["project_study_design"]=> string(0) "" ["project_study_design_exp"]=> string(0) "" ["project_purposes"]=> array(0) { } ["project_purposes_exp"]=> string(0) "" ["project_software_used"]=> string(0) "" ["project_software_used_exp"]=> string(0) "" ["project_research_methods"]=> string(632) "We will consider prospective trials investigating the antipsychotic treatment in monotherapy without further restrictions, such as in terms of randomization, blinding, or follow-up duration. Any antipsychotic drug (ATC codes of N05., except lithium N05AN01) or placebo will be eligible. All participants in eligible studies will be included, irrespective of underlying diagnosis (e.g., schizophrenia, schizoaffective disorder, bipolar disorder, and children with disruptive behavior disorder), stage and severity of illness (e.g., acute, chronic), age (e.g., children, adolescent, and adults), gender, ethnicity, and comorbidities." ["project_main_outcome_measure"]=> string(860) "We will investigate temporal trajectories of antipsychotic-associated side-effects (e.g., time of onset, duration, changes in their severity, and time of disappearance).
We will consider 1) adverse events, such as extrapyramidal symptoms, akathisia, sedation, weight gain, prolactin elevation, QTc prolongation, and anticholinergic side-effects (e.g., constipation, blurred vision) We will use the Medical Dictionary for Regulatory Activities Terminology (MedDRA)(3) for the classification of adverse events. We will also consider 2) rating scale measures (e.g., Drug Induced Extra Pyramidal Symptoms Scale, Simpson-Angus Extrapyramidal Rating Scale, UKU side effect rating scale, Visual Analog Scale, Barnes Akathisia Rating Scale), and 3) biological measures (e.g., body weight, corrected QT interval on ECG, blood pressure, prolactin, blood glucose)" ["project_main_predictor_indep"]=> string(236) "The use of antipsychotics will be the independent variable.
The independent variable allows us to investigate the relationship between antipsychotic use and the onset, duration, and severity of the side effects of antipsychotics." ["project_other_variables_interest"]=> string(514) "We will consider factors with a potential influence on the temporal trajectories of antipsychotic-associated side-effects, such as specific antipsychotics, dosage of antipsychotics, administration route of antipsychotics, age, gender, ethnicity, diagnosis, life-time antipsychotic exposure (when not available, duration of illness will be used as a proxy in participants with schizophrenia), comorbid disorders, family history, smoking, baseline BMI, measures of psychopathology, and concomitant medications, etc." ["project_stat_analysis_plan"]=> string(2353) "First, we will conduct descriptive analysis on time to onset and duration of side effects, and then with statistical models that take temporal trajectories into account, such as the Kaplan-Meier method for binary adverse event data and Mixed-Models-of-Repeated-Measurements (MMRM) for rating-scale outcomes and biological measures. The effect size measures will be the time to onset and the time to resolution for binary adverse events and the change from baseline for rating-scale-outcomes or biological measures.
We consider occurrence and duration of somatic side effects of antipsychotics rather independent of the underlying psychiatric disease (e.g., schizophrenia or bipolar disorder) and therefore, we include a priori studies in different disorders. However, we expect variability in the effects due to differences in participant, intervention, and study characteristics. Therefore, we will explore sources of heterogeneity by subgroup and meta-regression analyses on potentially important effect modifiers such as age, sex, diagnosis (to investigate our assumption above), previous antipsychotic exposure, type, application and dose of antipsychotic, trial duration, RCT (Randomized control trial) and not RCT, ? (see list of ?Other Variables of Interest? above).
Variables which emerge as having a substantial effect on occurrence and duration of side effects will be included in the statistical model by introducing interactions.
We will handle missing outcome and covariate data following Little et al.(4) and impute it, when scientifically sound, by multiple imputations.
Effect size measures and covariates of different studies will be synthesized with meta-analysis.
I-squared and Tau-squared will be used to measure heterogeneity.
To estimate publication bias, we will use funnel plot and Egger?s test. In addition to examining the risk of small-trial/publication bias with funnel plots, we will investigate the potential risk of bias due to selection of reported results within the risk of bias assessment and the potential risk of bias due to selective non-reporting of results with the ROB-MEN(5) tool within the CINeMA assessment.
The standardized Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach will be used to examine the strength of evidence." ["project_timeline"]=> string(330) "Start of project: The study will start immediately after the data is available.
The actual state of the project: it is planned to finish data extraction and to start data analysis by 11/2022. The manuscript will be made and submitted in six months (6/2023). The publication is planned for the following six months(12/2023)." ["project_dissemination_plan"]=> string(489) "The results of this work will be a significant advancement in optimizing antipsychotic treatment for psychiatric disease, which in turn will reduce the burden for patients with schizophrenia and their caregivers, as well as medical costs in the long term. We will make the results available in several publications in scientific journals (e.g., JAMA Psychiatry, Lancet Psychiatry). Moreover, it is expected that the results will be included in local and international treatment guidelines." ["project_bibliography"]=> string(1188) "

1. Huhn M, Nikolakopoulou A, Schneider-Thoma J, Krause M, Samara M, Peter N, et al. Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis. Lancet. 2019; 394(10202): 939-51.
2. Dibonaventura M, Gabriel S, Dupclay L, Gupta S, Kim E. A patient perspective of the impact of medication side effects on adherence: results of a cross-sectional nationwide survey of patients with schizophrenia. BMC Psychiatry. 2012; 12(1): 20.
3. International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH). Medical Dictionary for Regulatory Activities Terminology (MedDRA). www.meddra.org.
4. Little RJ, D’Agostino R, Cohen ML, Dickersin K, Emerson SS, Farrar JT, et al. The Prevention and Treatment of Missing Data in Clinical Trials. New England Journal of Medicine. 2012; 367(14): 1355-60.
5. Chiocchia V, Nikolakopoulou A, Higgins JPT, Page MJ, Papakonstantinou T, Cipriani A, et al. ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis. BMC Medicine. 2021; 19(1).

" ["project_suppl_material"]=> bool(false) ["project_coi"]=> array(5) { [0]=> array(1) { ["file_coi"]=> array(21) { ["ID"]=> int(9470) ["id"]=> int(9470) ["title"]=> string(13) "stefan_leucht" ["filename"]=> string(17) "stefan_leucht.pdf" ["filesize"]=> int(32797) ["url"]=> string(66) "https://yoda.yale.edu/wp-content/uploads/2019/04/stefan_leucht.pdf" ["link"]=> string(59) "https://yoda.yale.edu/data-request/2022-4992/stefan_leucht/" ["alt"]=> string(0) "" ["author"]=> string(4) "1363" ["description"]=> string(0) "" ["caption"]=> string(0) "" ["name"]=> string(13) "stefan_leucht" ["status"]=> string(7) "inherit" ["uploaded_to"]=> int(6063) ["date"]=> string(19) "2023-07-31 15:44:03" ["modified"]=> string(19) "2023-08-01 00:57:31" ["menu_order"]=> int(0) ["mime_type"]=> string(15) "application/pdf" ["type"]=> string(11) "application" ["subtype"]=> string(3) "pdf" ["icon"]=> string(62) "https://yoda.yale.edu/wp/wp-includes/images/media/document.png" } } [1]=> array(1) { ["file_coi"]=> array(21) { ["ID"]=> int(9360) ["id"]=> int(9360) ["title"]=> string(15) "nobuyuki_nomura" ["filename"]=> string(19) "nobuyuki_nomura.pdf" ["filesize"]=> int(29253) ["url"]=> string(68) "https://yoda.yale.edu/wp-content/uploads/2018/04/nobuyuki_nomura.pdf" ["link"]=> string(61) "https://yoda.yale.edu/data-request/2022-4992/nobuyuki_nomura/" ["alt"]=> string(0) "" ["author"]=> string(4) "1363" ["description"]=> string(0) "" ["caption"]=> string(0) "" ["name"]=> string(15) "nobuyuki_nomura" ["status"]=> string(7) "inherit" ["uploaded_to"]=> int(6063) ["date"]=> string(19) "2023-07-31 15:38:35" ["modified"]=> string(19) "2023-08-01 00:57:31" ["menu_order"]=> int(0) ["mime_type"]=> string(15) "application/pdf" ["type"]=> string(11) "application" ["subtype"]=> string(3) "pdf" ["icon"]=> string(62) "https://yoda.yale.edu/wp/wp-includes/images/media/document.png" } } [2]=> array(1) { ["file_coi"]=> array(21) { ["ID"]=> int(9287) ["id"]=> int(9287) ["title"]=> string(24) "johannes_schneider-thoma" ["filename"]=> string(28) "johannes_schneider-thoma.pdf" ["filesize"]=> int(19813) ["url"]=> string(77) "https://yoda.yale.edu/wp-content/uploads/2020/02/johannes_schneider-thoma.pdf" ["link"]=> string(70) "https://yoda.yale.edu/data-request/2022-4992/johannes_schneider-thoma/" ["alt"]=> string(0) "" ["author"]=> string(4) "1363" ["description"]=> string(0) "" ["caption"]=> string(0) "" ["name"]=> string(24) "johannes_schneider-thoma" ["status"]=> string(7) "inherit" ["uploaded_to"]=> int(6063) ["date"]=> string(19) "2023-07-31 15:35:20" ["modified"]=> string(19) "2023-08-01 00:57:31" ["menu_order"]=> int(0) ["mime_type"]=> string(15) "application/pdf" ["type"]=> string(11) "application" ["subtype"]=> string(3) "pdf" ["icon"]=> string(62) "https://yoda.yale.edu/wp/wp-includes/images/media/document.png" } } [3]=> array(1) { ["file_coi"]=> array(21) { ["ID"]=> int(9453) ["id"]=> int(9453) ["title"]=> string(11) "siafis_cois" ["filename"]=> string(15) "siafis_cois.pdf" ["filesize"]=> int(19429) ["url"]=> string(64) "https://yoda.yale.edu/wp-content/uploads/2020/08/siafis_cois.pdf" ["link"]=> string(57) "https://yoda.yale.edu/data-request/2022-4992/siafis_cois/" ["alt"]=> string(0) "" ["author"]=> string(4) "1363" ["description"]=> string(0) "" ["caption"]=> string(0) "" ["name"]=> string(11) "siafis_cois" ["status"]=> string(7) "inherit" ["uploaded_to"]=> int(6063) ["date"]=> string(19) "2023-07-31 15:43:14" ["modified"]=> string(19) "2023-08-01 00:57:31" ["menu_order"]=> int(0) ["mime_type"]=> string(15) "application/pdf" ["type"]=> string(11) "application" ["subtype"]=> string(3) "pdf" ["icon"]=> string(62) "https://yoda.yale.edu/wp/wp-includes/images/media/document.png" } } [4]=> array(1) { ["file_coi"]=> array(21) { ["ID"]=> int(9259) ["id"]=> int(9259) ["title"]=> string(18) "hiroyoshi_takeuchi" ["filename"]=> string(22) "hiroyoshi_takeuchi.pdf" ["filesize"]=> int(33227) ["url"]=> string(71) "https://yoda.yale.edu/wp-content/uploads/2016/10/hiroyoshi_takeuchi.pdf" ["link"]=> string(64) "https://yoda.yale.edu/data-request/2022-4992/hiroyoshi_takeuchi/" ["alt"]=> string(0) "" ["author"]=> string(4) "1363" ["description"]=> string(0) "" ["caption"]=> string(0) "" ["name"]=> string(18) "hiroyoshi_takeuchi" ["status"]=> string(7) "inherit" ["uploaded_to"]=> int(6063) ["date"]=> string(19) "2023-07-31 15:34:06" ["modified"]=> string(19) "2023-08-01 00:57:31" ["menu_order"]=> int(0) ["mime_type"]=> string(15) "application/pdf" ["type"]=> string(11) "application" ["subtype"]=> string(3) "pdf" ["icon"]=> string(62) "https://yoda.yale.edu/wp/wp-includes/images/media/document.png" } } } ["data_use_agreement_training"]=> bool(true) ["certification"]=> bool(true) ["project_send_email_updates"]=> bool(true) ["project_status"]=> string(7) "ongoing" ["project_publ_available"]=> bool(true) ["project_year_access"]=> string(4) "2022" ["project_rep_publ"]=> array(1) { [0]=> array(1) { ["publication_link"]=> string(0) "" } } ["project_assoc_data"]=> array(0) { } ["project_due_dil_assessment"]=> array(21) { ["ID"]=> int(10568) ["id"]=> int(10568) ["title"]=> string(47) "yoda_project_due_diligence_assessment_2022-4992" ["filename"]=> string(51) "yoda_project_due_diligence_assessment_2022-4992.pdf" ["filesize"]=> int(133702) ["url"]=> string(100) "https://yoda.yale.edu/wp-content/uploads/2023/08/yoda_project_due_diligence_assessment_2022-4992.pdf" ["link"]=> string(93) "https://yoda.yale.edu/data-request/2022-4992/yoda_project_due_diligence_assessment_2022-4992/" ["alt"]=> string(0) "" ["author"]=> string(4) "1363" ["description"]=> string(0) "" ["caption"]=> string(0) "" ["name"]=> string(47) "yoda_project_due_diligence_assessment_2022-4992" ["status"]=> string(7) "inherit" ["uploaded_to"]=> int(6063) ["date"]=> string(19) "2023-08-09 17:02:14" ["modified"]=> string(19) "2023-08-09 19:12:24" ["menu_order"]=> int(0) ["mime_type"]=> string(15) "application/pdf" ["type"]=> string(11) "application" ["subtype"]=> string(3) "pdf" ["icon"]=> string(62) "https://yoda.yale.edu/wp/wp-includes/images/media/document.png" } ["project_title_link"]=> array(21) { ["ID"]=> int(10566) ["id"]=> int(10566) ["title"]=> string(42) "yoda_project_protocol-2022-4992-2022-07-11" ["filename"]=> string(46) "yoda_project_protocol-2022-4992-2022-07-11.pdf" ["filesize"]=> int(45281) ["url"]=> string(95) "https://yoda.yale.edu/wp-content/uploads/2023/08/yoda_project_protocol-2022-4992-2022-07-11.pdf" ["link"]=> string(88) "https://yoda.yale.edu/data-request/2022-4992/yoda_project_protocol-2022-4992-2022-07-11/" ["alt"]=> string(0) "" ["author"]=> string(4) "1363" ["description"]=> string(0) "" ["caption"]=> string(0) "" ["name"]=> string(42) "yoda_project_protocol-2022-4992-2022-07-11" ["status"]=> string(7) "inherit" ["uploaded_to"]=> int(6063) ["date"]=> string(19) "2023-08-09 17:02:08" ["modified"]=> string(19) "2023-08-09 19:12:25" ["menu_order"]=> int(0) ["mime_type"]=> string(15) "application/pdf" ["type"]=> string(11) "application" ["subtype"]=> string(3) "pdf" ["icon"]=> string(62) "https://yoda.yale.edu/wp/wp-includes/images/media/document.png" } ["project_review_link"]=> array(21) { ["ID"]=> int(10565) ["id"]=> int(10565) ["title"]=> string(39) "yoda_project_review_-_2022-4992_sitepdf" ["filename"]=> string(43) "yoda_project_review_-_2022-4992_sitepdf.pdf" ["filesize"]=> int(1746901) ["url"]=> string(92) "https://yoda.yale.edu/wp-content/uploads/2023/08/yoda_project_review_-_2022-4992_sitepdf.pdf" ["link"]=> string(85) "https://yoda.yale.edu/data-request/2022-4992/yoda_project_review_-_2022-4992_sitepdf/" ["alt"]=> string(0) "" ["author"]=> string(4) "1363" ["description"]=> string(0) "" ["caption"]=> string(0) "" ["name"]=> string(39) "yoda_project_review_-_2022-4992_sitepdf" ["status"]=> string(7) "inherit" ["uploaded_to"]=> int(6063) ["date"]=> string(19) "2023-08-09 17:02:06" ["modified"]=> string(19) "2023-08-09 19:12:25" ["menu_order"]=> int(0) ["mime_type"]=> string(15) "application/pdf" ["type"]=> string(11) "application" ["subtype"]=> string(3) "pdf" ["icon"]=> string(62) "https://yoda.yale.edu/wp/wp-includes/images/media/document.png" } ["project_highlight_button"]=> string(0) "" ["request_data_partner"]=> string(15) "johnson-johnson" ["search_order"]=> string(5) "-8220" ["principal_investigator"]=> array(7) { ["first_name"]=> string(6) "Stefan" ["last_name"]=> string(6) "Leucht" ["degree"]=> string(2) "MD" ["primary_affiliation"]=> string(30) "Technical University of Munich" ["email"]=> string(20) "stefan.leucht@tum.de" ["state_or_province"]=> string(7) "Bavaria" ["country"]=> string(7) "Germany" } ["request_overridden_res"]=> string(1) "3" } data partner
array(1) { [0]=> string(15) "johnson-johnson" }

pi country
array(1) { [0]=> string(7) "Germany" }

pi affil
array(1) { [0]=> string(5) "Other" }

products
array(4) { [0]=> string(6) "invega" [1]=> string(15) "invega-sustenna" [2]=> string(16) "risperdal-consta" [3]=> string(9) "risperdal" }

num of trials
array(1) { [0]=> string(3) "100" }

res
array(1) { [0]=> string(1) "3" }

2022-4992

General Information

How did you learn about the YODA Project?: Colleague

Conflict of Interest

Request Clinical Trials

Associated Trial(s):
  1. NCT00488319 - A 2-Year, Open-Label, Single-Arm Safety Study of Flexibly Dosed Paliperidone Extended Release (1.5-12 mg/day) in the Treatment of Adolescents (12 to 17 Years of Age) With Schizophrenia
  2. NCT01009047 - A Randomized, Multicenter, Double-Blind, Active-Controlled, Flexible-Dose, Parallel-Group Study of the Efficacy and Safety of Prolonged Release Paliperidone for the Treatment of Symptoms of Schizophrenia in Adolescent Subjects, 12 to 17 Years of Age
  3. NCT00645099 - A Prospective Randomized Open-label 6-Month Head-To-Head Trial to Compare Metabolic Effects of Paliperidone ER and Olanzapine in Subjects With Schizophrenia
  4. NCT00518323 - A Randomized, Multicenter, Double-Blind, Weight-Based, Fixed-Dose, Parallel-Group, Placebo-Controlled Study of the Efficacy and Safety of Extended Release Paliperidone for the Treatment of Schizophrenia in Adolescent Subjects, 12 to 17 Years of Age
  5. NCT01606228 - An Open-Label Prospective Trial to Explore the Tolerability, Safety and Efficacy of Flexibly-Dosed Paliperidone ER among Treatment-Naive and Newly Diagnosed Patients with Schizophrenia
  6. NCT00334126 - A Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Paliperidone ER Compared to Quetiapine in Subjects With an Acute Exacerbation of Schizophrenia
  7. NCT00086320 - A Randomized, Double-blind, Placebo-controlled, Parallel-group Study With an Open-label Extension Evaluating Paliperidone Extended Release Tablets in the Prevention of Recurrence in Subjects With Schizophrenia
  8. NCT00589914 - A Randomized, Double-Blind, Parallel-Group, Comparative Study of Flexible Doses of Paliperidone Palmitate and Flexible Doses of Risperidone Long-Acting Intramuscular Injection in Subjects With Schizophrenia
  9. NCT00604279 - A Randomized, Open-Label, Parallel Group Comparative Study of Paliperidone Palmitate (50, 100, 150 mg eq) and Risperidone LAI (25, 37.5, or 50 mg) in Subjects with Schizophrenia
  10. NCT00590577 - A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose Response Study to Evaluate the Efficacy and Safety of 3 Fixed Doses (25 mg eq., 100 mg eq., and 150 mg eq.) of Paliperidone Palmitate in Subjects With Schizophrenia
  11. NCT00111189 - A Randomized Double-blind Placebo-controlled Parallel Group Study Evaluating Paliperidone Palmitate in the Prevention of Recurrence in Patients With Schizophrenia. Placebo Consists of 20% Intralipid (200 mg/mL) Injectable Emulsion
  12. NCT00210717 - A Randomized, Double-Blind, Parallel Group, Comparative Study of Flexibly Dosed Paliperidone Palmitate (25, 50, 75, or 100 mg eq.) Administered Every 4 Weeks and Flexibly Dosed RISPERDAL CONSTA (25, 37.5, or 50 mg) Administered Every 2 Weeks in Subjects With Schizophrenia
  13. NCT00119756 - A Randomized, Crossover Study to Evaluate the Overall Safety and Tolerability of Paliperidone Palmitate Injected in the Deltoid or Gluteus Muscle in Patients With Schizophrenia
  14. NCT00210548 - A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Response Study to Evaluate the Efficacy and Safety of 3 Fixed Doses (50 mg eq., 100 mg eq., and 150 mg eq.) of Paliperidone Palmitate in Subjects With Schizophrenia
  15. NCT00101634 - A Randomized, Double-blind, Placebo-controlled, Parallel-group, Dose-response Study to Evaluate the Efficacy and Safety of 3 Fixed Doses (25 mg eq, 50 mg eq, and 100 mg eq) of Paliperidone Palmitate in Patients With Schizophrenia
  16. NCT00391222 - A Randomized, Double Blind, Placebo and Active Controlled Parallel Group Study to Evaluate the Efficacy and Safety of Risperidone Long-acting Injectable (LAI) for the Prevention of Mood Episodes in the Treatment of Subjects With Bipolar I Disorder
  17. NCT00034749 - The Efficacy and Safety of Risperidone in Adolescents With Schizophrenia: a Comparison of Two Dose Ranges of Risperidone
  18. NCT00076115 - Research on the Effectiveness of Risperidone in Bipolar Disorder in Adolescents and Children (REACH): A Double-Blind, Randomized, Placebo-Controlled Study of the Efficacy and Safety of Risperidone for the Treatment of Acute Mania in Bipolar I Disorder
  19. NCT00132678 - A Randomized, Double-blind, Placebo-controlled Study to Explore the Efficacy and Safety of Risperidone Long-acting Intramuscular Injectable in the Prevention of Mood Episodes in Bipolar 1 Disorder, With Open-label Extension
  20. NCT00094926 - A Prospective, Randomized, Double-blind, Placebo-controlled Study of the Effectiveness and Safety of RISPERDAL CONSTA Augmentation in Adult Patients With Frequently-relapsing Bipolar Disorder
  21. NCT00397033 - A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy and Safety of Two Dosages of Paliperidone ER in the Treatment of Patients With Schizoaffective Disorder
  22. NCT00412373 - A Randomized, Double-blind, Placebo-controlled, Parallel- Group Study to Evaluate the Efficacy and Safety of Flexible-dose Paliperidone ER in the Treatment of Patients With Schizoaffective Disorder
  23. NCT00236444 - Risperidone in the Prevention of Relapse: a Randomized, Double-blind, Placebo-controlled Trial in Children and Adolescents With Conduct and Other Disruptive Behavior Disorders
  24. NCT00236470 - Risperidone in the Treatment of Children and Adolescents With Conduct and Other Disruptive Behavior Disorders - an Open Label Follow-up Trial of CR002020
  25. NCT00250354 - The Safety And Efficacy Of Risperidone Versus Placebo In Conduct Disorder In Mild, Moderate And Borderline Mentally Retarded Children Aged 5 To 12 Years
  26. NCT00266552 - The Safety And Efficacy Of Risperidone Versus Placebo In Conduct Disorder and Other Disruptive Behavior Disorders In Mild, Moderate And Borderline Mentally Retarded Children Aged 5 To 12 Years
  27. NCT00249132 - A Canadian multicenter placebo-controlled study of fixed doses of risperidone and haloperidol in the treatment of chronic schizophrenic patients
  28. NCT00216476 - CONSTATRE: Risperdal® Consta® Trial of Relapse Prevention and Effectiveness
  29. NCT00216580 - An Open-label Trial of Risperidone Long-acting Injectable in the Treatment of Subjects With Recent Onset Psychosis
  30. NCT00253162 - The Efficacy And Safety Of Flexible Dose Ranges Of Risperidone Versus Placebo Or Haloperidol In The Treatment Of Manic Episodes Associated With Bipolar I Disorder
  31. NCT00378092 - A Prospective Study of the Clinical Outcome Following Treatment Discontinuation After Remission in First-Episode Schizophrenia
  32. NCT00299715 - A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Response, Multicenter Study to Evaluate the Efficacy and Safety of Three Fixed Doses of Extended-Release Paliperidone in the Treatment of Subjects With Acute Manic and Mixed Episodes Associated With Bipolar I Disorder
  33. NCT00309699 - A Randomized, Double-Blind, Active- and Placebo-Controlled, Parallel-Group, Multicenter Study to Evaluate the Efficacy and Safety of Flexibly-Dosed, Extended-Release Paliperidone Compared With Flexibly-Dosed Quetiapine and Placebo in the Treatment of Acute Manic and Mixed Episodes Associated With Bipolar I Disorder
  34. NCT00309686 - A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study to Evaluate the Efficacy and Safety of Flexibly-Dosed Extended-Release Paliperidone as Adjunctive Therapy to Mood Stabilizers in the Treatment of Acute Manic and Mixed Episodes Associated With Bipolar I Disorder
  35. NCT00752427 - 24 week extension of NCT00085748: A Randomized, 6-Week Double-Blind, Placebo-Controlled Study With an Optional 24-Week Open-Label Extension to Evaluate the Safety and Tolerability of Flexible Doses of Paliperidone Extended Release in the Treatment of Geriatric Patients With Schizophrenia
  36. NCT00077714 - A Randomized, Double-blind, Placebo- and Active-controlled, Parallel-group, Dose-response Study to Evaluate the Efficacy and Safety of 2 Fixed Dosages of Paliperidone Extended Release Tablets and Olanzapine, With Open-label Extension, in the Treatment of Patients With Schizophrenia
  37. NCT00083668 - A Randomized, Double-blind, Placebo- and Active-controlled, Parallel-group, Dose-response Study to Evaluate the Efficacy and Safety of 3 Fixed Dosages of Paliperidone Extended Release (ER) Tablets and Olanzapine, With Open-label Extension, in the Treatment of Patients With Schizophrenia
  38. NCT00074477 - A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of 50 and 100 Mg-eq of Paliperidone Palmitate in Patients With Schizophrenia
  39. NCT00078039 - Trial Evaluating Three Fixed Dosages of Paliperidone Extended-Release (ER) Tablets and Olanzapine in the Treatment of Patients With Schizophrenia
  40. NCT00085748 - A Randomized, 6-Week Double-Blind, Placebo-Controlled Study With an Optional 24-Week Open-Label Extension to Evaluate the Safety and Tolerability of Flexible Doses of Paliperidone Extended Release in the Treatment of Geriatric Patients With Schizophrenia
  41. NCT00249158 - Risperidone in the Treatment of Behavioural and Psychological Signs and Symptoms in Dementia (BPSSD): a Multicentre, Double-blind, Placebo-controlled Parallel-group Trial
  42. Risperidone in the treatment of behavioural disturbances in patients with Alzheimer's dementia: a double-blind placebo-controlled trial
  43. NCT00261508 - Efficacy And Safety Of Risperidone In The Treatment Of Children With Autistic Disorder And Other Pervasive Developmental Disorders: A Canadian, Multicenter, Double-Blind, Placebo-Controlled Study
  44. NCT00249236 - The Efficacy And Safety Of Flexible Dosage Ranges Of Risperidone Versus Placebo In The Treatment Of Manic Or Mixed Episodes Associated With Bipolar I Disorder
  45. NCT00249145 - Risperidone in the Treatment of Behavioral Disturbances in Demented Patients: an International, Multicenter, Placebo-controlled, Double-blind, Parallel-group Trial Using Haloperidol as Internal Reference
  46. NCT00250367 - The Safety And Efficacy Of Risperdal (Risperidone) Versus Placebo As Add-On Therapy To Mood Stabilizers In The Treatment Of The Manic Phase Of Bipolar Disorder
  47. Efficacy and safety of a flexible dose of risperidone versus placebo in the treatment of psychosis of Alzheimer’s disease. A double-blind, placebo-controlled, parallel-group study.
  48. NCT00088075 - A Randomized, Double-Blind, Placebo-Controlled Clinical Study of the Efficacy and Safety of Risperidone for the Treatment of Schizophrenia in Adolescents
  49. Risperidone versus haloperidol versus placebo in the treatment of schizophrenia
  50. NCT00253149 - The Safety And Efficacy Of Risperdal (Risperidone) Versus Placebo Versus Haloperidol As Add-On Therapy To Mood Stabilizers In The Treatment Of The Manic Phase Of Bipolar Disorder
  51. NCT00253136 - Risperidone Depot (Microspheres) vs. Placebo in the Treatment of Subjects With Schizophrenia
  52. A double-blind, placebo-controlled study of risperidone in children and adolescents with autistic disorder
  53. NCT00034762 - Efficacy And Safety Of A Flexible Dose Of Risperidone Versus Placebo In The Treatment Of Psychosis Of Alzheimer's Disease
  54. NCT00257075 - The Efficacy And Safety Of Flexible Dosage Ranges Of Risperidone Versus Placebo In The Treatment Of Manic Episodes Associated With Bipolar I Disorder
  55. The efficacy and safety of flexible dose ranges of risperidone vs. Placebo or divalproex sodium in the treatment of manic or mixed episodes associated with bipolar 1 disorder
  56. NCT00253123 - A Randomized, Double-Blind, Placebo-Controlled Study of Risperidone for Treatment of Behavioral Disturbances in Subjects With Dementia
  57. The safety and efficacy of risperidone 8 mg qd and 4 mg qd compared to placebo in the treatment of schizophrenia
  58. NCT01529515 - A Randomized, Multicenter, Double-Blind, Relapse Prevention Study of Paliperidone Palmitate 3 Month Formulation for the Treatment of Subjects With Schizophrenia
  59. NCT01193153 - A Randomized, Double-Blind, Placebo-Controlled, Parellel-Group Study of Paliperidone Palmitate Evaluating Time to Relapse in Subjects With Schizoaffective Disorder
  60. NCT01662310 - Paliperidone Extended Release Tablets for the Prevention of Relapse in Subjects With Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study
  61. NCT00490971 - A Randomized, Double-Blind, Active- and Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Extended-Release Paliperidone as Maintenance Treatment After an Acute Manic or Mixed Episode Associated With Bipolar I Disorder
  62. NCT00524043 - A Randomized, Double-Blind, Placebo- and Active-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of a Fixed Dosage of 1.5 mg/Day of Paliperidone Extended Release (ER) in the Treatment of Subjects With Schizophrenia
  63. NCT00105326 - A Double-blind, Placebo-controlled, Randomized Study Evaluating the Effect of Paliperidone ER Compared With Placebo on Sleep Architecture in Subjects With Schizophrenia
  64. An open-label, long-term study of risperidone for the treatment of behavioral disturbances in patients with dementia
  65. NCT00246246 - A Randomized, Open-label Trial of RISPERDAL® CONSTA™ Versus Oral Antipsychotic Care in Subjects With Bipolar Disorder
  66. NCT00044681 - A Study to Evaluate the Efficacy, Safety and Maintenance Effect of Risperidone Augmentation of SSRI Monotherapy in Young and Older Adult Patients With Unipolar Treatment-Resistant Depression
  67. NCT00249223 - Risperidone Depot (Microspheres) vs. Risperidone Tablets - a Non-inferiority, Efficacy Trial in Subjects With Schizophrenia
  68. NCT01157351 - A Fifteen-month, Prospective, Randomized, Active-controlled, Open-label, Flexible Dose Study of Paliperidone Palmitate Compared With Oral Antipsychotic Treatment in Delaying Time to Treatment Failure in Adults With Schizophrenia Who Have Been Incarcerated
  69. NCT01081769 - A 24-month, Prospective, Randomized, Active-Controlled, Open-Label, Rater-Blinded, Multicenter, International Study of the Prevention of Relapse Comparing Long-Acting Injectable Paliperidone Palmitate to Treatment as Usual With Oral Antipsychotic Monotherapy in Adults With Schizophrenia
  70. NCT01281527 - A 6-month, Open Label, Prospective, Multicenter, International, Exploratory Study of a Transition to Flexibly Dosed Paliperidone Palmitate in Patients With Schizophrenia Previously Unsuccessfully Treated With Oral or Long-acting Injectable Antipsychotics
  71. NCT01051531 - Safety, Tolerability, and Treatment Response of Paliperidone Palmitate in Subjects With Schizophrenia When Switching From Oral Antipsychotics
  72. NCT01527305 - An Open-Label, Prospective, Non-Comparative Study to Evaluate the Efficacy and Safety of Paliperidone Palmitate in Subjects With Acute Schizophrenia
  73. NCT01299389 - A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Fixed-Dose, Multicenter Study of JNS010 (Paliperidone Palmitate) in Patients With Schizophrenia
  74. NCT01258920 - A Long-Term, Open-Label Study of Flexibly Dosed Paliperidone Palmitate Long-Acting Intramuscular Injection in Japanese Patients With Schizophrenia
  75. NCT00216671 - Early Versus Late Initiation of Treatment With Risperdal Consta in Subjects With Schizophrenia After an Acute Episode
  76. NCT00369239 - Is Premorbid Functioning a Predictor of Outcome in Patients With Early Onset Psychosis Treated With Risperdal Consta?
  77. NCT00216632 - Treatment Success in Patients Requiring Treatment Change From Olanzapine to Risperidone Long Acting Injectable (TRESOR)
  78. NCT00236379 - A Six-month, Double-blind, Randomized, International, Multicenter Trial to Evaluate the Glucoregulatory Effects of Risperidone and Olanzapine in Subjects With Schizophrenia or Schizoaffective Disorder
  79. NCT00576732 - Risperidone in the Treatment of Children and Adolescents With Autistic Disorder: A Double-Blind, Placebo-Controlled Study of Efficacy and Safety, Followed by an Open-Label Extension Study of Safety
  80. NCT01050582 - Evaluation of Growth, Sexual Maturation, and Prolactin-Related Adverse Events in the Pediatric Population Exposed to Atypical Antipsychotic Drugs
  81. NCT00086112 - A Double-blind, Randomized, Prospective Study to Evaluate Adjunctive Risperidone Versus Adjunctive Placebo in Generalized Anxiety Disorder Sub-optimally Responsive to Standard Psychotropic Therapy
  82. NCT00216528 - A Prospective, Open-Label Study to Evaluate Symptomatic Remission in Schizophrenia With Long Acting Risperidone Microspheres (Risperdal Consta)
  83. NCT00269919 - Effect on Efficacy, Safety and Quality of Life by Long-Term Treatment of Long-Acting Risperidone Microspheres in Patients With Schizophrenia
  84. NCT00992407 - A Randomized, Open-label, Active-controlled Study to Evaluate Social Functioning of Long Acting Injectable Risperidone and Oral Risperidone in the Treatment of Subjects With Schizophrenia or Schizoaffective Disorder
  85. NCT00236353 - An Open-label Study of the Efficacy and Safety of RISPERDAL Long-acting Microspheres (RISPERDAL CONSTA) Administered Once Monthly in Adults With Schizophrenia or Schizoaffective Disorder
  86. NCT00495118 - Risperidone Depot (Microspheres) in the Treatment of Subjects With Schizophrenia or Schizoaffective Disorder - an Open-label Follow-up Trial of RIS-INT-62 and RIS-INT-85
  87. NCT01855074 - Evaluation of Efficacy and Safety of Risperidone in Long-acting Microspheres in Patients With Schizophrenia, Schizophreniform or Schizoaffective Disorders Diagnosed According to the DSM-IV Criteria, After Switching Treatment With Any Antipsychotic Therapy With Long-acting Microspheres of Risperidone
  88. NCT00236457 - Randomized, Multi-center, Open Label Trial Comparing Risperidone Depot (Microspheres) and Olanzapine Tablets in Patients With Schizophrenia or Schizoaffective Disorder
  89. NCT00236587 - An Open Label, Long Term Trial of Risperidone Long Acting Microspheres in the Treatment of Patients Diagnosed With Schizophrenia
  90. NCT00297388 - A 52-wk Prospective, Randomized, Double-blind, Multicenter Study of Relapse Following Transition From Oral Antipsychotic Medication to 2 Different Doses (25 or 50 mg Every 2 Wks) of Risperidone Long-acting Microspheres (RISPERDAL CONSTA) in Adults With Schizophrenia or Schizoaffective Disorder
  91. NCT00821600 - Single-Dose, Open-Label Pilot Study to Explore the Pharmacokinetics, Safety and Tolerability of a Gluteal Intramuscular Injection of a 4-Week Long-Acting Injectable Formulation of Risperidone in Patients With Chronic Stable Schizophrenia
  92. NCT00526877 - Evaluation of Efficacy and Safety of Long-acting Risperidone Microspheres in Patients With Schizophrenia or Schizoaffective Disorders, Who is Receiving Psychiatric Home-care Treatment, When Switching From Typical Depot or Oral Antipsychotics to Long-acting Risperidone Microspheres
  93. NCT00061802 - A Randomized, Double Blind Study to Evaluate the Efficacy and Safety of Two Atypical Antipsychotics vs. Placebo in Patients With an Acute Exacerbation of Either Schizophrenia or Schizoaffective Disorder
  94. NCT01624675 - A Double-blind, Placebo-controlled Study, Followed by an Open-label Extension Study Evaluating the Efficacy and Safety of Risperidone (R064766) in Children and Adolescents With Irritability Associated With Autistic Disorder
  95. NCT00034775 - Open-Label Trial Exploring A Switching Regimen From Oral Neuroleptics, Other Than Risperidone, To Risperidone Depot Microspheres
  96. NCT00460512 - An Open-label Prospective Trial to Explore the Tolerability, Safety and Efficacy of Flexibly Dosed Paliperidone ER in Subjects With Schizophrenia
  97. NCT00566631 - Tolerability, Safety and Treatment Response of Flexible Doses of Paliperidone ER in Acutely Exacerbated Subjects With Schizophrenia
  98. NCT01515423 - A Randomized, Multicenter, Double-Blind, Non-inferiority Study of Paliperidone Palmitate 3 Month and 1 Month Formulations for the Treatment of Subjects With Schizophrenia
  99. NCT02713282 - A 52-Week, Open-Label, Prospective, Multicenter, International Study of a Transition to the Paliperidone Palmitate 3-Month Formulation In Patients With Schizophrenia Previously Stabilized on the Paliperidone Palmitate 1-Month Formulation
  100. NCT00095134 - A Double-Blind Study Comparing Adjunctive Risperidone Versus Placebo in Major Depressive Disorder That Is not Responding to Standard Therapy
What type of data are you looking for?: Individual Participant-Level Data, which includes Full CSR and all supporting documentation

Request Clinical Trials

Data Request Status

Status: Ongoing

Research Proposal

Project Title: Temporal trajectories of side-effects associated with antipsychotic treatment ? An individual participant data meta-analysis

Scientific Abstract: Background: Antipsychotics are the mainstem for treating schizophrenia and other mental disorders. While use of antipsychotic treatment is essential for favorable outcomes in terms of acute efficacy and relapse prevention, the use of antipsychotics can cause various unpleasant side effects such as sedation, extrapyramidal symptoms, hyperprolactinemia, metabolic and cardiovascular disturbances, and anticholinergic side effects (1). These side effects are associated with a lower quality of life and poorer adherence in patients (2). It is known that patients acquire tolerance to some side effects in clinical practice whereas other side effects may get more severe over time. However, it is unclear when side effects occur and disappear.
Objective: We aim to systematically assess the occurrence, onset, duration and severity of side effects associated with antipsychotic treatment.
Study Design: This study is an Individual-Patient-Data (IPD) meta-analysis of clinical trials to evaluate the occurrence, onset, duration and severity of side effects associated with antipsychotic treatment.
Participants: Participants in clinical trials of antipsychotic drug monotherapy irrespective of diagnosis, age, gender, and ethnicity.
Main Outcome Measures: The occurrence, onset, duration, and severity of side effects associated with antipsychotic treatment
Statistical Analysis: The median time to onset and the duration of side effects will be calculated from synthesized data by IPD meta analysis.

Brief Project Background and Statement of Project Significance: Antipsychotics are the mainstem for the treatment of schizophrenia and used for the treatment of other psychiatric diseases. While the use of antipsychotic therapy is essential for favorable outcomes in terms of acute efficacy and relapse prevention, the use of antipsychotics can cause various unpleasant side effects such as sedation, extrapyramidal symptoms, hyperprolactinemia, metabolic and cardiovascular disturbances, and anticholinergic side effects (1). The impacts of side effects vary widely, ranging from very unpleasant in daily life (e.g., sedation, akathisia, weight gain, and constipation) to life-threatening (e.g., neuroleptic malignant syndrome, pneumonia, thromboembolism, and sudden cardiac death). Given these side effects are associated with a lower quality of life and poorer adherence in patients (2), proper management of side effects is important for a long-term treatment. However, the timeline of side effects has not been systematically studied. Knowing for example when side effects occur and disappear not only allows clinicians to optimize treatment with antipsychotics, but also helps patients monitor and manage their side effects. Therefore, this study aims to systematically assess the occurrence, onset, duration, and severity of side effects associated with antipsychotic treatment.

Specific Aims of the Project: The purpose of this project is to systematically assess temporal trajectories (the occurrence, onset, duration, and severity) of side effects associated with antipsychotic treatment and factors that could influence them.
Primary objective:
Evaluate temporal trajectories of antipsychotic-associated side-effects, e.g., time of onset, duration, temporal changes in severity, and time of disappearance.
Secondly objectives:
Evaluate factors (e.g., type of antipsychotic, dosage) that could influence temporal trajectories of antipsychotic-associated side-effects.

Study Design:

What is the purpose of the analysis being proposed? Please select all that apply.:

Software Used:

Data Source and Inclusion/Exclusion Criteria to be used to define the patient sample for your study: We will consider prospective trials investigating the antipsychotic treatment in monotherapy without further restrictions, such as in terms of randomization, blinding, or follow-up duration. Any antipsychotic drug (ATC codes of N05., except lithium N05AN01) or placebo will be eligible. All participants in eligible studies will be included, irrespective of underlying diagnosis (e.g., schizophrenia, schizoaffective disorder, bipolar disorder, and children with disruptive behavior disorder), stage and severity of illness (e.g., acute, chronic), age (e.g., children, adolescent, and adults), gender, ethnicity, and comorbidities.

Primary and Secondary Outcome Measure(s) and how they will be categorized/defined for your study: We will investigate temporal trajectories of antipsychotic-associated side-effects (e.g., time of onset, duration, changes in their severity, and time of disappearance).
We will consider 1) adverse events, such as extrapyramidal symptoms, akathisia, sedation, weight gain, prolactin elevation, QTc prolongation, and anticholinergic side-effects (e.g., constipation, blurred vision) We will use the Medical Dictionary for Regulatory Activities Terminology (MedDRA)(3) for the classification of adverse events. We will also consider 2) rating scale measures (e.g., Drug Induced Extra Pyramidal Symptoms Scale, Simpson-Angus Extrapyramidal Rating Scale, UKU side effect rating scale, Visual Analog Scale, Barnes Akathisia Rating Scale), and 3) biological measures (e.g., body weight, corrected QT interval on ECG, blood pressure, prolactin, blood glucose)

Main Predictor/Independent Variable and how it will be categorized/defined for your study: The use of antipsychotics will be the independent variable.
The independent variable allows us to investigate the relationship between antipsychotic use and the onset, duration, and severity of the side effects of antipsychotics.

Other Variables of Interest that will be used in your analysis and how they will be categorized/defined for your study: We will consider factors with a potential influence on the temporal trajectories of antipsychotic-associated side-effects, such as specific antipsychotics, dosage of antipsychotics, administration route of antipsychotics, age, gender, ethnicity, diagnosis, life-time antipsychotic exposure (when not available, duration of illness will be used as a proxy in participants with schizophrenia), comorbid disorders, family history, smoking, baseline BMI, measures of psychopathology, and concomitant medications, etc.

Statistical Analysis Plan: First, we will conduct descriptive analysis on time to onset and duration of side effects, and then with statistical models that take temporal trajectories into account, such as the Kaplan-Meier method for binary adverse event data and Mixed-Models-of-Repeated-Measurements (MMRM) for rating-scale outcomes and biological measures. The effect size measures will be the time to onset and the time to resolution for binary adverse events and the change from baseline for rating-scale-outcomes or biological measures.
We consider occurrence and duration of somatic side effects of antipsychotics rather independent of the underlying psychiatric disease (e.g., schizophrenia or bipolar disorder) and therefore, we include a priori studies in different disorders. However, we expect variability in the effects due to differences in participant, intervention, and study characteristics. Therefore, we will explore sources of heterogeneity by subgroup and meta-regression analyses on potentially important effect modifiers such as age, sex, diagnosis (to investigate our assumption above), previous antipsychotic exposure, type, application and dose of antipsychotic, trial duration, RCT (Randomized control trial) and not RCT, ? (see list of ?Other Variables of Interest? above).
Variables which emerge as having a substantial effect on occurrence and duration of side effects will be included in the statistical model by introducing interactions.
We will handle missing outcome and covariate data following Little et al.(4) and impute it, when scientifically sound, by multiple imputations.
Effect size measures and covariates of different studies will be synthesized with meta-analysis.
I-squared and Tau-squared will be used to measure heterogeneity.
To estimate publication bias, we will use funnel plot and Egger?s test. In addition to examining the risk of small-trial/publication bias with funnel plots, we will investigate the potential risk of bias due to selection of reported results within the risk of bias assessment and the potential risk of bias due to selective non-reporting of results with the ROB-MEN(5) tool within the CINeMA assessment.
The standardized Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach will be used to examine the strength of evidence.

Narrative Summary: Antipsychotics are the mainstem for the treatment of schizophrenia and other mental disorder. While use of antipsychotics is essential for favorable outcomes in terms of acute efficacy and relapse prevention, it can cause various unpleasant side effects (1). These side effects are associated with a lower quality of life and poorer adherence in patients (2). It is known that patients acquire tolerance to some side effects in clinical practice whereas others may get more severe over time. However, the temporal trajectories of side effects are yet unclear. Therefore, we will investigate temporal trajectories (e.g., onset, duration) of side effects associated with antipsychotic treatment.

Project Timeline: Start of project: The study will start immediately after the data is available.
The actual state of the project: it is planned to finish data extraction and to start data analysis by 11/2022. The manuscript will be made and submitted in six months (6/2023). The publication is planned for the following six months(12/2023).

Dissemination Plan: The results of this work will be a significant advancement in optimizing antipsychotic treatment for psychiatric disease, which in turn will reduce the burden for patients with schizophrenia and their caregivers, as well as medical costs in the long term. We will make the results available in several publications in scientific journals (e.g., JAMA Psychiatry, Lancet Psychiatry). Moreover, it is expected that the results will be included in local and international treatment guidelines.

Bibliography:

1. Huhn M, Nikolakopoulou A, Schneider-Thoma J, Krause M, Samara M, Peter N, et al. Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis. Lancet. 2019; 394(10202): 939-51.
2. Dibonaventura M, Gabriel S, Dupclay L, Gupta S, Kim E. A patient perspective of the impact of medication side effects on adherence: results of a cross-sectional nationwide survey of patients with schizophrenia. BMC Psychiatry. 2012; 12(1): 20.
3. International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH). Medical Dictionary for Regulatory Activities Terminology (MedDRA). www.meddra.org.
4. Little RJ, D’Agostino R, Cohen ML, Dickersin K, Emerson SS, Farrar JT, et al. The Prevention and Treatment of Missing Data in Clinical Trials. New England Journal of Medicine. 2012; 367(14): 1355-60.
5. Chiocchia V, Nikolakopoulou A, Higgins JPT, Page MJ, Papakonstantinou T, Cipriani A, et al. ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis. BMC Medicine. 2021; 19(1).